Article
Multidisciplinary Sciences
David S. Vitale, Patrick Lahni, Lindsey Hornung, Tyler Thompson, Peter R. Farrell, Tom K. Lin, Jaimie D. Nathan, Hector R. Wong, Maisam Abu-El-Haija
Summary: This study investigated the role of MMPs and TIMPs in detecting pediatric patients at risk for developing moderately severe AP or SAP. The results showed that MMP-9 and TIMP-1 levels were significantly higher in patients who developed SAP. A regression model using MMP-9 and TIMP-1 predicted SAP.
Article
Clinical Neurology
Domenico M. Romeo, Giorgia Cordaro, Elisa Macchione, Ilaria Venezia, Claudia Brogna, Eugenio Mercuri, Oliviero Bruni
Summary: The study evaluated the psychometric properties of the SDSC in an Italian population of infants and toddlers. The research identified 6 factors related to sleep disturbances and found the adapted SDSC showed good internal consistency, indicating its potential as an evaluation tool for this age group.
Article
Psychiatry
Xianrui Chen, Ping Xu, Yanhui Chen, Shan Chen, Yonghua Yao, Xiaoxia Lin
Summary: This study aimed to evaluate the reliability and validity of the sleep disturbance scale for children (SDSC) in Chinese infants (aged 6-36 months). The results showed that the SDSC-I is reliable and valid for screening and managing sleep disturbances in infants.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Domenico M. Romeo, Chiara Arpaia, Maria Rosaria Lala, Giorgia Cordaro, Francesca Gallini, Giovanni Vento, Eugenio Mercuri, Antonio Chiaretti
Summary: Sleep disorders are crucial in children's development, impacting their emotions, behavior, and cognition. This study aimed to assess the presence of sleep disorders in very preterm infants at 6-36 months and compare them to term-born infants. The study found that low-risk preterm infants had similar incidences of sleep disorders to their term-born peers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Nutrition & Dietetics
Yvan Vandenplas, Nele De Mulder, Elisabeth De Greef, Koen Huysentruyt
Summary: Balanced feeding during the first 1000 days is crucial, with the role of young-child formula being debated. Plant-based drinks have become popular alternatives if they are nutritionally adapted to toddlers' requirements.
Article
Nutrition & Dietetics
Da Li, Ying Wu, Yuanyuan Zhang, Wei Lin, Jia Fan, Peijing Qi, Huyong Zheng, Jie Yan, Ruidong Zhang
Summary: Early enteral nutrition can reduce the risk of secondary infection and significant weight loss in pediatric leukemia-related pancreatitis, with decreased levels of serum enzymes and albumin.
Review
Pediatrics
John M. Grisham, Andrew H. Tran, Kate Ellery
Summary: Severe hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is less common in pediatric patients compared to adults, but evidence suggests it can be associated with more severe course and complications. Treatment involves inpatient management, dietary modification, and long-term interventions. Evidence-based management guidelines for pediatric patients have not been well established.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Belal Al Droubi, Eyad Altamimi
Summary: This retrospective study analyzed a cohort of children with acute pancreatitis at a tertiary care hospital in Jordan, revealing that serum lipase is a more sensitive diagnostic tool for pancreatitis compared to serum amylase. Anatomical abnormalities were the most common etiology of pancreatitis.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Sripriya Sundararajan, Heike Rabe
Summary: Anemia, especially iron-deficiency anemia, is a significant global public health problem that impacts infants and pregnant women. Implementing interventions such as delayed cord clamping can reduce early infantile anemia and newborn mortality rates effectively.
PEDIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Thies Bartram, Peter Schuette, Anja Moericke, Richard S. Houlston, Eva Ellinghaus, Martin Zimmermann, Anke Bergmann, Britt-Sabina Loescher, Norman Klein, Laura Hinze, Stefanie Junk, Michael Forster, Claus R. Bartram, Rolf Koehler, Andre Franke, Martin Schrappe, Christian P. Kratz, Gunnar Cario, Martin Stanulla
Summary: Genetic variation in the ABCC4 gene was found to be associated with AP during ALL treatment, while no association was observed with the CFTR gene. Replication confirmed the ABCC4 variants but not the CFTR variant. Larger international studies are needed to more conclusively assess the risk of rare clinical phenotypes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Heather T. Keenan, Amy Clark, Rich Holubkov, Linda Ewing-Cobbs
Summary: This study evaluated the development of infants and toddlers with traumatic brain injury (TBI) over a 3-year period compared to those with orthopedic injury (OI). The findings showed that children with severe TBI had limited recovery, while those with mild or moderate TBI performed similarly to those with OI. Early intervention is crucial for children with severe TBI, while routine developmental surveillance is recommended for children with milder injuries.
Article
Pediatrics
Kate Templeton, Jenny Chan Yuen, Caitlin Lenz, Alison R. Mann, Haley S. Friedler, Ramy Yim, Maria Alfieri, Amy J. Starmer, Amit S. Grover
Summary: In the management of pediatric acute pancreatitis, early enteral feeding has been shown to improve outcomes and reduce hospital length of stay. Through interventions such as the development of a clinical care pathway and physician education, the proportion of patients receiving early enteral nutrition increased from 40% to 84%, while hospital length of stay significantly decreased. There was no increase in hospital readmission rates.
