Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation

(2012) Panayiotis A. Procopiou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting chemokine receptors in allergic disease

(2011) James E. Pease   BIOCHEMICAL JOURNAL

A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

(2011) H. Pere et al.   BLOOD

The Role of Cytokines in Atopic Asthma

(2011) M. Finiasz et al.   CURRENT MEDICINAL CHEMISTRY

Monoclonal antibodies for the treatment of asthma

(2011) Matthew C. Catley et al.   PHARMACOLOGY & THERAPEUTICS

RS-1748, a Novel CC Chemokine Receptor 4 Antagonist, Inhibits Ovalbumin-Induced Airway Inflammation in Guinea Pigs

(2010) Yasuhiro Nakagami et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma

(2010) Kazuhito Yamamoto et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients

(2010) P. Vijayanand et al.   JOURNAL OF IMMUNOLOGY

Immunomodulators in the treatment of asthma

(2009) Aidan A. Long   ALLERGY AND ASTHMA PROCEEDINGS

Immunobiology of Asthma

(2009) Qutayba Hamid et al.   Annual Review of Physiology

Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice

(2009) Yasuhiro Nakagami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mast cells and eosinophils: the two key effector cells in allergic inflammation

(2009) Yael Minai-Fleminger et al.   INFLAMMATION RESEARCH

Asthma

(2009) Christopher H. Fanta   NEW ENGLAND JOURNAL OF MEDICINE

Inhibitory Effect of the New Orally Active CCR4 Antagonist K327 on CCR4+CD4+ T Cell Migration into the Lung of Mice with Ovalbumin-Induced Lung Allergic Inflammation

(2009) Takashi Sato et al.   PHARMACOLOGY

Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

(2009) Matthew N. Davies et al.   PLoS One

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

(2008) J. Bayry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA