The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks

(2012) Adva Levy-Barda et al.   CELL CYCLE

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates

(2012) Xin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

(2012) Samuel F. Bunting et al.   MOLECULAR CELL

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

(2012) Lin Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development

(2012) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin

(2012) F. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

(2011) Rinske Drost et al.   CANCER CELL

Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP80

(2011) Carmit Strauss et al.   CELL CYCLE

MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner

(2011) Carmit Strauss et al.   DNA REPAIR

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses

(2011) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SKP1-Cul1-F-box and Leucine-rich Repeat Protein 4 (SCF-FbxL4) Ubiquitin Ligase Regulates Lysine Demethylase 4A (KDM4A)/Jumonji Domain-containing 2A (JMJD2A) Protein

(2011) Capucine Van Rechem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation

(2011) M.-K. M. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1

(2011) Anne Bothmer et al.   MOLECULAR CELL

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

(2011) Mayura Meerang et al.   NATURE CELL BIOLOGY

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unraveling the mechanism of BRCA2 in homologous recombination

(2011) William K Holloman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation

(2011) Gabriel Tsz-Mei Lok et al.   NUCLEIC ACIDS RESEARCH

Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression

(2011) Lydia Miller et al.   PHYSIOLOGY & BEHAVIOR

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

Differential Regulation of JAMM Domain Deubiquitinating Enzyme Activity within the RAP80 Complex

(2010) Jeffrey Patterson-Fortin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

(2010) Anne Bothmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair

(2010) Shay Ben-Aroya et al.   PLoS Genetics

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

53BP1: function and mechanisms of focal recruitment

(2009) Jennifer E. FitzGerald et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Proteasome inhibition during myocardial infarction

(2009) X. Yu et al.   CARDIOVASCULAR RESEARCH

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: Identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci

(2009) Myth T.S. Mok et al.   CELLULAR SIGNALLING

Regulatory ubiquitylation in response to DNA double-strand breaks

(2009) Stephanie Panier et al.   DNA REPAIR

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

(2009) Yusuke Sato et al.   EMBO JOURNAL

Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence

(2009) Ann Byrne et al.   EXPERIMENTAL CELL RESEARCH

MERIT40 facilitates BRCA1 localization and DNA damage repair

(2009) L. Feng et al.   GENES & DEVELOPMENT

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

(2009) B. Wang et al.   GENES & DEVELOPMENT

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

(2009) Simon Bekker-Jensen et al.   NATURE CELL BIOLOGY

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

(2009) G. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disassembly of MDC1 Foci Is Controlled by Ubiquitin-Proteasome-dependent Degradation

(2008) Wei Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genetic Interaction Map of RNA-Processing Factors Reveals Links between Sem1/Dss1-Containing Complexes and mRNA Export and Splicing

(2008) Gwendolyn M. Wilmes et al.   MOLECULAR CELL

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

(2008) Simone Difilippantonio et al.   NATURE

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites

(2008) Elijahu Berkovich et al.   Nature Protocols

Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability

(2008) J. Blickwedehl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

(2008) L. J. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics