CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation

Kinase independent oncogenic cyclin D1

(2015) Mathew C. Casimiro et al.   Aging-US

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

(2015) Concepción Sánchez-Martínez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CDK6 is a regulator of stem cells "Egr" to wake up

(2015) M. L. Guzman   BLOOD

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

(2015) Alba Ruiz et al.   CELL CYCLE

CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells

(2015) Elisa Laurenti et al.   Cell Stem Cell

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers

(2015) Y. Li et al.   Cancer Discovery

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis

(2015) Mathew C. Casimiro et al.   Oncotarget

Cyclin D1 Induces Chromosomal Instability

(2015)   Oncotarget

Unexpected Outcomes of CDK4/6 Inhibition

(2015) Yoon Jong Choi et al.   Oncotarget

CDK6 and p16INK4a in lymphoid malignancies

(2015) Karoline Kollmann et al.   Oncotarget

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

(2014) T. Placke et al.   BLOOD

CDK6, a new target in MLL-driven leukemia

(2014) I. Antony-Debre et al.   BLOOD

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis

(2014) E. Rodriguez-Diez et al.   BLOOD

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

(2014) Ruth Scheicher et al.   BLOOD

MLL fusion-driven activation ofCDK6potentiates proliferation inMLL-rearranged infant ALL

(2014) Marieke Van der Linden et al.   CELL CYCLE

Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells

(2014) Eduardo Pauls et al.   JOURNAL OF IMMUNOLOGY

Genetic Characterization of the Role of the Cip/Kip Family of Proteins as Cyclin-Dependent Kinase Inhibitors and Assembly Factors

(2014) A. Cerqueira et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression

(2014) Katja Handschick et al.   MOLECULAR CELL

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

(2014) Yoonjin Lee et al.   NATURE

New Roles of Cyclin D1

(2013) Richard G. Pestell   AMERICAN JOURNAL OF PATHOLOGY

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

(2013) Karoline Kollmann et al.   CANCER CELL

CDK6 binds and promotes the degradation of the EYA2 protein

(2013) Dawn Kohrt et al.   CELL CYCLE

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly

(2013) Muhammad S. Hussain et al.   HUMAN MOLECULAR GENETICS

Multiple Mechanisms for E2F Binding Inhibition by Phosphorylation of the Retinoblastoma Protein C-Terminal Domain

(2013) Jason R. Burke et al.   JOURNAL OF MOLECULAR BIOLOGY

The Stat3 paradox: A killer and an oncogene

(2013) Henrike K. Resemann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Signaling through cyclin D-dependent kinases

(2013) Y J Choi et al.   ONCOGENE

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

(2013) Hisham Mohammed et al.   Cell Reports

Cell-Cycle Control of Developmentally Regulated Transcription Factors Accounts for Heterogeneity in Human Pluripotent Cells

(2013) Amar M. Singh et al.   Stem Cell Reports

Cyclin D1 is a NF-κB corepressor

(2012) María F. Rubio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

(2012) Catherine M. Sawai et al.   CANCER CELL

Proteomic Identification of a Direct Role for Cyclin D1 in DNA Damage Repair

(2012) S. Jirawatnotai et al.   CANCER RESEARCH

Regulation of transcription and chromatin structure by pRB: Here, there and everywhere

(2012) Srikanth Talluri et al.   CELL CYCLE

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Modification of the DNA Damage Response by Therapeutic CDK4/6 Inhibition

(2012) Jeffry L. Dean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

(2012) Mathew C. Casimiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

(2012) Roland Schmitz et al.   NATURE

Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression

(2012) Holger Buss et al.   PLoS One

CDK6 kinase activity is required for thymocyte development

(2011) M. G. Hu et al.   BLOOD

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

The meaning of p16ink4aexpression in tumors

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer

(2011) Gottfried E. Konecny et al.   CLINICAL CANCER RESEARCH

Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway

(2011) K. Nakajima et al.   DEVELOPMENT

Opposing roles of NF- B in anti-cancer treatment outcome unveiled by cross-species investigations

(2011) H. Jing et al.   GENES & DEVELOPMENT

RB Restricts DNA Damage-Initiated Tumorigenesis through an LXCXE-Dependent Mechanism of Transcriptional Control

(2011) Ryan J. Bourgo et al.   MOLECULAR CELL

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

CDK-Mediated Regulation of Cell Functions via c-Jun Phosphorylation and AP-1 Activation

(2011) Tony J. Vanden Bush et al.   PLoS One

Conserved RB functions in development and tumor suppression

(2011) Gabriel M. Gordon et al.   Protein & Cell

Moonlighting proteins: An intriguing mode of multitasking

(2010) Daphne H.E.W. Huberts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

(2010) Marta Puyol et al.   CANCER CELL

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response

(2010) Z. Li et al.   CANCER RESEARCH

Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding

(2010) Jason R. Burke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

(2010) Frédéric Bienvenu et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

(2010) J L Dean et al.   ONCOGENE

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

(2010) W. R. Wiedemeyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinicopathologic Features of CDK6 Translocation-associated B-cell Lymphoproliferative Disorders

(2009) Dong Chen et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis

(2009) M. G. Hu et al.   CANCER RESEARCH

The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor

(2009) Andrea Ecker   Frontiers in Bioscience-Landmark

PU.1 Directly Regulatescdk6Gene Expression, Linking the Cell Proliferation and Differentiation Programs in Erythroid Cells

(2009) Kevin S. Choe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

The Transcription Factor EGR1 Controls Both the Proliferation and Localization of Hematopoietic Stem Cells

(2008) Irene M. Min et al.   Cell Stem Cell

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE