Establishment of epithelial polarity – GEF who's minding the GAP?

Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl

(2014) Jinwei Zhu et al.   CELL RESEARCH

ERM proteins at a glance

(2014) Andrea I. McClatchey   JOURNAL OF CELL SCIENCE

Integrins and epithelial cell polarity

(2014) Jessica L. Lee et al.   JOURNAL OF CELL SCIENCE

MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly

(2014) Laurent Guillemot et al.   MOLECULAR BIOLOGY OF THE CELL

The WD40 protein Morg1 facilitates Par6–aPKC binding to Crb3 for apical identity in epithelial cells

(2013) Junya Hayase et al.   JOURNAL OF CELL BIOLOGY

Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation

(2013) Ceniz Zihni et al.   JOURNAL OF CELL BIOLOGY

TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function

(2013) S. P. Ngok et al.   JOURNAL OF CELL SCIENCE

NG2 Regulates Directional Migration of Oligodendrocyte Precursor Cells via Rho GTPases and Polarity Complex Proteins

(2013) F. Biname et al.   JOURNAL OF NEUROSCIENCE

Crumbs3 Is Essential for Proper Epithelial Development and Viability

(2013) E. L. Whiteman et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration

(2013) J. C. Dachsel et al.   MOLECULAR AND CELLULAR BIOLOGY

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

Transforming mutations of RAC guanosine triphosphatases in human cancers

(2013) M. Kawazu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive Feedback and Mutual Antagonism Combine to Polarize Crumbs in the Drosophila Follicle Cell Epithelium

(2012) Georgina C. Fletcher et al.   CURRENT BIOLOGY

Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity

(2012) C. Penalva et al.   DEVELOPMENT

Scribble is required for normal epithelial cell–cell contacts and lumen morphogenesis in the mammalian lung

(2012) Laura L. Yates et al.   DEVELOPMENTAL BIOLOGY

Regulation of Microtubule Stability and Organization by Mammalian Par3 in Specifying Neuronal Polarity

(2012) She Chen et al.   DEVELOPMENTAL CELL

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis

(2012) Pradeep S. Tanwar et al.   HUMAN MOLECULAR GENETICS

DrosophilaPATJ supports adherens junction stability by modulating Myosin light chain activity

(2012) Arnab Sen et al.   JOURNAL OF CELL BIOLOGY

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

(2012) Sandra Iden et al.   JOURNAL OF CELL BIOLOGY

VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

(2012) Siu P. Ngok et al.   JOURNAL OF CELL BIOLOGY

Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1–HSP90

(2012) Dennis J. Eastburn et al.   JOURNAL OF CELL SCIENCE

Mutation inMPDZcauses severe congenital hydrocephalus

(2012) Mohammed S Al-Dosari et al.   JOURNAL OF MEDICAL GENETICS

The Signaling Adaptor Gab1 Regulates Cell Polarity by Acting as a PAR Protein Scaffold

(2012) Ziqiang Yang et al.   MOLECULAR CELL

Role of membrane traffic in the generation of epithelial cell asymmetry

(2012) Gerard Apodaca et al.   NATURE CELL BIOLOGY

Rap2A links intestinal cell polarity to brush border formation

(2012) Martijn Gloerich et al.   NATURE CELL BIOLOGY

Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity

(2012) Julia Franziska Winter et al.   NATURE CELL BIOLOGY

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell–cell junctions by differentially regulating Tiam1 activity

(2012) Natalie A. Mack et al.   NATURE CELL BIOLOGY

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

(2012) Aparna Ratheesh et al.   NATURE CELL BIOLOGY

Chimaerin Suppresses Rac1 Activation at the Apical Membrane to Maintain the Cyst Structure

(2012) Shunsuke Yagi et al.   PLoS One

The Scribble Polarity Protein Stabilizes E-Cadherin/p120-Catenin Binding and Blocks Retrieval of E-Cadherin to the Golgi

