The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cells

GP96 is a GARP chaperone and controls regulatory T cell functions

(2015) Yongliang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors

(2014) Paul T. Thevenot et al.   IMMUNITY

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis

(2014) Thomas Condamine et al.   JOURNAL OF CLINICAL INVESTIGATION

KDEL-Retained Antigen in B Lymphocytes Induces a Proinflammatory Response: A Possible Role for Endoplasmic Reticulum Stress in Adaptive T Cell Immunity

(2014) M. C. Wheeler et al.   JOURNAL OF IMMUNOLOGY

PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation

(2014) G. P. Meares et al.   MOLECULAR AND CELLULAR BIOLOGY

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

(2014) Allison S. Cleary et al.   NATURE

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

(2014) Andriy Marusyk et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

(2014) Fabiola Osorio et al.   NATURE IMMUNOLOGY

Correction: A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow

(2014) João Pedro Pereira et al.   PLoS One

X Box-Binding Protein 1 Regulates Angiogenesis in Human Pancreatic Adenocarcinomas

(2014) Lorenzo Romero-Ramirez et al.   Translational Oncology

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

(2014) Arvin B. Tam et al.   Cell Reports

Trial Watch

(2014) Erika Vacchelli et al.   OncoImmunology

The fat side of prostate cancer

(2013) Giorgia Zadra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Immune Chaperone gp96 Drives the Contributions of Macrophages to Inflammatory Colon Tumorigenesis

(2013) Crystal Morales et al.   CANCER RESEARCH

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Gene Copy-Number Alterations: A Cost-Benefit Analysis

(2013) Yun-Chi Tang et al.   CELL

Immunosurveillance against tetraploidization-induced colon tumorigenesis

(2013) Alice Boilève et al.   CELL CYCLE

Genome evolution during progression to breast cancer

(2013) D. E. Newburger et al.   GENOME RESEARCH

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

Molecular Classification of Prostate Cancer Progression: Foundation for Marker-Driven Treatment of Prostate Cancer

(2013) C. J. Logothetis et al.   Cancer Discovery

A Janus-faced role of the unfolded protein response in antitumor immunity

(2013) Navin R. Mahadevan et al.   OncoImmunology

New Insights into the Troubles of Aneuploidy

(2012) Jake J. Siegel et al.   Annual Review of Cell and Developmental Biology

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation

(2012) Jingru Sun et al.   EMBO REPORTS

Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation

(2012) Jisu Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-211 Is a Prosurvival MicroRNA that Regulates chop Expression in a PERK-Dependent Manner

(2012) Nilesh S. Chitnis et al.   MOLECULAR CELL

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming

(2012) Navin R. Mahadevan et al.   PLoS One

ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK

(2012) Arvin B. Tam et al.   PLoS One

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

Colon tumour cells increase PGE2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation

(2011) H. R. Roberts et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

CD44+/CD24−/low cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome

(2011) Michael O. Idowu et al.   HUMAN PATHOLOGY

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

(2011) Rafal Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Stress Inside Out: Cell-Extrinsic Effects of the Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment

(2011) N. R. Mahadevan et al.   JOURNAL OF IMMUNOLOGY

A non-genetic route to aneuploidy in human cancers

(2011) Matej Krajcovic et al.   NATURE CELL BIOLOGY

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

(2011) N. R. Mahadevan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Inositol-requiring enzyme 1  is a key regulator of angiogenesis and invasion in malignant glioma

(2010) G. Auf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRP94 in ER quality control and stress responses

(2010) Davide Eletto et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

(2009) Monica L. DeLay et al.   ARTHRITIS AND RHEUMATISM

HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

(2009) Li Chen et al.   BIOCHEMICAL PHARMACOLOGY

ER stress affects processing of MHC class I-associated peptides

(2009) Diana P Granados et al.   BMC IMMUNOLOGY

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism

(2009) L. A. Norian et al.   CANCER RESEARCH

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Presentation of Telomerase Reverse Transcriptase, a Self-Tumor Antigen, is Down-regulated by Histone Deacetylase Inhibition

(2008) I. Pellicciotta et al.   CANCER RESEARCH

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Aneuploidy: Cells Losing Their Balance

(2008) Eduardo M. Torres et al.   GENETICS

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Cytokine-based transformation of immune surveillance into tumor-promoting inflammation

(2008) J B Mumm et al.   ONCOGENE

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

(2008) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE