Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length

(2011) Thomas L. Kukar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-Secretase Modulators as Potential Disease Modifying Anti-Alzheimer’s Drugs

(2010) Daniel Oehlrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure

(2010) Stefanie Hahn et al.   JOURNAL OF NEUROCHEMISTRY

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

Amyloid beta 42 peptide (A 42)-lowering compounds directly bind to A  and interfere with amyloid precursor protein (APP) transmembrane dimerization

(2010) L. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the chemical space of γ-secretase modulators

(2010) Heiko Zettl et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

(2010) Kengo Uemura et al.   Nature Communications

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

(2009) Kengo Uemura et al.   PLoS One

Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

(2008) Ann C. McKee et al.   BRAIN RESEARCH

γ-Secretase Modulation and its Promise for Alzheimers Disease: a Rationale for Drug Discovery

(2008) Dirk Beher   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase

(2008) Eva Czirr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE