The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities

Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations

(2014) Leanne de Kock et al.   ACTA NEUROPATHOLOGICA

Biallelic DICER1 Mutations in Sporadic Pleuropulmonary Blastoma

(2014) M. Seki et al.   CANCER RESEARCH

A Variety of Dicer Substrates in Human and C. elegans

(2014) Agnieszka Rybak-Wolf et al.   CELL

A Requirement for ERK-Dependent Dicer Phosphorylation in Coordinating Oocyte-to-Embryo Transition in C. elegans

(2014) Melanie Drake et al.   DEVELOPMENTAL CELL

A MicroRNA Processing Defect in Smokers' Macrophages Is Linked to SUMOylation of the Endonuclease DICER

(2014) Thomas J. Gross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline and SomaticDICER1Mutations in a Pituitary Blastoma Causing Infantile-Onset Cushing's Disease

(2014) Taninee Sahakitrungruang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exploring the Association BetweenDICER1Mutations and Differentiated Thyroid Carcinoma

(2014) Leanne de Kock et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain ofDICER1cause GLOW syndrome

(2014) Steven Klein et al.   JOURNAL OF MEDICAL GENETICS

A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

(2014) Yuan Tian et al.   MOLECULAR CELL

An HIV-Encoded Antisense Long Noncoding RNA Epigenetically Regulates Viral Transcription

(2014) Sheena Saayman et al.   MOLECULAR THERAPY

Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA

(2014) Eleanor White et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors

(2014) Alexandre Desjardins et al.   NUCLEIC ACIDS RESEARCH

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

(2014) Dinesh Rakheja et al.   Nature Communications

Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain

(2014) Zhongmin Liu et al.   Protein & Cell

The MicroRNA Biology of the Mammalian Nucleus

(2014) Thomas C Roberts   Molecular Therapy-Nucleic Acids

Serum levels of mature microRNAs in DICER1-mutated pleuropulmonary blastoma

(2014) M J Murray et al.   Oncogenesis

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

(2013) Hiromitsu Ota et al.   CELL

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

(2013) Steven G. Chaulk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guided by RNAs: X-Inactivation as a Model for lncRNA Function

(2013) John E. Froberg et al.   JOURNAL OF MOLECULAR BIOLOGY

BiallelicDICER1mutations occur in Wilms tumours

(2013) MK Wu et al.   JOURNAL OF PATHOLOGY

Substrate-specific structural rearrangements of human Dicer

(2013) David W Taylor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

Germ-line and somaticDICER1mutations in a pleuropulmonary blastoma

(2013) Leanne de Kock et al.   PEDIATRIC BLOOD & CANCER

DICER1mutations in an adolescent with cervical embryonal rhabdomyosarcoma (cERMS)

(2013) Eva Tomiak et al.   PEDIATRIC BLOOD & CANCER

Identification of stable, high copy number, medium-sized RNA degradation intermediates that accumulate in plants under non-stress conditions

(2013) Martyna Nowacka et al.   PLANT MOLECULAR BIOLOGY

Distinguishable In Vitro Binding Mode of Monomeric TRBP and Dimeric PACT with siRNA

(2013) Tomoko Takahashi et al.   PLoS One

A New Short Oligonucleotide-Based Strategy for the Precursor-Specific Regulation of microRNA Processing by Dicer

(2013) Anna Kurzynska-Kokorniak et al.   PLoS One

miR-192 Directly Binds and Regulates Dicer1 Expression in Neuroblastoma

(2013) Galina Feinberg-Gorenshtein et al.   PLoS One

RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators

(2013) A. D. Redfern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection

(2013) Laurieann Casey Klockow et al.   VIROLOGY

Loss and Retention of RNA Interference in Fungi and Parasites

(2013) Francisco E. Nicolás et al.   PLoS Pathogens

The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo

(2012) Shuo Gu et al.   CELL

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

(2012) Ryuya Fukunaga et al.   CELL

A Role for Small RNAs in DNA Double-Strand Break Repair

(2012) Wei Wei et al.   CELL

Coordinated Activities of Human Dicer Domains in Regulatory RNA Processing

(2012) Enbo Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

Cancer-associated somaticDICER1hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage

