Protein Splicing: How Inteins Escape from Precursor Proteins

Structural and Dynamical Features of Inteins and Implications on Protein Splicing

(2014) Ertan Eryilmaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intein Applications: From Protein Purification and Labeling to Metabolic Control Methods

(2014) David W. Wood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enigmatic Distribution, Evolution, and Function of Inteins

(2014) Olga Novikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Internal Disulfide Bond Acts as a Switch for Intein Activity

(2013) Michael C. Nicastri et al.   BIOCHEMISTRY

Structural basis for proteintrans-splicing by a bacterial intein-like domain - protein ligation without nucleophilic side chains

(2013) A. Sesilja Aranko et al.   FEBS Journal

Faster Protein Splicing with theNostoc punctiformeDnaE Intein Using Non-native Extein Residues

(2013) Manoj Cheriyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extein Residues Play an Intimate Role in the Rate-Limiting Step of Protein Trans-Splicing

(2013) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A conserved threonine spring-loads precursor for intein splicing

(2013) Albert K. Dearden et al.   PROTEIN SCIENCE

The Thermococcus kodakaraensis Tko CDC21-1 Intein Activates Its N-Terminal Splice Junction in the Absence of a Conserved Histidine by a Compensatory Mechanism

(2012) Kazuo Tori et al.   BIOCHEMISTRY

Recent progress in intein research: from mechanism to directed evolution and applications

(2012) Gerrit Volkmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unprecedented Rates and Efficiencies Revealed for New Natural Split Inteins from Metagenomic Sources

(2012) Patricia Carvajal-Vallejos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR and Crystal Structures of the Pyrococcus horikoshii RadA Intein Guide a Strategy for Engineering a Highly Efficient and Promiscuous Intein

(2012) Jesper S. Oeemig et al.   JOURNAL OF MOLECULAR BIOLOGY

Intramolecular Disulfide Bond between Catalytic Cysteines in an Intein Precursor

(2012) Wen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrafast Protein Splicing is Common among Cyanobacterial Split Inteins: Implications for Protein Engineering

(2012) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing Intein-Catalyzed Thioester Formation by Unnatural Amino Acid Substitutions in the Active Site

(2011) Dirk Schwarzer et al.   BIOCHEMISTRY

Branched Intermediate Formation Is the Slowest Step in the Protein Splicing Reaction of the Ala1 KlbA Intein fromMethanococcus jannaschii

(2011) Lana Saleh et al.   BIOCHEMISTRY

Electronic Structure of Neighboring Extein Residue Modulates Intein C-Terminal Cleavage Activity

(2011) Philip T. Shemella et al.   BIOPHYSICAL JOURNAL

Intein lacking conserved C-terminal motif G retains controllable N-cleavage activity

(2011) Gerrit Volkmann et al.   FEBS Journal

Expanding the Definition of Class 3 Inteins and Their Proposed Phage Origin

(2011) K. Tori et al.   JOURNAL OF BACTERIOLOGY

pKaCoupling at the Intein Active Site: Implications for the Coordination Mechanism of Protein Splicing with a Conserved Aspartate

(2011) Zhenming Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications

(2011) Brian P Callahan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of C-terminal intein cleavage in protein splicing from QM/MM molecular dynamics simulations

(2011) Jon I. Mujika et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Arthrobacter Species FB24 Arth_1007 (DnaB) Intein Is a Pseudogene

(2011) Kazuo Tori et al.   PLoS One

Mechanism of protein splicing of the Pyrococcus abyssi lon protease intein

(2010) Kevin M. O’Brien et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Binding and Inhibition of Copper Ions to RecA Inteins fromMycobacterium tuberculosis

(2010) Liyun Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Spontaneous Proton Transfer to a Conserved Intein Residue Determines On-Pathway Protein Splicing

(2010) Brian Pereira et al.   JOURNAL OF MOLECULAR BIOLOGY

Branched intermediate formation stimulates peptide bond cleavage in protein splicing

(2010) Silvia Frutos et al.   Nature Chemical Biology

The Deinococcus radiodurans Snf2 intein caught in the act: Detection of the Class 3 intein signature Block F branched intermediate

(2010) Lear E. Brace et al.   PROTEIN SCIENCE

Split Inteins as Versatile Tools for Protein Semisynthesis

(2009) Henning D. Mootz   CHEMBIOCHEM

The naturally splitNpuDnaE intein exhibits an extraordinarily high rate in the proteintrans-splicing reaction

(2009) Joachim Zettler et al.   FEBS LETTERS

Splicing of the Mycobacteriophage Bethlehem DnaB Intein

(2009) Kazuo Tori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling Protein Splicing: Reaction Pathway for C-Terminal Splice and Intein Scission

(2009) Jon I. Mujika et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Highly Conserved Histidine Plays a Dual Catalytic Role in Protein Splicing: A pKaShift Mechanism

(2009) Zhenming Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of intein activity by its neighboring extein substrates

(2009) G. Amitai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimization of a eukaryotic mini-intein

(2007) Skander Elleuche et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS