Recombinant Human Interleukin-1 Receptor Antagonist in Severe Traumatic Brain Injury: A Phase II Randomized Control Trial

Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications

(2013) Richard J. Shannon et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

(2013) Anthony Cahn et al.   BMC Pharmacology & Toxicology

Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis

(2012) Marc Weidenbusch et al.   Journal of Innate Immunity

Design and Synthesis of a Series of Pyrido[2,3-d]pyrimidine Derivatives as CCR4 Antagonists

(2012) Hongwei Gong et al.   MOLECULES

Principal Component Analysis of the Cytokine and Chemokine Response to Human Traumatic Brain Injury

(2012) Adel Helmy et al.   PLoS One

Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

(2011) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury

(2011) Adel Helmy et al.   PROGRESS IN NEUROBIOLOGY

Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue

(2010) Olivia Osborn et al.   CYTOKINE

The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

(2010) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Intravenous Anakinra can Achieve Experimentally Effective Concentrations in the Central Nervous System within a Therapeutic Time Window: Results of a Dose-Ranging Study

(2010) James Galea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exploring New Routes for Neuroprotective Drug Development in Traumatic Brain Injury

(2010) T. Janowitz et al.   Science Translational Medicine

Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

(2009) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immune response deviation and enhanced expression of chemokine receptor CCR4 in TBI patients due to unknown serum factors

(2009) Dieter Cadosch et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Microdialysis of Cytokines: Methodological Considerations, Scanning Electron Microscopy, and Determination of Relative Recovery

(2009) Adel Helmy et al.   JOURNAL OF NEUROTRAUMA

Classification of Traumatic Brain Injury for Targeted Therapies

(2008) Kathryn E. Saatman et al.   JOURNAL OF NEUROTRAUMA

Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity

(2008) M. Schwartz et al.   NEUROSCIENCE