Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 11, Issue 3, Pages 224-230Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2011.06.003
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Funding
- MRC [G0701918] Funding Source: UKRI
- Medical Research Council [G0701918] Funding Source: researchfish
- Medical Research Council [G0701918] Funding Source: Medline
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Cough is the commonest symptom for which patients seek medical care and yet effective, well-tolerated cough medicines remain a significant unmet clinical need. The development of anti-tussive agents has probably been restricted by a number of factors; our understanding of the specific mechanisms evoking cough in different diseases and how this differs from the role of cough as a protective reflex is limited. Also well-validated tools for the assessment of cough have been lacking. These issues have not encouraged investment by the pharmaceutical industry and there have been no new licensed treatments for cough in more than 50 years. This article will use a mechanism-based approach to discuss the clinical evidence for the anti-tussive activity of currently available agents.
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