Disassembly of Lys11and Mixed Linkage Polyubiquitin Conjugates Provides Insights into Function of Proteasomal Deubiquitinases Rpn11 and Ubp6

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

(2014) Matthew Locke et al.   BIOCHEMICAL JOURNAL

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Paradigms of protein degradation by the proteasome

(2014) Tomonao Inobe et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal structure of the human COP9 signalosome

(2014) Gondichatnahalli M. Lingaraju et al.   NATURE

Extended ubiquitin species are protein-based DUB inhibitors

(2014) Daria Krutauz et al.   Nature Chemical Biology

Regulated protein turnover: snapshots of the proteasome in action

(2014) Sucharita Bhattacharyya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Rpn11–Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation

(2014) Evan J Worden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

(2014) G. R. Pathare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

(2014) Ningning Liu et al.   Scientific Reports

Regulation of proteolysis by human deubiquitinating enzymes

(2013) Ziad M. Eletr et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of β-Catenin

(2013) Ning Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs

(2013) Andreas Peth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Binding by a CUE Domain Regulates Ubiquitin Chain Formation by ERAD E3 Ligases

(2013) Katrin Bagola et al.   MOLECULAR CELL

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mixed-Linkage Ubiquitin Chains Send Mixed Messages

(2013) Mark A. Nakasone et al.   STRUCTURE

Unique Structural, Dynamical, and Functional Properties of K11-Linked Polyubiquitin Chains

(2013) Carlos A. Castañeda et al.   STRUCTURE

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

(2013) H Jung et al.   Oncogenesis

Proteomic Identification and Analysis of K63-Linked Ubiquitin Conjugates

(2012) Joe Cannon et al.   ANALYTICAL CHEMISTRY

The Lysine48-Based Polyubiquitin Chain Proteasomal Signal: Not a Single Child Anymore

(2012) Yelena Kravtsova-Ivantsiv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The proteasome: molecular machinery and pathophysiological roles

(2012) Keiji Tanaka et al.   BIOLOGICAL CHEMISTRY

A Universal Expression Tag for Structural and Functional Studies of Proteins

(2012) Vladimir V. Rogov et al.   CHEMBIOCHEM

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

(2012) Laura R Butler et al.   EMBO JOURNAL

Proteasome deubiquitinases as novel targets for cancer therapy

(2012) Pádraig D’Arcy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rpn1 and Rpn2 Coordinate Ubiquitin Processing Factors at Proteasome

(2012) Rina Rosenzweig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of proteasome inhibitors as research tools and cancer drugs

(2012) Alfred L. Goldberg   JOURNAL OF CELL BIOLOGY

Molecular Model of the Human 26S Proteasome

(2012) Paula C.A. da Fonseca et al.   MOLECULAR CELL

The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation

(2012) Nitzan Shabek et al.   MOLECULAR CELL

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

(2012) K. Lasker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near-atomic resolution structural model of the yeast 26S proteasome

(2012) F. Beck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication

(2012) Dilip K. Nag et al.   VIRUS RESEARCH

A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins

(2011) Christopher E. Berndsen et al.   ANALYTICAL BIOCHEMISTRY

Protein-linked Ubiquitin Chain Structure Restricts Activity of Deubiquitinating Enzymes

(2011) Jonathan B. Schaefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease

(2011) Eric B. Dammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Perturbed Ubiquitin Landscape Distinguishes Between Ubiquitin in Trafficking and in Proteolysis

(2011) Inbal Ziv et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

K11-linked ubiquitin chains as novel regulators of cell division

(2011) Katherine E. Wickliffe et al.   TRENDS IN CELL BIOLOGY

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity

(2010) Abhishek Chandra et al.   CURRENT GENETICS

Biochemical and Structural Studies of a HECT-like Ubiquitin Ligase fromEscherichia coliO157:H7

(2010) David Yin-wei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of JAMM Domain Deubiquitinating Enzyme Activity within the RAP80 Complex

(2010) Jeffrey Patterson-Fortin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lys63-specific Deubiquitinating Enzyme BRCC36 Is Regulated by Two Scaffold Proteins Localizing in Different Subcellular Compartments

(2010) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

(2010) Min Jae Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

ATP-Dependent Steps in the Binding of Ubiquitin Conjugates to the 26S Proteasome that Commit to Degradation

(2010) Andreas Peth et al.   MOLECULAR CELL

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains

(2009) Hyoung Tae Kim et al.   EMBO JOURNAL

Specificity of the BRISC Deubiquitinating Enzyme Is Not Due to Selective Binding to Lys63-linked Polyubiquitin

(2009) Eric M. Cooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lysine 48 and Lysine 63 Ubiquitin Conjugates Are Processed Differently by the 26 S Proteasome

(2009) Andrew D. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure and Conformation of Lys63-Linked Tetraubiquitin

(2009) Ajit B. Datta et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquitinated Proteins Activate the Proteasome by Binding to Usp14/Ubp6, which Causes 20S Gate Opening

(2009) Andreas Peth et al.   MOLECULAR CELL

Targeting proteins for degradation

(2009) Erin K Schrader et al.   Nature Chemical Biology

Ubiquitin linkages make a difference

(2009) Ivan Dikic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation

(2009) S. Qin et al.   NUCLEIC ACIDS RESEARCH

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

Dissection of the Carboxyl-Terminal Domain of the Proteasomal Subunit Rpn11 in Maintenance of Mitochondrial Structure and Function

(2008) Teresa Rinaldi et al.   MOLECULAR BIOLOGY OF THE CELL

Extraproteasomal Rpn10 Restricts Access of the Polyubiquitin-Binding Protein Dsk2 to Proteasome

(2008) Yulia Matiuhin et al.   MOLECULAR CELL

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

(2008) Yusuke Sato et al.   NATURE

Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome

(2007) Elena Koulich et al.   MOLECULAR BIOLOGY OF THE CELL