Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 209, Issue 3, Pages 350-354Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit433
Keywords
genetic; HCV; IFNL4; IL28B; viral clearance
Categories
Funding
- Intramural Research Program of the National Institutes of Health (National Cancer Institute, Division of Cancer Epidemiology and Genetics)
- National Institute of Allergy and Infectious Diseases [U01-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [UO1-HD-32632]
- National Cancer Institute
- National Institute on Drug Abuse
- National Institute on Deafness and Other Communication Disorders
- National Center for Research Resources (UCSF-CTSI frant) [UL1 RR024131]
- National Institutes of Drug Abuse [DA033541, DA12568, DA04334]
- National Institutes of Health [R01-DA09532, R01-DA12109, R01-DA13245, R01-DA16159]
- National Cancer Institute [N02-CP-91027, N01-CO-12400]
- Substance Abuse and Mental Health Services Administration [H79-TI12103]
- [R01013324]
Ask authors/readers for more resources
Interferon lambda 4 protein can be generated in IFNL4-Delta G carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 x 10(-5)) than IFNL4-TT/Delta G (11.3%; OR, 0.95; P = .86) or IFNL4-Delta G/Delta G (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 x 10(-14)) for IFNL4-TT/TT and 1.44 (P = .03) IFNL4-TT/Delta G, and the area under the curve was 0.64 for IFNL4-Delta G genotype and 0.61 for rs12979860 (IL28B). IFNL4-Delta G is strongly associated with impaired spontaneous HCV clearance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
