Platelets in inflammation and immunity

Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13

(2014) Bente Halvorsen et al.   ATHEROSCLEROSIS

The Role of P2Y12 Receptor and Activated Platelets During Inflammation

(2014) Elisabetta Liverani et al.   CURRENT DRUG TARGETS

Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps

(2014) Markus Bosmann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lipopolysaccharide Is a Direct Agonist for Platelet RNA Splicing

(2014) P. N. Shashkin et al.   JOURNAL OF IMMUNOLOGY

MC-002 exhibits positive effects against platelets aggregation and endothelial dysfunction through thromboxane A 2 inhibition

(2014) Weirong Fang et al.   THROMBOSIS RESEARCH

Activated platelets can deliver mRNA regulatory Ago2bulletmicroRNA complexes to endothelial cells via microparticles

(2013) B. Laffont et al.   BLOOD

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

Response: platelet transcriptome and proteome--relation rather than correlation

(2013) J. Geiger et al.   BLOOD

Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression

(2013) O. Gidlof et al.   BLOOD

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Effect of CD40 and sCD40L on Renal Function and Survival in Patients With Renal Artery Stenosis

(2013) Steven T. Haller et al.   HYPERTENSION

Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation

(2013) Clive Page et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activated Platelets Enhance IL-10 Secretion and Reduce TNF-  Secretion by Monocytes

(2013) S. Gudbrandsdottir et al.   JOURNAL OF IMMUNOLOGY

Platelet-Secreted MicroRNA-223 Promotes Endothelial Cell Apoptosis Induced by Advanced Glycation End Products via Targeting the Insulin-like Growth Factor 1 Receptor

(2013) Y. Pan et al.   JOURNAL OF IMMUNOLOGY

The Uncoupling of Monocyte-Platelet Interactions from the Induction of Proinflammatory Signaling in Monocytes

(2013) J. Stephen et al.   JOURNAL OF IMMUNOLOGY

Functional consequences of platelet binding to T lymphocytes in inflammation

(2013) Carlos Zamora et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis

(2013) Fredrik Kahn et al.   MICROBES AND INFECTION

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis

(2013) Milladur Rahman et al.   PLATELETS

Soluble CD40 Ligand Stimulates CD40-Dependent Activation of the β2 Integrin Mac-1 and Protein Kinase C Zeda (PKCζ) in Neutrophils: Implications for Neutrophil-Platelet Interactions and Neutrophil Oxidative Burst

(2013) Rong Jin et al.   PLoS One

Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion

(2013) Dirk Lievens et al.   THROMBOSIS AND HAEMOSTASIS

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway

(2013) Binggang Xiang et al.   Nature Communications

Therapeutic Administration of the Direct Thrombin Inhibitor Argatroban Reduces Hepatic Inflammation in Mice with Established Fatty Liver Disease

(2012) Karen M. Kassel et al.   AMERICAN JOURNAL OF PATHOLOGY

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice

(2012) Tanja Schönberger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Disruption of Platelet-derived Chemokine Heteromers Prevents Neutrophil Extravasation in Acute Lung Injury

(2012) Jochen Grommes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice

(2012) G. M. Thomas et al.   BLOOD

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Platelets and platelet-like particles mediate intercellular RNA transfer

(2012) A. Risitano et al.   BLOOD

NETs Tangle with HIV

(2012) Craig N. Jenne et al.   Cell Host & Microbe

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion

(2012) Julien Berthet et al.   CLINICAL IMMUNOLOGY

Metalloproteinases regulate CD40L shedding from platelets and pulmonary recruitment of neutrophils in abdominal sepsis

(2012) Milladur Rahman et al.   INFLAMMATION RESEARCH

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa Sepsis

(2012) Martina Kalle et al.   PLoS One

Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum

(2012) B. J. McMorran et al.   SCIENCE

Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse

(2012) Licia Totani et al.   THROMBOSIS AND HAEMOSTASIS

Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet  -granules

(2011) J. Kamykowski et al.   BLOOD

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity

(2011) S. Nagalla et al.   BLOOD

Long-term clinical outcomes of patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study

(2011) M. Norgaard et al.   BLOOD

Major Contribution of the P2Y 1 Receptor in Purinergic Regulation of TNFα-Induced Vascular Inflammation

(2011) Murielle Zerr et al.   CIRCULATION

Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injury

(2011) P. R. Tuinman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

(2011) Diego Mourão-Sá et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Efficient phagocytosis of periodontopathogens by neutrophils requires plasma factors, platelets and TLR2

(2011) A. ASSINGER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clopidogrel, a P2Y12 Receptor Antagonist, Potentiates the Inflammatory Response in a Rat Model of Peptidoglycan Polysaccharide-Induced Arthritis

(2011) Analia E. Garcia et al.   PLoS One

Monocyte-Platelet Interaction Induces a Pro-Inflammatory Phenotype in Circulating Monocytes

(2011) Gabriella Passacquale et al.   PLoS One

The roles of thrombin and protease-activated receptors in inflammation

(2011) Liang Ma et al.   Seminars in Immunopathology

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

(2011) Adriana Vieira-de-Abreu et al.   Seminars in Immunopathology

Platelets regulate CD4+ T-cell differentiation via multiple chemokines in humans

(2011) Norbert Gerdes et al.   THROMBOSIS AND HAEMOSTASIS

Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients

(2011) Maria Lukasik et al.   THROMBOSIS RESEARCH

Neutrophils and Intravascular Immunity in the Liver during Infection and Sterile Inflammation

(2011) Braedon McDonald et al.   TOXICOLOGIC PATHOLOGY

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

(2011) Bjoern F. Kraemer et al.   PLoS Pathogens

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

(2010) Hervé Falet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets

(2010) Christopher M Scull et al.   Journal of Inflammation-London

Impact of glycoprotein VI and platelet adhesion on atherosclerosis—A possible role of fibronectin

(2010) Andreas Bültmann et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Immature myeloid dendritic cells capture and remove activated platelets from preformed aggregates

(2010) B. MAÎTRE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Streptococcal M1 Protein-Induced Lung Injury is Independent of Platelets in Mice

(2010) Su Zhang et al.   SHOCK

Adenosine Diphosphate Receptor Antagonist Clopidogrel Sulfate Attenuates LPS-Induced Systemic Inflammation in a Rat Model

(2010) Satoshi Hagiwara et al.   SHOCK

Platelet CD40L at the interface of adaptive immunity

(2010) Bennett D. Elzey et al.   THROMBOSIS RESEARCH

Thrombin Inhibition During Kidney Ischemia-Reperfusion Reduces Chronic Graft Inflammation and Tubular Atrophy

(2010) Raphael Thuillier et al.   TRANSPLANTATION

Platelets in defense against bacterial pathogens

(2009) Michael R. Yeaman   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway

(2009) G. Zhang et al.   JOURNAL OF IMMUNOLOGY

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

Inflammation induces hemorrhage in thrombocytopenia

(2008) T. Goerge et al.   BLOOD

Direct contact of platelets and their released products exert different effects on human dendritic cell maturation

(2008) Hind Hamzeh-Cognasse et al.   BMC IMMUNOLOGY

Platelets as versatile regulators of cutaneous inflammation

(2008) Norito Katoh   JOURNAL OF DERMATOLOGICAL SCIENCE

Platelet-lymphocyte cross-talk

(2008) Nailin Li   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases

(2008) J. M. van Gils et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'

(2008) Christian J Kastrup et al.   Nature Chemical Biology

Thrombocytes respond to lipopolysaccharide through Toll-like receptor-4, and MAP kinase and NF-κB pathways leading to expression of interleukin-6 and cyclooxygenase-2 with production of prostaglandin E2

(2007) Tom Scott et al.   MOLECULAR IMMUNOLOGY