Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Direct Autocrine Action of Insulin on  -Cells: Does It Make Physiological Sense?

(2013) C. J. Rhodes et al.   DIABETES

Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38  MAPK During Insulin Resistance

(2013) Y. Qi et al.   DIABETES

Hepatic ERK activity plays a role in energy metabolism

(2013) Ping Jiao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

(2013) Tadahiro Kitamura   Nature Reviews Endocrinology

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

(2013) T. Galbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

(2013) T. Shay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxO6 in glucose metabolism (FoxO6在葡萄糖代谢中的作用)

(2013) Dae Hyun Kim et al.   Journal of Diabetes

Inflammation during obesity is not all bad: evidence from animal and human studies

(2012) Jianping Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease

(2012) Christian Rask-Madsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets

(2012) Giulio R. Romeo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

(2012) Hongxia Ren et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

(2012) Deborah M. Muoio et al.   Cell Metabolism

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action

(2012) Marianna Sadagurski et al.   Cell Metabolism

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis

(2012) Kyoichiro Tsuchiya et al.   Cell Metabolism

RTEF-1 Attenuates Blood Glucose Levels by Regulating Insulin-Like Growth Factor Binding Protein-1 in the Endothelium

(2012) Angela F. Messmer-Blust et al.   CIRCULATION RESEARCH

FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development

(2012) Arunima Sengupta et al.   DEVELOPMENTAL DYNAMICS

Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity

(2012) R. V. Cohen et al.   DIABETES CARE

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

The Foxo Family: Partners in Crime or Silent Heroes

(2012) Jennifer L. Estall   ENDOCRINOLOGY

NF-κB Essential Modifier Is Required for Hepatocyte Proliferation and the Oval Cell Reaction After Partial Hepatectomy in Mice

(2012) Yann Malato et al.   GASTROENTEROLOGY

Bariatric Surgery and Long-term Cardiovascular Events

(2012) Lars Sjöström et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Liver-specific p70 S6 Kinase Depletion Protects against Hepatic Steatosis and Systemic Insulin Resistance

(2012) Eun Ju Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

Bariatric surgery for type 2 diabetes

(2012) John B Dixon et al.   LANCET

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

(2012) Mingjian Lu et al.   NATURE MEDICINE

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Regulation of Metabolism: A Cross Talk Between Gut Microbiota and Its Human Host

(2012) Rémy Burcelin   PHYSIOLOGY

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

(2011) Ryan G. Holzer et al.   CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

RETRACTED: Impairment of Central Leptin-Mediated PI3K Signaling Manifested as Hepatic Steatosis Independent of Hyperphagia and Obesity

(2011) James P. Warne et al.   Cell Metabolism

Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice

(2011) Alexander S. Banks et al.   Cell Metabolism

Asymmetric Arginine Dimethylation Determines Life Span in C. elegans by Regulating Forkhead Transcription Factor DAF-16

(2011) Yuta Takahashi et al.   Cell Metabolism

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver

(2011) Dae Hyun Kim et al.   DIABETES

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030

(2011) David R. Whiting et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice

(2011) Kebin Zhang et al.   ENDOCRINOLOGY

Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes

(2011) Hua V. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

(2011) Olivier Bezy et al.   JOURNAL OF CLINICAL INVESTIGATION

IDF's view of bariatric surgery in type 2 diabetes

(2011) Paul Zimmet et al.   LANCET

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism

(2011) Arlee Fafalios et al.   NATURE MEDICINE

Myocardial AKT: The Omnipresent Nexus

(2011) Mark A. Sussman et al.   PHYSIOLOGICAL REVIEWS

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

(2011) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

Excess exposure to insulin may be the primary cause of insulin resistance

(2010) Wenhong Cao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic Surgery to Treat Type 2 Diabetes: Clinical Outcomes and Mechanisms of Action

(2010) Francesco Rubino et al.   Annual Review of Medicine

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity

(2010) Kyle L. Hoehn et al.   Cell Metabolism

Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice

(2010) Christian Rask-Madsen et al.   Cell Metabolism

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity

(2010) J. Jager et al.   DIABETOLOGIA

FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress

(2010) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice

(2010) Zhidan Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways

(2010) Y. C. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin enhances glucose-stimulated insulin secretion in healthy humans

(2010) C. Bouche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

(2009) Christian Pehmøller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction

(2009) Jian Xu et al.   CIRCULATION

Human IL6 enhances leptin action in mice

(2009) M. Sadagurski et al.   DIABETOLOGIA

The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation

(2009) R. K. Simmons et al.   DIABETOLOGIA

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

(2009) Zengqiang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO Transcription Factors Promote Autophagy in Cardiomyocytes

(2009) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Is a Stronger Inducer of Insulin Resistance than Hyperglycemia in Mice with Type 1 Diabetes Mellitus (T1DM)

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Troponin Regulatory Function and Dynamics Revealed by H/D Exchange-Mass Spectrometry

(2009) Devanand Kowlessur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

(2009) Marie-Therese Rached et al.   JOURNAL OF CLINICAL INVESTIGATION

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

(2009) S. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes

(2008) Safina Ali et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

O-GlcNAc modification of FoxO1 increases its transcriptional activity: A role in the glucotoxicity phenomenon?

(2008) MeiShiue Kuo et al.   BIOCHIMIE

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

The Emerging Genetic Architecture of Type 2 Diabetes

(2008) Alessandro Doria et al.   Cell Metabolism

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

(2008) Naoto Kubota et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Regulation of Cardiomyocyte Proliferation and Myocardial Growth During Development by FOXO Transcription Factors

(2008) Heather J. Evans-Anderson et al.   CIRCULATION RESEARCH

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

(2008) E. R. Duncan et al.   DIABETES

The Metabolic Syndrome

(2008) Marc-Andre Cornier et al.   ENDOCRINE REVIEWS

An Integrated View of Insulin Resistance and Endothelial Dysfunction

(2008) Ranganath Muniyappa et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

O-GlcNAc Regulates FoxO Activation in Response to Glucose

(2008) Michael P. Housley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP2A Regulates the Pro-apoptotic Activity of FOXO1

(2008) Ling Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle

(2008) Eric B. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

Activation of p38 mitogen-activated protein kinase abolishes insulin-mediated myocardial protection against ischemia-reperfusion injury

(2007) Weidong Chai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM