GSK3-β promotes calpain-1–mediated desmin filament depolymerization and myofibril loss in atrophy

Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization

(2017) Alexandra Volodin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3- and PRMT-1–dependent modifications of desmoplakin control desmoplakin–cytoskeleton dynamics

(2015) Lauren V. Albrecht et al.   JOURNAL OF CELL BIOLOGY

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Desmin modifications associate with amyloid-like oligomers deposition in heart failure

(2014) Giulio Agnetti et al.   CARDIOVASCULAR RESEARCH

GSK3 Protein Positively Regulates Type I Insulin-like Growth Factor Receptor through Forkhead Transcription Factors FOXO1/3/4

(2014) Xiaodong Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

(2014) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

(2014) H. Tang et al.   Science Signaling

Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components

(2014) Xin Ye et al.   PLoS Pathogens

The effects of Capn1 gene inactivation on skeletal muscle growth, development, and atrophy, and the compensatory role of other proteolytic systems1

(2013) C. M. Kemp et al.   JOURNAL OF ANIMAL SCIENCE

De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy

(2013) L. A. Cea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy

(2012) Matthew B. Hudson et al.   CRITICAL CARE MEDICINE

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Inactivation of the Enzyme GSK3α by the Kinase IKKi Promotes AKT-mTOR Signaling Pathway that Mediates Interleukin-1-Induced Th17 Cell Maintenance

(2012) Muhammet F. Gulen et al.   IMMUNITY

Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature

(2012) S. Hata et al.   JOURNAL OF BIOCHEMISTRY

Monoubiquitination Promotes Calpain Cleavage of the Protein Phosphatase 2A (PP2A) Regulatory Subunit α4, Altering PP2A Stability and Microtubule-associated Protein Phosphorylation

(2012) Guy R. Watkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy

(2011) Koen J. P. Verhees et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states

(2010) Daniel J. Macqueen et al.   GENE

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme

(2009) Ying-Hao Chou et al.   FASEB JOURNAL

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Calpain-1 is required for hydrogen peroxide-induced myotube atrophy

(2008) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calpain activity and muscle wasting in sepsis

(2008) Ira J. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization

(2008) Manolis Mavroidis et al.   FASEB JOURNAL

A Myopathy-linked Desmin Mutation Perturbs Striated Muscle Actin Filament Architecture

(2008) Gloria M. Conover et al.   MOLECULAR BIOLOGY OF THE CELL