Article
Biochemistry & Molecular Biology
Hsuan-Yeh Pan, Ashley Ladd, Manas R. Biswal, Mallika Valapala
Summary: NFAT proteins in RPE cells are activated by calcineurin, regulating cytokine expression and autophagy pathway. Inhibition of NFAT leads to decreased cytokine activation and impaired autophagy flux in response to nutrient deprivation. These findings suggest that NFAT pathway is crucial in regulating autophagy and inflammation in RPE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Pradoldej Sompol, Jenna L. Gollihue, Susan D. Kraner, Irina A. Artiushin, Ryan A. Cloyd, Emad A. Chishti, Shon A. Koren, Grant K. Nation, Jose F. Abisambra, Orsolya Huzian, Lajos I. Nagy, Miklos Santha, Laszlo Hackler, Laszlo G. Puskas, Christopher M. Norris
Summary: Inhibition of the protein phosphatase calcineurin (CN) can improve pathophysiological and cognitive changes in aging rodents and mice with aging-related Alzheimer's disease (AD)-like pathology. A newly developed neuroprotective hydroxyquinoline derivative (Q134R) that suppresses NFAT signaling, without inhibiting CN activity, shows promising results in improving cognitive performance and potentially increasing longevity in mice. These findings suggest that Q134R could be a valuable drug for treating AD and aging-related disorders.
Article
Biochemistry & Molecular Biology
Meredith J. Giblin, Taylor E. Smith, Garrett Winkler, Hannah A. Pendergrass, Minjae J. Kim, Megan E. Capozzi, Rong Yang, Gary W. McCollum, John S. Penn
Summary: Research indicates that the NFAT inhibitor INCA-6 can reduce the expression of IL-1 beta-induced inflammation in retinal cells and endothelial cells, thereby alleviating retinal inflammation secondary to diabetes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yameng Sun, Yijing Tao, Zhimin Geng, Fenglei Zheng, Ying Wang, Yujia Wang, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang, Fangqi Gong
Summary: Through GWAS and linkage disequilibrium analysis, previous studies have found a significant association between the CaN-NFAT signal pathway and susceptibility to KD. However, the molecular basis of the CaN/NFAT pathway in KD remains poorly understood. In this study, we investigate the role of the Ca2+/CaN/NFAT signaling pathway in macrophages in vitro and in vivo on coronary artery lesions induced by LCWE.
Article
Biochemistry & Molecular Biology
Seon Sook Kim, Nam Kyoung Kim, Su Ryeon Seo
Summary: This study provides the first evidence that Cynanchi atrati (CA) root extract and its phenolic acid constituent, sinapic acid (SA), modulate NF-kappa B signaling pathways to treat atopic dermatitis (AD) by targeting endogenous immune regulators.
Article
Nutrition & Dietetics
Hui Zhou, Chen Xia, Yaqing Yang, Hasitha Kalhari Warusawitharana, Xiaohui Liu, Youying Tu
Summary: Theaflavin-3,3'-digallate (TF3), a compound found in black tea, has been found to have anti-coronary heart disease effect. In this study, TF3 was shown to reduce cell size and fetal gene mRNA level in a heart failure cell model, potentially preventing pathological cardiac hypertrophy. TF3 may be a promising natural compound for the treatment of heart failure.
Article
Multidisciplinary Sciences
Meng Du, Cheng Wang, Liuye Yang, Bing Liu, Zhe Zheng, Liu Yang, Fengxiao Zhang, Jiangtong Peng, Dan Huang, Kai Huang
Summary: Atherosclerosis is characterized by the rupture or erosion of unstable plaques, leading to thrombotic events such as myocardial infarction or stroke. In this study, researchers identified a long noncoding RNA called Noncoding Repressor of NFAT (Nron) as a critical regulator of plaque stability in atherosclerosis. Overexpression of Nron led to the formation of more vulnerable plaques, while knockout of Nron inhibited atherosclerosis development and promoted plaque stability. Mechanistically, Nron bound to and negatively regulated NFATc3, which inhibited the proliferation and promoted the apoptosis of vascular smooth muscle cells. Additionally, Nron increased the production and secretion of VEGFA from these cells, enhancing intra-plaque angiogenesis. Inhibition of Nron may hold potential as a therapeutic strategy for atherosclerosis.
Article
Biochemistry & Molecular Biology
Evdokia Bogdanova, Olga Beresneva, Olga Galkina, Irina Zubina, Galina Ivanova, Marina Parastaeva, Natalia Semenova, Vladimir Dobronravov
Summary: The study found that the Wnt/β-catenin and TRPC6/CaN/NFAT hypertrophic signaling pathways may be involved in myocardial remodeling in the settings of AH and CKD, potentially mediated by the FGF23 and alpha-Klotho axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ilenia Sana, Maria Elena Mantione, Piera Angelillo, Marta Muzio
Summary: In recent years, significant progress has been made in the clinical management of chronic lymphocytic leukemia and other B-cell malignancies by targeting B-cell receptor signaling molecules. However, a proportion of patients remain uncured, leading to efforts in studying new potential targets. NFAT is overexpressed and constitutively activated in CLL, with targeting this molecule impacting on CLL cell viability.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Guan-Yu Wang, Dong Shang, Gui-Xin Zhang, Hui-Yi Song, Nan Jiang, Huan-Huan Liu, Hai-Long Chen
Summary: QYD can protect against intestinal mucosal damage caused by severe acute pancreatitis (SAP) by inhibiting IEC apoptosis and the CaN/NFATc3 pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Plant Sciences
Chang-An Geng, Feng-Yang Chen, Jing-Bin Zheng, Ping Liao, Tian-Ze Li, Xue-Mei Zhang, Xin Chen, Ji-Jun Chen
Summary: The compound RGB from Rhododendron brachypodum inhibits the differentiation of regulatory T cells and enhances anti-tumor immune responses through the calcineurin-NFAT signaling pathway. It suppresses Foxp3 expression and inhibits tumor growth in mouse models. RGB or its analogs may have potential as adjuvant agents for tumor therapy.
Article
Immunology
Kenneth Peuker, Anne Strigli, Daniele V. F. Tauriello, Alexander Hendricks, Witigo von Schonfels, Greta Burmeister, Mario Brosch, Alexander Herrmann, Sandra Krueger, Jessica Nitsche, Lea Juznic, Marc Marius Geissler, Andreas Hiergeist, Andre Gessner, Jakob Wirbel, Ruby Priyadarshini Ponnudurai, Antje Tunger, Rebekka Wehner, Daniel E. Stange, Juergen Weitz, Daniela E. Aust, Gustavo B. Baretton, Marc Schmitz, Christoph Rocken, Jochen Hampe, Sebastian Hinz, Georg Zeller, Triantafyllos Chavakis, Clemens Schafmayer, Eduard Batlle, Sebastian Zeissig
Summary: Bacterial sensing by intestinal tumor cells contributes to tumor growth through the calcineurin-NFAT axis, while its inhibition can activate CD8(+) T cell responses and inhibit colorectal cancer growth. This pathway also controls the expression of B7H3 and B7H4 by tumor cells, which inhibits CD8(+) T cell-dependent anti-tumor immunity.
Article
Gastroenterology & Hepatology
Shi-Ying Cai, Dongke Yu, Carol J. Soroka, Jing Wang, James L. Boyer
Summary: NFAT is essential in regulating cytokine expression in cholestatic liver injury, and inhibiting NFAT activation could potentially alleviate cholestasis-induced liver damage.
JOURNAL OF HEPATOLOGY
(2021)
Article
Immunology
Mukul Prasad, Joanna Brzostek, Namrata Gautam, Renu Balyan, Vasily Rybakin, Nicholas R. J. Gascoigne
Summary: Themis-deficient CD4(+) T cells exhibit poor proliferative responses, reduced cytokine production, and weaker inflammatory potential, suggesting impaired effector functions. This defect is likely caused by inefficient TCR signal transduction leading to defective metabolic reprogramming, as evidenced by the inability to upregulate key metabolic pathways and NFAT translocation upon TCR stimulation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biology
Yang Guo, Ze-Yan Yu, Jianxin Wu, Hutao Gong, Scott Kesteven, Siiri E. Iismaa, Andrea Y. Chan, Sara Holman, Silvia Pinto, Andy Pironet, Charles D. Cox, Robert M. Graham, Rudi Vennekens, Michael P. Feneley, Boris Martinac
Summary: Pathological left ventricular hypertrophy (LVH) is a response to pressure overload and is a major predictor of cardiac mortality. Current treatments focus on removing the pressure overload stimulus but do not completely reverse adverse cardiac remodeling. Selective deletion of transient receptor potential melastatin 4 (TRPM4) channels in mouse cardiomyocytes reduces LVH, suggesting that TRPM4 may be a potential therapeutic target for preventing pathological LVH.
Article
Cell Biology
Maria E. Sabbatini, Yan Bi, Baoan Ji, Stephen A. Ernst, John A. Williams
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2010)
Article
Gastroenterology & Hepatology
Stephen J. Crozier, M. Dolors Sans, Jackie Y. Wang, Stephen I. Lentz, Stephen A. Ernst, John A. Williams
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2010)
Article
Gastroenterology & Hepatology
Maria Dolors Sans, Maria Eugenia Sabbatini, Stephen A. Ernst, Louis G. D'Alecy, Ichiko Nishijima, John A. Williams
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2011)
Article
Gastroenterology & Hepatology
Lili Guo, Maria Dolors Sans, Yanan Hou, Stephen A. Ernst, John A. Williams
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2012)
Article
Gastroenterology & Hepatology
John A. Williams
CURRENT OPINION IN GASTROENTEROLOGY
(2010)
Editorial Material
Gastroenterology & Hepatology
John A. Williams
Article
Biochemistry & Molecular Biology
Kamaldeen A. Muili, Dong Wang, Abrahim I. Orabi, Sheharyar Sarwar, Yuhuan Luo, Tanveer A. Javed, John F. Eisses, Syeda M. Mahmood, Shunqian Jin, Vijay P. Singh, Meena Ananthanaravanan, George Perides, John A. Williams, Jeffery D. Molkentin, Sohail Z. Husain
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Yanan Hou, Xuequn Chen, Tatyana Tolmachova, Stephen A. Ernst, John A. Williams
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Neurosciences
Maria E. Sabbatini, Louis D'Alecy, Stephen I. Lentz, Tong Tang, John A. Williams
JOURNAL OF PHYSIOLOGY-LONDON
(2013)
Article
Biochemical Research Methods
Xuequn Chen, Maria Dolors Sans, John R. Strahler, Alla Karnovsky, Stephen A. Ernst, George Michailidis, Philip C. Andrews, John A. Williams
JOURNAL OF PROTEOME RESEARCH
(2010)
Review
Gastroenterology & Hepatology
John A. Williams
Article
Cell Biology
Grzegorz T. Gurda, Jackie Y. Wang, Lili Guo, Stephen A. Ernst, John A. Williams
PHYSIOLOGICAL GENOMICS
(2012)
Article
Multidisciplinary Sciences
Maria Eugenia Sabbatini, John A. Williams
Review
Biochemical Research Methods
Xuequn Chen, Alla Karnovsky, Maria Dolors Sans, Philip C. Andrews, John A. Williams