The Regulation and Physiology of Mitochondrial Proton Leak

Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice

(2010) Carola W. Meyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart

(2010) Enara Aguirre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Uncoupling protein-1 is not leaky

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Absence of mitochondrial uncoupling protein 1 affects apoptosis in thymocytes, thymocyte/T-cell profile and peripheral T-cell number

(2010) Alison E. Adams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue

(2010) Andrea Dlasková et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Brown Fat and the Myth of Diet-Induced Thermogenesis

(2010) Leslie P. Kozak   Cell Metabolism

The mitochondrial respiratory chain

(2010) Peter R. Rich et al.   Essays in Biochemistry

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria

(2010) Laurence J. Toime et al.   FREE RADICAL BIOLOGY AND MEDICINE

UCP3 Translocates Lipid Hydroperoxide and Mediates Lipid Hydroperoxide-dependent Mitochondrial Uncoupling

(2010) Assunta Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling Protein 1 Decreases Superoxide Production in Brown Adipose Tissue Mitochondria

(2010) Rebecca Oelkrug et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of an intramitochondrial protein by the cytosolic proteasome

(2010) V. Azzu et al.   JOURNAL OF CELL SCIENCE

The architecture of respiratory complex I

(2010) Rouslan G. Efremov et al.   NATURE

Cellular bioenergetics as a target for obesity therapy

(2010) Yu-Hua Tseng et al.   NATURE REVIEWS DRUG DISCOVERY

Uncoupling protein-2 regulates lifespan in mice

(2009) Zane B. Andrews et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rapid turnover of mitochondrial uncoupling protein 3

(2009) Vian Azzu et al.   BIOCHEMICAL JOURNAL

Spare respiratory capacity, oxidative stress and excitotoxicity

(2009) David G. Nicholls   BIOCHEMICAL SOCIETY TRANSACTIONS

UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing

(2009) Frédéric Bouillaud   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis

(2009) David A Hughes et al.   BMC EVOLUTIONARY BIOLOGY

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Persistent Oxidative Stress Due to Absence of Uncoupling Protein 2 Associated with Impaired Pancreatic β-Cell Function

(2009) Jingbo Pi et al.   ENDOCRINOLOGY

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

(2009) Dickon M. Humphrey et al.   EXPERIMENTAL GERONTOLOGY

Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria

(2009) Nadeene Parker et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

The on-off switches of the mitochondrial uncoupling proteins

(2009) Vian Azzu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

The Efficiency of Cellular Energy Transduction and Its Implications for Obesity

(2008) Mary-Ellen Harper et al.   Annual Review of Nutrition

Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria

(2008) Nadeene Parker et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells

(2008) Vian Azzu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

On the role of uncoupling protein-2 in pancreatic beta cells

(2008) Charles Affourtit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Characterization of survival and phenotype throughout the life span in UCP2/UCP3 genetically altered mice

(2008) Roger B. McDonald et al.   EXPERIMENTAL GERONTOLOGY

Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice

(2008) Danny K. Asami et al.   EXPERIMENTAL GERONTOLOGY

Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

(2008) Taku Amo et al.   GENE

Essential Role for Uncoupling Protein-3 in Mitochondrial Adaptation to Fasting but Not in Fatty Acid Oxidation or Fatty Acid Anion Export

(2008) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice

(2008) Fatiha Moukdar et al.   JOURNAL OF LIPID RESEARCH

Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)γ co-activator-1β is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells

(2008) Hannes Oberkofler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists

(2008) Jonathan R. S. Arch   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

UCP2 is highly expressed in pancreatic  -cells and influences secretion and survival

(2008) J. Diao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of transport by mitochondrial carriers based on analysis of symmetry

(2008) A. J. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

(2007) Charles Affourtit et al.   BIOCHEMICAL JOURNAL

Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy

(2007) Alison E. Adams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages

(2007) Tindaro M. Giardina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis

(2007) M. Jastroch et al.   PHYSIOLOGICAL GENOMICS