Myeloid cells as therapeutic targets in neuroinflammation after stroke: Specific roles of neutrophils and neutrophil–platelet interactions

Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia

(2018) Juan G. Zarruk et al.   EXPERIMENTAL NEUROLOGY

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C − Cells

(2017) Alexander Mildner et al.   IMMUNITY

Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance

(2017) Juana Vallés et al.   THROMBOSIS AND HAEMOSTASIS

Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease

(2016) Andrew D. Greenhalgh et al.   BRAIN BEHAVIOR AND IMMUNITY

Azithromycin protects mice against ischemic stroke injury by promoting macrophage transition towards M2 phenotype

(2016) Diana Amantea et al.   EXPERIMENTAL NEUROLOGY

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

(2016) Lidia Garcia-Bonilla et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Antigen Presentation After Stroke

(2016) Francesc Miró-Mur et al.   Neurotherapeutics

Thromboinflammation in Stroke Brain Damage

(2016) Simon F. De Meyer et al.   STROKE

Aging: A Temporal Dimension for Neutrophils

(2016) José M. Adrover et al.   TRENDS IN IMMUNOLOGY

Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells

(2016) Jong Youl Kim et al.   Experimental Neurobiology

P-selectin promotes neutrophil extracellular trap formation in mice

(2015) J. Etulain et al.   BLOOD

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke

(2015) Michael Gliem et al.   GLIA

Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies

(2015) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia

(2015) Ana Moraga et al.   Journal of Neuroinflammation

Functional differences between microglia and monocytes after ischemic stroke

(2015) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Early Dynamics of P-selectin and Interleukin 6 Predicts Outcomes in Ischemic Stroke

(2015) Gabriella Pusch et al.   Journal of Stroke & Cerebrovascular Diseases

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia

(2015) Lijuan Han et al.   STROKE

Evidence That Ly6ChiMonocytes Are Protective in Acute Ischemic Stroke by Promoting M2 Macrophage Polarization

(2015) Hannah X. Chu et al.   STROKE

The role of platelets in inflammation

(2015) Robert Storey et al.   THROMBOSIS AND HAEMOSTASIS

Early Dynamics of P-selectin and Interleukin 6 Predicts Outcomes in Ischemic Stroke

(2015) Gabriella Pusch et al.   Journal of Stroke & Cerebrovascular Diseases

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

(2015) Diana Amantea et al.   Frontiers in Neuroscience

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Understanding the Multifaceted Role of Inflammatory Mediators in Ischemic Stroke

(2014) D. Amantea et al.   CURRENT MEDICINAL CHEMISTRY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Role of CCR2 in Inflammatory Conditions of the Central Nervous System

(2014) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

(2014) Zhiwei Tang et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Differences in the Phagocytic Response of Microglia and Peripheral Macrophages after Spinal Cord Injury and Its Effects on Cell Death

(2014) A. D. Greenhalgh et al.   JOURNAL OF NEUROSCIENCE

Platelets in inflammation and immunity

(2014) J. M. Herter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Exendin-4 Reduces Ischemic Brain Injury in Normal and Aged Type 2 Diabetic Mice and Promotes Microglial M2 Polarization

(2014) Vladimer Darsalia et al.   PLoS One

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

(2014) Kakali Ghoshal et al.   TheScientificWorldJOURNAL

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII

(2013) L. Faxalv et al.   BLOOD

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

S1PR5 is pivotal for the homeostasis of patrolling monocytes

(2013) Emilie Debien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

(2013) Sylvie Girard et al.   GLIA

Platelets: bridging hemostasis, inflammation, and immunity

(2013) C. N. Jenne et al.   International Journal of Laboratory Hematology

Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR  and 5-LO-dependent pathways

(2013) I. Ballesteros et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Bone Marrow Cell Recruitment to the Brain in the Absence of Irradiation or Parabiosis Bias

(2013) Katrin Kierdorf et al.   PLoS One

Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil

(2013) Chunyun Liu et al.   PLoS One

Relevance of Distinct Monocyte Subsets to Clinical Course of Ischemic Stroke Patients

(2013) Muichi Kaito et al.   PLoS One

Neutrophils in innate and adaptive immunity

(2013) Sébastien Jaillon et al.   Seminars in Immunopathology

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

(2013) María Isabel Cuartero et al.   STROKE

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

(2012) Michael Gliem et al.   ANNALS OF NEUROLOGY

Brain-Immune Interactions and Ischemic Stroke

(2012) Costantino Iadecola   ARCHIVES OF NEUROLOGY

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation

(2012) J. H. Morrissey et al.   BLOOD

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice

(2012) D. Duerschmied et al.   BLOOD

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Detection and Distribution of Microglial and Hematogenous Macrophage Populations in the Injured Spinal Cord oflys-EGFP-kiTransgenic Mice

(2012) Leah A. Mawhinney et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Platelet-leukocyte crosstalk: Linking proinflammatory responses to procoagulant state

(2012) Mehran Ghasemzadeh et al.   THROMBOSIS RESEARCH

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

The role of TLRs in neutrophil activation

(2011) Lynne R Prince et al.   CURRENT OPINION IN PHARMACOLOGY

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

(2011) Cynthia Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for spleen monocytes in post-ischemic brain inflammation and injury

(2011) Yi Bao et al.   Journal of Neuroinflammation

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Platelet interleukin-1  drives cerebrovascular inflammation

(2010) P. Thornton et al.   BLOOD

Chemokine-related gene expression in the brain following ischemic stroke: No role for CXCR2 in outcome

(2010) Vanessa H. Brait et al.   BRAIN RESEARCH

Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema

(2010) Yuka Ikegame et al.   HYPERTENSION RESEARCH

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Toward a functional characterization of blood monocytes

(2010) Prakash Saha et al.   IMMUNOLOGY AND CELL BIOLOGY

Experimental Stroke-Induced Changes in the Bone Marrow Reveal Complex Regulation of Leukocyte Responses

(2010) Adam Denes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Marrow-Derived Cells Contribute to Vascular Endothelial Growth Factor–Induced Angiogenesis in the Adult Mouse Brain by Supplying Matrix Metalloproteinase-9

(2010) Qi Hao et al.   STROKE

Platelets as initiators and mediators of inflammation at the vessel wall

(2010) Guanfang Shi et al.   THROMBOSIS RESEARCH

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Effects of G-CSF treatment on neutrophil mobilization and neurological outcome after transient focal ischemia

(2009) Jan-Kolja Strecker et al.   EXPERIMENTAL NEUROLOGY

Monocyte Subtypes Predict Clinical Course and Prognosis in Human Stroke

(2009) Xabier Urra et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

(2009) Alessandro Michelucci et al.   JOURNAL OF NEUROIMMUNOLOGY

Platelet functions beyond hemostasis

(2009) S. S. SMYTH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

(2009) Ann M. Stowe et al.   NEUROBIOLOGY OF DISEASE

Monocytes Are Major Players in the Prognosis and Risk of Infection After Acute Stroke

(2009) Xabier Urra et al.   STROKE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

A new penumbra: transitioning from injury into repair after stroke

(2008) Eng H Lo   NATURE MEDICINE

Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines

(2008) Basam Z. Barkho et al.   STEM CELLS