High Throughput Screen Identifies Small Molecule Inhibitors Specific forMycobacterium tuberculosisPhosphoserine Phosphatase

Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones

(2013) Yashang Lee et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of Novel Acetohydroxyacid Synthase Inhibitors as Active Agents against Mycobacterium tuberculosis by Virtual Screening and Bioassay

(2013) Di Wang et al.   Journal of Chemical Information and Modeling

Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases

(2013) Chandan Kishor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis

(2013) Ömer Poyraz et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Serine Phosphatase SerB of Porphyromonas gingivalis Suppresses IL-8 Production by Dephosphorylation of NF-κB RelA/p65

(2013) Hiroki Takeuchi et al.   PLoS Pathogens

Resistance in tuberculosis: what do we know and where can we go?

(2013) Keith D. Green et al.   Frontiers in Microbiology

Structure of phosphoserine aminotransferase fromMycobacterium tuberculosis

(2012) Fasseli Coulibaly et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis

(2012) Suk-Kyeong Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

Human HAD phosphatases: structure, mechanism, and roles in health and disease

(2012) Annegrit Seifried et al.   FEBS Journal

Discovery and Analysis of Cofactor-dependent Phosphoglycerate Mutase Homologs as Novel Phosphoserine Phosphatases inHydrogenobacter thermophilus

(2012) Yoko Chiba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porphyromonas gingivalis SerB-mediated dephosphorylation of host cell cofilin modulates invasion efficiency

(2011) Catherine E. Moffatt et al.   CELLULAR MICROBIOLOGY

Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice

(2011) D. Awasthy et al.   MICROBIOLOGY-SGM

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant

(2011) Guangchun Bai et al.   MOLECULAR MICROBIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis

(2011) Karen G. Anthony et al.   PLoS One

Computer-Aided Identification ofTrypanosoma bruceiUridine Diphosphate Galactose 4′-Epimerase Inhibitors: Toward the Development of Novel Therapies for African Sleeping Sickness

(2010) Jacob D. Durrant et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Population Dynamics and Control of Tuberculosis

(2010) C. Dye et al.   SCIENCE

Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class

(2008) C. Anderle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis

(2008) Hongbo Shen et al.   FEBS Journal

Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival

(2008) Yoshio Hirabayashi et al.   PROGRESS IN LIPID RESEARCH