(2012) Madhura Lohia et al.   PLoS One

Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-Myosin II signaling

(2012) M. Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions

(2011) Chunling Yi et al.   CANCER CELL

Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane

(2011) Simon Wang et al.   DEVELOPMENTAL BIOLOGY

Dlg3 Trafficking and Apical Tight Junction Formation Is Regulated by Nedd4 and Nedd4-2 E3 Ubiquitin Ligases

(2011) Claude A. Van Campenhout et al.   DEVELOPMENTAL CELL

Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF

(2011) Hiroyuki Nakajima et al.   JOURNAL OF CELL BIOLOGY

Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation

(2011) Takashi Ishiuchi et al.   NATURE CELL BIOLOGY

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell Polarity in Eggs and Epithelia: Parallels and Diversity

(2010) Daniel St Johnston et al.   CELL

aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells

(2010) Eurico Morais-de-Sá et al.   CELL

Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling

(2010) Rhian F. Walther et al.   CURRENT BIOLOGY

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

Bazooka is required for polarisation of the Drosophila anterior-posterior axis

(2010) H. Doerflinger et al.   DEVELOPMENT

Crumbs is required to achieve proper organ size control during Drosophila head development

(2010) E. C. N. Richardson et al.   DEVELOPMENT

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

A novel role for 14-3-3  in regulating epithelial cell polarity

(2010) C. Ling et al.   GENES & DEVELOPMENT

Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation

(2010) Yi Qin et al.   JOURNAL OF CELL BIOLOGY

Formation of a Bazooka–Stardust complex is essential for plasma membrane polarity in epithelia

(2010) Michael P. Krahn et al.   JOURNAL OF CELL BIOLOGY

A molecular network for de novo generation of the apical surface and lumen

(2010) David M. Bryant et al.   NATURE CELL BIOLOGY

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium

(2009) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of an Aurora-A/PinsLINKER/ Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells

(2009) Christopher A. Johnston et al.   CELL

Par3 and Dynein Associate to Regulate Local Microtubule Dynamics and Centrosome Orientation during Migration

(2009) Jan Schmoranzer et al.   CURRENT BIOLOGY

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells

(2009) Y. Horikoshi et al.   JOURNAL OF CELL SCIENCE

Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins

(2009) M. Adachi et al.   MOLECULAR AND CELLULAR BIOLOGY

EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell–Cell Contacts

(2009) Koichi Miura et al.   MOLECULAR BIOLOGY OF THE CELL

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widely Conserved Signaling Pathways in the Establishment of Cell Polarity

(2009) L. M. McCaffrey et al.   Cold Spring Harbor Perspectives in Biology

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells

(2008) M. Ernkvist et al.   BLOOD

Syx, a RhoA Guanine Exchange Factor, Is Essential for Angiogenesis In Vivo

(2008) Maija K. Garnaas et al.   CIRCULATION RESEARCH

Cdc42, Par6, and aPKC Regulate Arp2/3-Mediated Endocytosis to Control Local Adherens Junction Stability

(2008) Marios Georgiou et al.   CURRENT BIOLOGY

The PAR-6 Polarity Protein Regulates Dendritic Spine Morphogenesis through p190 RhoGAP and the Rho GTPase

(2008) Huaye Zhang et al.   DEVELOPMENTAL CELL

EFA6 Facilitates the Assembly of the Tight Junction by Coordinating an Arf6-dependent and -independent Pathway

(2008) Stéphanie Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability

(2008) N. Narayan et al.   JOURNAL OF CELL SCIENCE

The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1

(2008) Marcel A. Estvez et al.   JOURNAL OF NEUROCHEMISTRY

Paracingulin Regulates the Activity of Rac1 and RhoA GTPases by Recruiting Tiam1 and GEF-H1 to Epithelial Junctions

(2008) Laurent Guillemot et al.   MOLECULAR BIOLOGY OF THE CELL

Crosstalk between small GTPases and polarity proteins in cell polarization

(2008) Sandra Iden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes

(2008) E L Whiteman et al.   ONCOGENE

Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association

(2008) J. L. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarization of the C. elegans Embryo by RhoGAP-Mediated Exclusion of PAR-6 from Cell Contacts

(2008) D. C. Anderson et al.   SCIENCE