The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms

Distinct Regulation of Integrin-Dependent T Cell Conjugate Formation and NF- B Activation by the Adapter Protein ADAP

(2014) B. J. Burbach et al.   JOURNAL OF IMMUNOLOGY

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

(2013) N. P. Coussens et al.   MOLECULAR AND CELLULAR BIOLOGY

Two modes of integrin activation form a binary molecular switch in adhesion maturation

(2013) Ho-Sup Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Dual-color superresolution microscopy reveals nanoscale organization of mechanosensory podosomes

(2013) K. van den Dries et al.   MOLECULAR BIOLOGY OF THE CELL

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function

(2012) Jia-huai Wang et al.   IMMUNOLOGICAL REVIEWS

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells

(2012) P. T. Sage et al.   JOURNAL OF IMMUNOLOGY

XRCC4's interaction with XLF is required for coding (but not signal) end joining

(2012) S. Roy et al.   NUCLEIC ACIDS RESEARCH

Non-Catalytic Functions of Pyk2 and Fyn Regulate Late Stage Adhesion in Human T Cells

(2012) Nicole M. Chapman et al.   PLoS One

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules

(2011) S. Kliche et al.   BLOOD

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

(2011) Nuria Martínez-Martín et al.   IMMUNITY

SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1

(2011) Monika Raab et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

(2011) Rémi Lasserre et al.   JOURNAL OF CELL BIOLOGY

The Pleckstrin Homology Domain in the SKAP55 Adapter Protein Defines the Ability of the Adapter Protein ADAP To Regulate Integrin Function and NF- B Activation

(2011) B. J. Burbach et al.   JOURNAL OF IMMUNOLOGY

Functional Cooperation between the Proteins Nck and ADAP Is Fundamental for Actin Reorganization

(2011) M. H. Pauker et al.   MOLECULAR AND CELLULAR BIOLOGY

Vav1-Mediated Scaffolding Interactions Stabilize SLP-76 Microclusters and Contribute to Antigen-Dependent T Cell Responses

(2011) N. R. Sylvain et al.   Science Signaling

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse

(2010) Rémi Lasserre et al.   EMBO JOURNAL

Cooperative interactions at the SLP-76 complex are critical for actin polymerization

(2010) Mira Barda-Saad et al.   EMBO JOURNAL

T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes

(2010) Monika Raab et al.   IMMUNITY

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

PtdIns(3,4)P2 instigates focal adhesions to generate podosomes

(2010) Tsukasa Oikawa et al.   Cell Adhesion & Migration

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions

(2009) C. Albiges-Rizo et al.   JOURNAL OF CELL SCIENCE

Hematopoietic Lineage Cell-Specific Protein 1 Is Recruited to the Immunological Synapse by IL-2-Inducible T Cell Kinase and Regulates Phospholipase C 1 Microcluster Dynamics during T Cell Spreading

(2009) E. Carrizosa et al.   JOURNAL OF IMMUNOLOGY

The Adapter Protein SLP-76 Mediates "Outside-In" Integrin Signaling and Function in T Cells

(2009) R. G. Baker et al.   MOLECULAR AND CELLULAR BIOLOGY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Assembly and biological role of podosomes and invadopodia

(2008) Mario Gimona et al.   CURRENT OPINION IN CELL BIOLOGY

Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion

(2008) Laura Machesky et al.   EMBO REPORTS

Podosome-type adhesions and focal adhesions, so alike yet so different

(2008) M BLOCK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Rho GTPases in osteoclasts: Orchestrators of podosome arrangement

(2008) S ORY et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

T Cell Costimulation via the Integrin VLA-4 Inhibits the Actin-Dependent Centralization of Signaling Microclusters Containing the Adaptor SLP-76

(2008) Ken Nguyen et al.   IMMUNITY

Signal initiation in T-cell receptor microclusters

(2008) Maria-Cristina Seminario et al.   IMMUNOLOGICAL REVIEWS

ASAP3 Is a Focal Adhesion-associated Arf GAP That Functions in Cell Migration and Invasion

(2008) Vi Luan Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

(2008) Naohide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Sequential signals toward podosome formation in NIH-src cells

(2008) Tsukasa Oikawa et al.   JOURNAL OF CELL BIOLOGY

How Antigen Quantity and Quality Determine T-Cell Decisions in Lymphoid Tissue

(2008) H. Zheng et al.   MOLECULAR AND CELLULAR BIOLOGY

The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch

(2008) Kenneth D. Swanson et al.   MOLECULAR CELL

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY