The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   Annual Review of Biochemistry

HER2 expression status in diverse cancers: review of results from 37,992 patients

(2015) Min Yan et al.   CANCER AND METASTASIS REVIEWS

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

How Does Multistep Tumorigenesis Really Proceed?

(2015) Christine L. Chaffer et al.   Cancer Discovery

The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases

(2015) Vinochani Pillay et al.   NEOPLASIA

Liver Stem Cells, Where Art Thou?

(2014) Markus Grompe   Cell Stem Cell

Replication stress and cancer: It takes two to tango

(2014) Emilio Lecona et al.   EXPERIMENTAL CELL RESEARCH

DNA replication stress: Causes, resolution and disease

(2014) Abdelghani Mazouzi et al.   EXPERIMENTAL CELL RESEARCH

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Emerging interactions between skin stem cells and their niches

(2014) Ya-Chieh Hsu et al.   NATURE MEDICINE

SnapShot: Adult Neurogenesis in the V-SVZ

(2014) Cheuk Ka Tong et al.   NEURON

Amphiregulin

(2014) Carmen Berasain et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The magnificent seven: Epidermal growth factor receptor ligands

(2014) Marlon R. Schneider   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cycling progenitors maintain epithelia while diverse cell types contribute to repair

(2013) David P. Doupé et al.   BIOESSAYS

Trastuzumab for patients with HER2 positive breast cancer: Delivery, duration and combination therapies

(2013) Ana Catarina Pinto et al.   BREAST

Oncogenic ERBB3 Mutations in Human Cancers

(2013) Bijay S. Jaiswal et al.   CANCER CELL

SnapShot: The Intestinal Crypt

(2013) Hans Clevers et al.   CELL

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling

(2013) M. Kitade et al.   GENES & DEVELOPMENT

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

(2013) Phuong L Doan et al.   NATURE MEDICINE

Epidermal Growth Factor Receptor as a Therapeutic Target in Glioblastoma

(2013) B. Kalman et al.   NEUROMOLECULAR MEDICINE

Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer

(2013) N Panupinthu et al.   ONCOGENE

Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice

(2013) Giovanna Ponti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain

(2013) Alma Y. Galvez-Contreras et al.   Frontiers in Cellular Neuroscience

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

HER2/neuGene Amplification and Protein Overexpression in Gastric and Gastroesophageal Junction Adenocarcinoma: A Review of Histopathology, Diagnostic Testing, and Clinical Implications

(2012) Jaclyn F. Hechtman et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Adult Neural Stem Cells Bridge Their Niche

(2012) Luis C. Fuentealba et al.   Cell Stem Cell

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis

(2012) M. V. Gomez-Gaviro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor

(2011) Oscar Gonzalez-Perez et al.   BRAIN RESEARCH REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and osterix

(2011) Ji Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal Growth Factor Receptor Expression Identifies Functionally and Molecularly Distinct Tumor-Initiating Cells in Human Glioblastoma Multiforme and Is Required for Gliomagenesis

(2010) S. Mazzoleni et al.   CANCER RESEARCH

Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1α

(2010) Damian C. Genetos et al.   CELL AND TISSUE RESEARCH

Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe

(2010) T. Yasugi et al.   DEVELOPMENT

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

(2010) Lai Kuan Goh et al.   JOURNAL OF CELL BIOLOGY

The Constitutive Activity of Epidermal Growth Factor Receptor vIII Leads to Activation and Differential Trafficking of Wild-type Epidermal Growth Factor Receptor and erbB2

(2010) Reema Zeineldin et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury

(2010) David Hsu et al.   LABORATORY INVESTIGATION

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

(2010) Adan Aguirre et al.   NATURE

Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells

(2010) L Sauer et al.   ONCOGENE

EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism

(2010) G Pines et al.   ONCOGENE

Roles for Growth Factors in Cancer Progression

(2010) Esther Witsch et al.   PHYSIOLOGY

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Detection of EGFR Copy Number Changes and EGFR Variant III: Technical Aspects and Relevance for Glioma Diagnostics

(2009) Judith Jeuken et al.   BRAIN PATHOLOGY

Tumor-Initiating Cells of HER2-Positive Carcinoma Cell Lines Express the Highest Oncoprotein Levels and Are Sensitive to Trastuzumab

(2009) A. Magnifico et al.   CLINICAL CANCER RESEARCH

The Hair Follicle as a Dynamic Miniorgan

(2009) Marlon R. Schneider et al.   CURRENT BIOLOGY

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

(2009) Todd D Prickett et al.   NATURE GENETICS

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti-HER-2 Therapy and Personalized Medicine

(2009) J. S. Ross et al.   ONCOLOGIST

MutatedERBB4: a novel drug target in metastatic melanoma?

(2009) Kari Kurppa et al.   Pigment Cell & Melanoma Research

Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny

(2009) E. Pastrana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic EGFR Signaling Networks in Glioma

(2009) P. H. Huang et al.   Science Signaling

Beyond Wavy Hairs

(2008) Marlon R. Schneider et al.   AMERICAN JOURNAL OF PATHOLOGY

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

The Color-Vision Circuit in the Medulla of Drosophila

(2008) Javier Morante et al.   CURRENT BIOLOGY

Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity inApc+/Minmice

(2008) Maik Dahlhoff et al.   FEBS LETTERS

Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells

(2008) Akio Soeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion

(2008) H Korkaya et al.   ONCOGENE

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems Biology of Growth Factor-Induced Receptor Endocytosis

(2008) Yaara Zwang et al.   TRAFFIC