Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

Acute myeloid leukemia with myelodysplasia-related changes are characterized by a specific molecular pattern with high frequency of ASXL1 mutations

(2012) Raynier Devillier et al.   AMERICAN JOURNAL OF HEMATOLOGY

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

(2012) S. Tanaka et al.   BLOOD

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

(2012) Omar Abdel-Wahab et al.   CANCER CELL

Epigenetic alterations in hematopoietic malignancies

(2012) Young Rock Chung et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Mutations in epigenetic regulators in myelodysplastic syndromes

(2012) Gorica Nikoloski et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

(2012) Véronique Gelsi-Boyer et al.   Journal of Hematology & Oncology

ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome

(2012) S Schnittger et al.   LEUKEMIA

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms

(2012) S. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A

(2012) A. A. Chaudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

New mutations and pathogenesis of myeloproliferative neoplasms

(2011) W. Vainchenker et al.   BLOOD

Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells

(2011) A. Gerrits et al.   BLOOD

Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

(2011) Qi Cao et al.   CANCER CELL

Clinical Implications of Novel Mutations in Epigenetic Modifiers in AML

(2011) Omar Abdel-Wahab et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Prognostic Significance of ASXL1 Mutations in Patients With Myelodysplastic Syndromes

(2011) Felicitas Thol et al.   JOURNAL OF CLINICAL ONCOLOGY

Eμ/miR-125b transgenic mice develop lethal B-cell malignancies

(2011) Y Enomoto et al.   LEUKEMIA

Deregulation of microRNAs in myelodysplastic syndrome

(2011) G W Rhyasen et al.   LEUKEMIA

Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms

(2011) O Abdel-Wahab et al.   LEUKEMIA

Update on cytogenetic and molecular changes in myelodysplastic syndromes

(2011) Brigitte Schlegelberger et al.   LEUKEMIA & LYMPHOMA

Two types of C/EBP  mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models

(2010) N. Kato et al.   BLOOD

Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias

(2010) Julien Rocquain et al.   BMC CANCER

ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia

(2010) Véronique Gelsi-Boyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia

(2010) Elisa Tassano et al.   GENES CHROMOSOMES & CANCER

Characterization of Leukocyte Mono-immunoglobulin-like Receptor 7 (LMIR7)/CLM-3 as an Activating Receptor

(2010) Yutaka Enomoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Additional Sex Comb-like (ASXL) Proteins 1 and 2 Play Opposite Roles in Adipogenesis via Reciprocal Regulation of Peroxisome Proliferator-activated Receptor γ

(2010) Ui-Hyun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia

(2010) E Chapiro et al.   LEUKEMIA

The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration

(2010) O Abdel-Wahab et al.   LEUKEMIA

Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia

(2010) J Boultwood et al.   LEUKEMIA

CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation

(2010) Jasmin Batliner et al.   MOLECULAR IMMUNOLOGY

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation

(2010) Ryu-Suke Nozawa et al.   NATURE CELL BIOLOGY

MicroRNA miR-125b causes leukemia

(2010) M. Bousquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets

(2010) A. G. L. Ooi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations of polycomb-associated geneASXL1in myelodysplastic syndromes and chronic myelomonocytic leukaemia

(2009) Véronique Gelsi-Boyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice

(2009) C.L. Fisher et al.   DEVELOPMENTAL BIOLOGY

AML1 mutations induced MDS and MDS/AML in a mouse BMT model

(2008) N. Watanabe-Okochi et al.   BLOOD

The Organization of Histone H3 Modifications as Revealed by a Panel of Specific Monoclonal Antibodies

(2008) Hiroshi Kimura et al.   CELL STRUCTURE AND FUNCTION

Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

(2008) Marina Bousquet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression and functional role of MDL-1 (CLEC5A) in mouse myeloid lineage cells

(2008) Naoko Aoki et al.   JOURNAL OF LEUKOCYTE BIOLOGY