Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

(2012) Deuan C. Jones et al.   MOLECULAR MICROBIOLOGY

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

(2012) Colin Adrain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

The GENCODE pseudogene resource

(2012) Baikang Pei et al.   GENOME BIOLOGY

Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development

(2011) Kazuhiro Nishimura et al.   AMINO ACIDS

Developmental regulation of gene expression in the absence of transcriptional control: The case of kinetoplastids

(2011) Susanne Kramer   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Regulation and function of polyamines in African trypanosomes

(2011) Erin Willert et al.   TRENDS IN PARASITOLOGY

Pseudokinases-remnants of evolution or key allosteric regulators?

(2010) Elton Zeqiraj et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Pre-mRNA Splicing Machinery of Trypanosomes: Complex or Simplified?

(2010) Arthur Günzl   EUKARYOTIC CELL

Recurrent Emergence of Catalytically Inactive Ornithine Decarboxylase Homologous Forms That Likely Have Regulatory Function

(2010) Ivaylo P. Ivanov et al.   JOURNAL OF MOLECULAR EVOLUTION

Selection of reference genes for mRNA quantification in Trypanosoma brucei

(2010) Martin Brenndörfer et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

eIF5A Promotes Translation Elongation, Polysome Disassembly and Stress Granule Assembly

(2010) Chi Ho Li et al.   PLoS One

Functional significance of eIF5A and its hypusine modification in eukaryotes

(2009) M. H. Park et al.   AMINO ACIDS

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor

(2009) Chaim Kahana   Essays in Biochemistry

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Identification and Characterization of a Novel Deoxyhypusine Synthase inLeishmania donovani

(2009) Bhavna Chawla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase inTrypanosoma bruceiusing chemical and genetic methods

(2009) Susan Wyllie et al.   MOLECULAR MICROBIOLOGY

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE

A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

(2009) Ivaylo P. Ivanov et al.   NUCLEIC ACIDS RESEARCH

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

(2008) Tracy L. Arakaki et al.   MOLECULAR MICROBIOLOGY

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes

(2008) Natasha Sienkiewicz et al.   MOLECULAR MICROBIOLOGY

Regulated Expression of an Essential Allosteric Activator of Polyamine Biosynthesis in African Trypanosomes

(2008) Erin K. Willert et al.   PLoS Pathogens