Structure-based redesign of proteins for minimal T-cell epitope content

Drug development: longer-lived proteins

(2012) Stephan Kontos et al.   CHEMICAL SOCIETY REVIEWS

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

(2012) Timothy A Whitehead et al.   NATURE BIOTECHNOLOGY

Further progress on defining highly conserved immunogenic epitopes for a global HIV vaccine: HLA-A3-restricted GAIA vaccine epitopes

(2012) Anne S. De Groot et al.   Human Vaccines & Immunotherapeutics

Toward more accurate pan-specific MHC-peptide binding prediction: a review of current methods and tools

(2011) L. Zhang et al.   BRIEFINGS IN BIOINFORMATICS

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo

(2011) Leonard Moise et al.   CLINICAL IMMUNOLOGY

Computational Design of the Sequence and Structure of a Protein-Binding Peptide

(2011) Deanne W. Sammond et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

What's fueling the biotech engine—2010 to 2011

(2011) Saurabh Aggarwal   NATURE BIOTECHNOLOGY

Beyond natural antibodies: the power of in vitro display technologies

(2011) Andrew R M Bradbury et al.   NATURE BIOTECHNOLOGY

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

(2011) Sarel J. Fleishman et al.   PLoS One

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

(2011) Po-Ssu Huang et al.   PLoS One

Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

(2011) J. R. Cantor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments

(2011) Lu He et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

OPTIMIZATION OF THERAPEUTIC PROTEINS TO DELETE T-CELL EPITOPES WHILE MAINTAINING BENEFICIAL RESIDUE INTERACTIONS

(2011) ANDREW S. PARKER et al.   Journal of Bioinformatics and Computational Biology

How significant is a protein structure similarity with TM-score = 0.5?

(2010) Jinrui Xu et al.   BIOINFORMATICS

Optimization algorithms for functional deimmunization of therapeutic proteins

(2010) Andrew S Parker et al.   BMC BIOINFORMATICS

Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design

(2010) Bruno E. Correia et al.   JOURNAL OF MOLECULAR BIOLOGY

Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics

(2009) Anne S. De Groot et al.   CLINICAL IMMUNOLOGY

Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma

(2009) Min Guo et al.   NATURE

In silico-accelerated identification of conserved and immunogenic variola/vaccinia T-cell epitopes

(2009) Leonard Moise et al.   VACCINE

The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies

(2008) A. L. Cuff et al.   NUCLEIC ACIDS RESEARCH

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

(2008) R. Ujwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach

(2008) Peng Wang et al.   PLoS Computational Biology