Structural and Dynamical Features of Inteins and Implications on Protein Splicing

Structural basis for proteintrans-splicing by a bacterial intein-like domain - protein ligation without nucleophilic side chains

(2013) A. Sesilja Aranko et al.   FEBS Journal

Faster Protein Splicing with theNostoc punctiformeDnaE Intein Using Non-native Extein Residues

(2013) Manoj Cheriyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extein Residues Play an Intimate Role in the Rate-Limiting Step of Protein Trans-Splicing

(2013) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Naturally Split Inteins Assemble through a “Capture and Collapse” Mechanism

(2013) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular domain swapping induces intein-mediated protein alternative splicing

(2013) A Sesilja Aranko et al.   Nature Chemical Biology

A conserved threonine spring-loads precursor for intein splicing

(2013) Albert K. Dearden et al.   PROTEIN SCIENCE

The Thermococcus kodakaraensis Tko CDC21-1 Intein Activates Its N-Terminal Splice Junction in the Absence of a Conserved Histidine by a Compensatory Mechanism

(2012) Kazuo Tori et al.   BIOCHEMISTRY

Mutual synergistic protein folding in split intein

(2012) Yuchuan Zheng et al.   BIOSCIENCE REPORTS

Recent progress in intein research: from mechanism to directed evolution and applications

(2012) Gerrit Volkmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NMR and Crystal Structures of the Pyrococcus horikoshii RadA Intein Guide a Strategy for Engineering a Highly Efficient and Promiscuous Intein

(2012) Jesper S. Oeemig et al.   JOURNAL OF MOLECULAR BIOLOGY

Ultrafast Protein Splicing is Common among Cyanobacterial Split Inteins: Implications for Protein Engineering

(2012) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Control of One-Pot Trans-Splicing Reactions by Using a Wild-Type and Designed Split Intein

(2011) Neel H. Shah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing Intein-Catalyzed Thioester Formation by Unnatural Amino Acid Substitutions in the Active Site

(2011) Dirk Schwarzer et al.   BIOCHEMISTRY

Electronic Structure of Neighboring Extein Residue Modulates Intein C-Terminal Cleavage Activity

(2011) Philip T. Shemella et al.   BIOPHYSICAL JOURNAL

Mechanisms and principles of N-linked protein glycosylation

(2011) Flavio Schwarz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Highly Efficient and More Generalcis- andtrans-Splicing Inteins through Sequential Directed Evolution

(2011) Julia H. Appleby-Tagoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

pKaCoupling at the Intein Active Site: Implications for the Coordination Mechanism of Protein Splicing with a Conserved Aspartate

(2011) Zhenming Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications

(2011) Brian P Callahan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Backbone Dynamics and Global Effects of an Activating Mutation in Minimized Mtu RecA Inteins

(2010) Zhenming Du et al.   JOURNAL OF MOLECULAR BIOLOGY

Spontaneous Proton Transfer to a Conserved Intein Residue Determines On-Pathway Protein Splicing

(2010) Brian Pereira et al.   JOURNAL OF MOLECULAR BIOLOGY

Branched intermediate formation stimulates peptide bond cleavage in protein splicing

(2010) Silvia Frutos et al.   Nature Chemical Biology

Solution structure of DnaE intein fromNostoc punctiforme: Structural basis for the design of a new split intein suitable for site-specific chemical modification

(2009) Jesper S. Oeemig et al.   FEBS LETTERS

Splicing of the Mycobacteriophage Bethlehem DnaB Intein

(2009) Kazuo Tori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selection and Structure of Hyperactive Inteins: Peripheral Changes Relayed to the Catalytic Center

(2009) Kaori Hiraga et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzymatic transition states and dynamic motion in barrier crossing

(2009) Steven D Schwartz et al.   Nature Chemical Biology

Traceless protein splicing utilizing evolved split inteins

(2009) S. W. Lockless et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA