The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

(2012) Frauke Christ et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

(2012) Manuel Tsiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

(2012) Jacques J. Kessl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

(2011) Jacques J. Kessl et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

(2009) J. J. Kessl et al.   MOLECULAR PHARMACOLOGY

A novel method for determining the inhibitory potential of anti-HIV drugs

(2009) Lin Shen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

(2008) Christopher J. McKee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

(2008) Lin Shen et al.   NATURE MEDICINE