Enhancingmda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery

MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors

(2010) Adly Yacoub et al.   CANCER BIOLOGY & THERAPY

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

(2010) Margaret A. Park et al.   CANCER BIOLOGY & THERAPY

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24

(2010) Luni Emdad et al.   CANCER BIOLOGY & THERAPY

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

(2010) Hossein A. Hamed et al.   CANCER BIOLOGY & THERAPY

Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells

(2010) R Dash et al.   CANCER GENE THERAPY

PERK-Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24-Induced Killing of Primary Human Glioblastoma Multiforme Cells

(2010) A. Yacoub et al.   CANCER RESEARCH

Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

(2010) Rupesh Dash et al.   CANCER RESEARCH

Inhibition of Multiple Protective Signaling Pathways and Ad.5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma

(2010) Hossein A Hamed et al.   MOLECULAR THERAPY

Treatment of metastatic renal cell carcinoma

(2010) Maxine Sun et al.   Nature Reviews Urology

Sorafenib for Treatment of Renal Cell Carcinoma: Final Efficacy and Safety Results of the Phase III Treatment Approaches in Renal Cancer Global Evaluation Trial

(2009) Bernard Escudier et al.   JOURNAL OF CLINICAL ONCOLOGY

MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism

(2009) M. A. Park et al.   MOLECULAR CANCER THERAPEUTICS

Cisplatin Enhances Protein Kinase R-Like Endoplasmic Reticulum Kinase- and CD95-Dependent Melanoma Differentiation-Associated Gene-7/Interleukin-24-Induced Killing in Ovarian Carcinoma Cells

(2009) A. Yacoub et al.   MOLECULAR PHARMACOLOGY

Prognostic factors and long-term survival in renal cell cancer patients

(2009) Kaisa L. Sunela et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling

(2008) Guo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

(2008) A. Yacoub et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

(2008) A. Yacoub et al.   MOLECULAR CANCER THERAPEUTICS