(2012) MS Anglesio et al.   JOURNAL OF PATHOLOGY

Human- and Virus-Encoded microRNAs as Potential Targets of Antiviral Therapy

(2012) Anna Kurzynska-Kokorniak et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Evolution of Animal and Plant Dicers: Early Parallel Duplications and Recurrent Adaptation of Antiviral RNA Binding in Plants

(2012) Krishanu Mukherjee et al.   MOLECULAR BIOLOGY AND EVOLUTION

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells

(2012) Monika Gullerova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis

(2012) Giuseppe Nicastro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Argonaute proteins couple chromatin silencing to alternative splicing

(2012) Maya Ameyar-Zazoua et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular architecture of human Dicer

(2012) Pick-Wei Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of human Dicer by the resident ER membrane protein CLIMP-63

(2012) Geneviève Pépin et al.   NUCLEIC ACIDS RESEARCH

A small RNA response at DNA ends in Drosophila

(2012) Katharina M. Michalik et al.   NUCLEIC ACIDS RESEARCH

Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion

(2012) S M Jafarnejad et al.   ONCOGENE

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

(2012) Y. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRBP alters human precursor microRNA processing in vitro

(2012) H. Y. Lee et al.   RNA

In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs

(2012) A. M. Gurtan et al.   RNA

A Distinct Expression Pattern of the Long 3′-Untranslated Region Dicer mRNA and Its Implications for Posttranscriptional Regulation in Colorectal Cancer

(2012) Yasushi Hamaya et al.   Clinical and Translational Gastroenterology

Modulation of microRNA Activity by Semi-microRNAs

(2012) Isabelle Plante et al.   Frontiers in Genetics

PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis

(2011) P Briata et al.   CELL DEATH AND DIFFERENTIATION

The role of the precursor structure in the biogenesis of microRNA

(2011) Julia Starega-Roslan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms Involved in the Development of Chronic Hepatitis C as Potential Targets of Antiviral Therapy

(2011) Paulina Jackowiak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome

(2011) I. Slade et al.   JOURNAL OF MEDICAL GENETICS

RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS

(2011) Shangxi Xiao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

(2011) Hiroshi I. Suzuki et al.   MOLECULAR CELL

siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes

(2011) Cameron L. Noland et al.   MOLECULAR CELL

The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response

(2011) Xinna Zhang et al.   MOLECULAR CELL

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

(2011) James R Tollervey et al.   NATURE NEUROSCIENCE

Recognition of the pre-miRNA structure by Drosophila Dicer-1

(2011) Akihisa Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels

(2011) Yamina Bennasser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

(2011) Alireza Heravi-Moussavi et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA degradome--its biogenesis and functions

(2011) P. Jackowiak et al.   NUCLEIC ACIDS RESEARCH

The Role of Dicer Protein Partners in the Processing of MicroRNA Precursors

(2011) Edyta Koscianska et al.   PLoS One

Deep sequencing of microRNA precursors reveals extensive 3' end modification

(2011) M. A. Newman et al.   RNA

Compatibility with Killer Explains the Rise of RNAi-Deficient Fungi

(2011) I. A. Drinnenberg et al.   SCIENCE

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Selection of RNA Oligonucleotides That Can Modulate Human Dicer Activity In Vitro

(2011) Agata Tyczewska et al.   Nucleic Acid Therapeutics

Oncogenic microRNAs (OncomiRs) as a new class of cancer biomarkers

(2010) Vladimir A. Krutovskikh et al.   BIOESSAYS

Complexity in the regulation of Dicer expression: Dicer variant proteins are differentially expressed in epithelial and mesenchymal breast cancer cells and decreased during EMT

(2010) G W Hinkal et al.   BRITISH JOURNAL OF CANCER

The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network

(2010) Lakshmanane Boominathan   CANCER AND METASTASIS REVIEWS

Lineage-Specific Transcriptional Regulation of DICER by MITF in Melanocytes

(2010) Carmit Levy et al.   CELL

Lin28: A MicroRNA Regulator with a Macro Role

(2010) Srinivas R. Viswanathan et al.   CELL

A MicroRNA Targeting Dicer for Metastasis Control

(2010) Graziano Martello et al.   CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

A novel splice variant of the human dicer gene is expressed in neuroblastoma cells

(2010) Nicoletta Potenza et al.   FEBS LETTERS

Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome

(2010) T. R. Mercer et al.   GENOME RESEARCH

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes

(2010) Chantelle F. Sephton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-Specific Kinetics of Dicer-Catalyzed RNA Processing

(2010) Srinivas Chakravarthy et al.   JOURNAL OF MOLECULAR BIOLOGY

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

(2010) Gracjan Michlewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dicer Is Associated with Ribosomal DNA Chromatin in Mammalian Cells

(2010) Lasse Sinkkonen et al.   PLoS One

Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease

(2010) A. Nakagawa et al.   SCIENCE

Characterization of the TRBP domain required for Dicer interaction and function in RNA interference

(2009) Sylvanne M Daniels et al.   BMC MOLECULAR BIOLOGY

Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype

(2009) G Grelier et al.   BRITISH JOURNAL OF CANCER

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

(2009) Zain Paroo et al.   CELL

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1

(2009) M M Ghodgaonkar et al.   CELL DEATH AND DIFFERENTIATION

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

(2009) I Lambertz et al.   CELL DEATH AND DIFFERENTIATION

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages

(2009) Tina Ruggiero et al.   FASEB JOURNAL

Dicer1 functions as a haploinsufficient tumor suppressor

(2009) M. S. Kumar et al.   GENES & DEVELOPMENT

The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine

(2009) Ashley J. Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dicer is regulated by cellular stresses and interferons

(2009) Jennifer L. Wiesen et al.   MOLECULAR IMMUNOLOGY

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

Control of alternative splicing through siRNA-mediated transcriptional gene silencing

(2009) Mariano Alló et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into RNA processing by the human RISC-loading complex

(2009) Hong-Wei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sequence-non-specific effects of RNA interference triggers and microRNA regulators

(2009) Marta Olejniczak et al.   NUCLEIC ACIDS RESEARCH

Structure of the Human Dicer-TRBP Complex by Electron Microscopy

(2009) Pick-Wei Lau et al.   STRUCTURE

Alterations of the microRNA network cause neurodegenerative disease

(2009) Sébastien S. Hébert et al.   TRENDS IN NEUROSCIENCES

Stimuli-dependent cleavage of Dicer during apoptosis

(2008) Alexey A. Matskevich et al.   BIOCHEMICAL JOURNAL

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain

(2008) Vildan Dincbas-Renqvist et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer

(2008) S. Ambs et al.   CANCER RESEARCH

Inhibition of Dicing of Guanosine-Rich shRNAs by Quadruplex-Binding Compounds

(2008) Anja Henn et al.   CHEMBIOCHEM

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibition of Human Dicer by Its Internal Helicase Domain

(2008) Enbo Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

An endogenous small interfering RNA pathway in Drosophila

(2008) Benjamin Czech et al.   NATURE

Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes

(2008) Masayo Kagami et al.   NATURE GENETICS

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells

(2008) Thomas Ohrt et al.   NUCLEIC ACIDS RESEARCH

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

(2008) J. J. Forman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro reconstitution of the human RISC-loading complex

(2008) I. J. MacRae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE

HCV core protein interacts with Dicer to antagonize RNA silencing

(2008) Weixian Chen et al.   VIRUS RESEARCH

MicroRNAs, the immune system and rheumatic disease

(2008) Esmerina Tili et al.   Nature clinical practice. Rheumatology