Article
Psychology, Multidisciplinary
Verena Buren, Daniel Muellensiefen, Tina C. Roeske, Franziska Dege
Summary: Despite advances in research on musical ability in infants, individual differences in general musicality in infants have received relatively little attention. The lack of a clear definition of musical ability in infants has led to a wide range of test procedures, highlighting the need to assess conceptions of musicality in the general population.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Pediatrics
Chi-Bo Chen, Hsiu-Hao Chang, Shu-Wei Chou, Yung-Li Yang, Meng-Yao Lu, Shiann-Tarng Jou, Huey-Ling Chen, Yen-Hsuan Ni, Dong-Tsamn Lin, Mei-Hwei Chang, Jia-Feng Wu
Summary: l-Asparaginase is an important therapeutic for childhood acute lymphoblastic leukemia, and the accumulated dosage of l-asparaginase is considered as a major risk factor of asparaginase-associated pancreatitis. This study found that the incidence of pancreatitis in childhood ALL patients is more strongly correlated with the dose intensity of l-asparaginase rather than with the cumulative dosage. High peak dose intensity and older age at diagnosis were identified as independent predictive factors for the development of AAP.
PEDIATRIC RESEARCH
(2022)
Review
Medicine, General & Internal
Michael A. Mederos, Howard A. Reber, Mark D. Girgis
Summary: Acute pancreatitis is a significant cause of hospital admissions from gastrointestinal diseases in the United States, with proper management involving risk stratification, fluid and nutritional management. Early aggressive fluid resuscitation and enteral nutrition are associated with better outcomes, but the optimal fluid type and rate are still uncertain.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Nishant Patel, Zachary M. Sellers, Amit Grover, Quin Y. Liu, Asim Maqbool, Veronique D. Morinville, Maisam Abu-El-Haija, Sohail Z. Husain
Summary: This paper reviews the history and indications of endoscopic pancreatic function testing (ePFT) in children, compares various methods, and provides guidance on how to perform ePFT in children based on data from both children and adults. Areas in need of further research related to ePFT in children are also proposed.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Andrew T. Trout, Sudha A. Anupindi, A. Jay Freeman, Jorge Alberto Macias-Flores, J. Andres Martinez, Kalyan R. Parashette, Uzma Shah, Judy H. Squires, Veronique D. Morinville, Sohail Z. Husain, Maisam Abu-El-Haija
Summary: The reported incidence of pediatric pancreatitis is increasing, and noninvasive imaging plays important roles in the diagnosis and management of pancreatitis in children, across acute, acute recurrent, and chronic cases. Research is needed to define the performance and role of noninvasive imaging in pediatric pancreatitis.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Editorial Material
Pediatrics
Andrew T. Trout, Sudha A. Anupindi, Sohail Z. Husain, Veronique D. Morinville, Maisam Abu-El-Haija
PEDIATRIC RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jaimie D. Nathan, Kate Ellery, Keshawadhana Balakrishnan, Heli Bhatt, Armando Ganoza, Sohail Z. Husain, Rakesh Kumar, Veronique D. Morinville, J. Antonio Quiros, Sarah J. Schwarzenberg, Zachary M. Sellers, Aliye Uc, Maisam Abu-El-Haija
Summary: Chronic pancreatitis is rare but impactful in childhood, and surgical management must be tailored to the patient's unique needs, considering the morphology of the disease and presence of genetic risk factors. Total pancreatectomy with islet autotransplantation is the best surgical option for patients with small duct disease.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Chinenye R. Dike, Zachary M. Sellers, Sohail Z. Husain, Christopher E. Forsmark, Maisam Abu-El-Haija
Summary: This article aims to provide guidance on the personnel (both physician and nonphysician) needed to provide care for children with pancreatitis, as well as potential alternatives. Further research is needed to understand the impact of these personnel on children with pancreatitis.
Article
Gastroenterology & Hepatology
Venkata S. Akshintala, Sohail Z. Husain, Todd A. Brenner, Anmol Singh, Vikesh K. Singh, Mouen A. Khashab, Christina J. Sperna Weiland, Erwin J. M. van Geenen, Nikhil Bush, Monique Barakat, Ananta Srivastava, Rakesh Kochhar, Rupjyoti Talukdar, Gajanan Rodge, Clement C. H. Wu, Sundeep Lakhtakia, Saroj K. Sinha, Mahesh K. Goenka, D. Nageshwar Reddy
Summary: The INTRO trial aims to evaluate the role of calcineurin inhibitors in preventing post-ERCP pancreatitis (PEP) and lay the foundation for the clinical optimization of this therapeutic strategy from a pharmacologic and economic standpoint.
Review
Gastroenterology & Hepatology
Monique T. Barakat, Asna Khalid, Mang Yu, Ying Ding, Judy -April Murayi, Thottala Jayaraman, Ronald Poropatich, Venkat Akshintala, Wassem Juakiem, Li Wen, Georgios I. Papachristou, Sohail Z. Husain
Summary: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used for pancreaticobiliary disorders, but it may lead to post-ERCP pancreatitis (PEP). Current research suggests that the calcineurin inhibitor tacrolimus has the potential to prevent PEP. This review summarizes the role of tacrolimus in PEP prophylaxis and explores the advantages of rectal administration.
Review
Gastroenterology & Hepatology
Monique T. Barakat, Maisam Abu-El-Haija, Sohail Z. Husain
Summary: This review challenges the traditional concept of drug-induced pancreatitis as a diagnosis of exclusion, proposing instead a continuum of pancreatic injury termed drug-associated pancreatic injury (DAPI) that can occur concomitantly with other risk factors. The review aims to build a foundation for conceptualizing DAPI, highlight specific drugs associated with DAPI, and provide a framework for future studies.
CURRENT OPINION IN GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingpiao Bao, Xiuli Zhang, Bin Li, Mengya Niu, Zengkai Wu, Pengli Song, Xiaoyu Guo, Sohail Z. Husain, Guoyong Hu, Liang Li, Li Wen
Summary: This study found that AXL and MERTK play important roles in AP, and their antagonists may be a novel and potential early treatment for AP. The level of MERTK in peripheral leukocytes may be a promising biomarker for predicting pancreatic severity in patients with AP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Gastroenterology & Hepatology
Monique T. Barakat, Sohail Z. Husain, Roberto Gugig
Summary: Pancreas Divisum (PD) is a common pancreatic ductal variant that is more frequently observed in pediatric patients with acute recurrent pancreatitis (ARP) compared to the general population. Endoscopic retrograde cholangiopancreatography (ERCP) with minor papillotomy has been shown to be beneficial in relieving symptoms and improving clinical outcomes in these patients.
Editorial Material
Gastroenterology & Hepatology
Bomi Lee, Sohail Z. Husain, Ilya Gukovsky
Article
Gastroenterology & Hepatology
Jianbo Ni, Asna Khalid, Yu-Chu Lin, Monique T. Barakat, Jing Wang, Cheng-Yu Tsai, Pasha Reza Shams Azar, Ying Ding, Judy-April Murayi, Thottala Jayaraman, Ronald Poropatich, Rita Bottino, Li Wen, Georgios I. Papachristou, Gayathri Swaminathan, Mang Yu, Sohail Z. Husain
Summary: This study investigated the therapeutic effects of calcineurin inhibitors (CnIs) on post-ERCP pancreatitis (PEP) and its potential toxicities in a preclinical model. The results showed that intraductal administration of CnIs prevented PEP without causing significant hormonal or systemic toxicities, suggesting its clinical utility.
Article
Cell Biology
Cheng-Yu Tsai, Toshie Saito, Mayur Sarangdhar, Maisam Abu-El-Haija, Li Wen, Bomi Lee, Mang Yu, Den A. Lipata, Murli Manohar, Monique T. Barakat, Kevin Contrepois, Thai Hoa Tran, Yves Theoret, Na Bo, Ying Ding, Kristen Stevenson, Elena J. Ladas, Lewis B. Silverman, Loredana Quadro, Tracy G. Anthony, Anil G. Jegga, Sohail Z. Husain
Summary: A systems approach revealed that vitamin A can reduce the risk of asparaginase-associated pancreatitis (AAP). Lower levels of vitamin A were found in ALL patients who developed pancreatitis. Therefore, vitamin A supplementation should be considered in preventing or treating AAP.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Veronique D. Morinville, Sohail Z. Husain, Fuchenchu Wang, Gretchen A. Cress, Maisam Abu-El-Haija, Ankur Chugh, Elissa Downs, Kate Ellery, Douglas S. Fishman, Alvin Jay Freeman, Cheryl E. Gariepy, Matthew Giefer, Tanja Gonska, Quin Liu, Asim Maqbool, Jacob Mark, Brian Arthur Mcferron, Megha Mehta, Jaimie D. Nathan, Ken Ng, Chee Y. Ooi, Emily Perito, Wenly Ruan, Sarah Jane Schwarzenberg, Zachary M. Sellers, Jose Serrano, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark Lowe, Aliye Uc
Summary: This study aimed to analyze the characteristics, co-risk factors, and reliability of the Naranjo scoring system for drug-associated acute pancreatitis (DAP) in children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). The results showed that medications were involved in 7% of ARP or CP patients in the INSPPIRE-2 cohort, with most patients having other risk factors for pancreatitis. The Naranjo scoring system raised questions about its reliability for DAP.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Meeting Abstract
Oncology
Cheng-Yu Tsai, Toshie Saito, Mayur Sarangdhar, Maisam Abu-El-Haija, Li Wen, Bomi Lee, Murli Manohar, Monique T. Barakat, Kevin Contrepois, Na Bo, Ying Ding, Kristen E. Stevenson, Elena Ladas, Lewis B. Silverman, Loredana Quadro, Tracy G. Anthony, Anil Goud Jegga, Sohail Z. Husain
JOURNAL OF CLINICAL ONCOLOGY
(2022)
