Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome

Interferon Lambda Alleles Predict Innate Antiviral Immune Responses and Hepatitis C Virus Permissiveness

(2014) Timothy Sheahan et al.   Cell Host & Microbe

Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes

(2014) Masao Honda et al.   HEPATOLOGY

Review of direct-acting antiviral agents for the treatment of chronic hepatitis C

(2013) Nihar Shah et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Mechanism of action of ribavirin in anti-HCV regimens: new insights for an age-old question?

(2013) Barbara Testoni et al.   GUT

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver

(2013) Stefan Wieland et al.   HEPATOLOGY

Sofosbuvir and Ribavirin for Hepatitis C Genotype 1 in Patients With Unfavorable Treatment Characteristics

(2013) Anuoluwapo Osinusi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emerging concepts in immunity to hepatitis C virus infection

(2013) Hugo R. Rosen   JOURNAL OF CLINICAL INVESTIGATION

IFN-γ production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells

(2013) Shuye Zhang et al.   JOURNAL OF HEPATOLOGY

IFNL4-ΔG Genotype Is Associated With Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated With Sofosbuvir and Ribavirin

(2013) Eric G. Meissner et al.   JOURNAL OF INFECTIOUS DISEASES

Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

(2013) Peter V. Aka et al.   JOURNAL OF INFECTIOUS DISEASES

Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial

(2013) Kris V Kowdley et al.   LANCET

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus–induced microRNAs

(2013) Adelle P McFarland et al.   NATURE IMMUNOLOGY

Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

(2013) Barbara Rehermann   NATURE MEDICINE

Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options

(2013) Ira M. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current and Future Therapies for Hepatitis C Virus Infection

(2013) T. Jake Liang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C

(2013) Edward J. Gane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

(2013) Eric Lawitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue Samples

(2013) Ahmad Amanzada et al.   PLoS One

Hepatic Cell–Type Specific Gene Expression Better Predicts HCV Treatment Outcome Than IL28B Genotype

(2012) Ian McGilvray et al.   GASTROENTEROLOGY

Interferon-γ–Stimulated Genes, but Not USP18, Are Expressed in Livers of Patients With Acute Hepatitis C

(2012) Michael T. Dill et al.   GASTROENTEROLOGY

HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons

(2012) Emmanuel Thomas et al.   GASTROENTEROLOGY

Human Type 2 Myeloid Dendritic Cells Produce Interferon-λ and Amplify Interferon-α in Response to Hepatitis C Virus Infection

(2012) Shuye Zhang et al.   GASTROENTEROLOGY

Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection

(2012) Daryl T.–Y. Lau et al.   GASTROENTEROLOGY

Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation

(2012) Deborah L. Diamond et al.   HEPATOLOGY

Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication

(2012) Philippe Metz et al.   HEPATOLOGY

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry

(2012) Courtney Wilkins et al.   HEPATOLOGY

Does IL28B genotyping still have a role in the era of direct-acting antiviral therapy for chronic hepatitis C infection?

(2012) J. A. Holmes et al.   JOURNAL OF VIRAL HEPATITIS

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo

(2011) Zuzanna Makowska et al.   HEPATOLOGY

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV

(2011) Nigel J. Stevenson et al.   PLoS One

Interferon-lambda and therapy for chronic hepatitis C virus infection

(2011) Raymond P. Donnelly et al.   TRENDS IN IMMUNOLOGY

Ribavirin Improves Early Responses to Peginterferon Through Improved Interferon Signaling

(2010) Jordan J. Feld et al.   GASTROENTEROLOGY

Comparative Analysis of the Lambda-Interferons IL-28A and IL-29 regarding Their Transcriptome and Their Antiviral Properties against Hepatitis C Virus

(2010) Julia Diegelmann et al.   PLoS One

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

Interferon signaling and treatment outcome in chronic hepatitis C

(2008) M. Sarasin-Filipowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA