Non-Catalytic Functions of Pyk2 and Fyn Regulate Late Stage Adhesion in Human T Cells

Integrin signalling and function in immune cells

(2012) Yanbo Zhang et al.   IMMUNOLOGY

Studying the Dynamics of SLP-76, Nck, and Vav1 Multimolecular Complex Formation in Live Human Cells with Triple-Color FRET

(2012) M. H. Pauker et al.   Science Signaling

Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells

(2011) Joëlle St-Pierre et al.   CELLULAR SIGNALLING

T cell-driven initiation and propagation of autoimmune diabetes

(2011) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases

(2011) Sophia Y. Cleland et al.   FEBS LETTERS

Role of Two Adaptor Molecules SLP-76 and LAT in the PI3K Signaling Pathway in Activated T Cells

(2011) E. K. Shim et al.   JOURNAL OF IMMUNOLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Cooperative interactions at the SLP-76 complex are critical for actin polymerization

(2010) Mira Barda-Saad et al.   EMBO JOURNAL

Multiple pathways leading from the T-cell antigen receptor to the actin cytoskeleton network

(2010) Barak Reicher et al.   FEBS LETTERS

Cytoskeletal cross-talk in the control of T cell antigen receptor signaling

(2010) Rémi Lasserre et al.   FEBS LETTERS

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells

(2010) Michaela Collins et al.   MOLECULAR IMMUNOLOGY

Understanding the Structure and Function of the Immunological Synapse

(2010) M. L. Dustin et al.   Cold Spring Harbor Perspectives in Biology

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

A Pyk2–Vav1 complex is recruited to β3-adhesion sites to initiate Rho activation

(2009) Chunlei Gao et al.   BIOCHEMICAL JOURNAL

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading

(2009) Kathy W. K. Tse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems

(2009) Michaela Collins et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes

(2009) Noemi Cruz-Orcutt et al.   MOLECULAR IMMUNOLOGY

Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells

(2009) Rebekah R. Bartelt et al.   PLoS One

The Actin Cytoskeleton in T Cell Activation

(2008) Janis K. Burkhardt et al.   Annual Review of Immunology

T Cell Costimulation via the Integrin VLA-4 Inhibits the Actin-Dependent Centralization of Signaling Microclusters Containing the Adaptor SLP-76

(2008) Ken Nguyen et al.   IMMUNITY

Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity

(2008) Koh Takeuchi et al.   JOURNAL OF MOLECULAR BIOLOGY

Rational Design Leads to More Potent RNA Interference Against Hepatitis B Virus: Factors Effecting Silencing Efficiency

(2008) Kathy Keck et al.   MOLECULAR THERAPY