A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo

(2009) O. Delelis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

(2009) Fabrice Michel et al.   EMBO JOURNAL

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

(2009) J. J. Kessl et al.   MOLECULAR PHARMACOLOGY

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation

(2009) O. Delelis et al.   NUCLEIC ACIDS RESEARCH

Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors

(2009) Erik Serrao et al.   Retrovirology

TRANSITION METAL BIS(2-BROMOPHENYL)DISULFIDE COMPLEXES

(2009) J. R ANACONA et al.   JOURNAL OF THE CHILEAN CHEMICAL SOCIETY

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Insight into the Integrase-DNA Recognition Mechanism

(2008) Olivier Delelis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro initial attachment of HIV-1 integrase to viral ends: control of the DNA specific interaction by the oligomerization state

(2008) P. Lesbats et al.   NUCLEIC ACIDS RESEARCH

Integrase and integration: biochemical activities of HIV-1 integrase

(2008) Olivier Delelis et al.   Retrovirology

Correlation Between Shiftide Activity and HIV-1 Integrase Inhibition by a Peptide Selected from a Combinatorial Library

(2007) Ayelet Armon-Omer et al.   JOURNAL OF MOLECULAR BIOLOGY