Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

Amino Acid Residue at Position 79 of Marburg Virus VP40 Confers Interferon Antagonism in Mouse Cells

(2015) Alicia R. Feagins et al.   JOURNAL OF INFECTIOUS DISEASES

ORAL SHEDDING OF MARBURG VIRUS IN EXPERIMENTALLY INFECTED EGYPTIAN FRUIT BATS (ROUSETTUS AEGYPTIACUS)

(2015) Brian R. Amman et al.   JOURNAL OF WILDLIFE DISEASES

Human Ebola virus infection results in substantial immune activation

(2015) Anita K. McElroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

(2014) Wei Xu et al.   Cell Host & Microbe

Functional CD8+ T Cell Responses in Lethal Ebola Virus Infection

(2014) S. B. Bradfute et al.   JOURNAL OF IMMUNOLOGY

Crystal Structure of Marburg Virus VP24

(2014) A. P. P. Zhang et al.   JOURNAL OF VIROLOGY

The VP40 Protein of Marburg Virus Exhibits Impaired Budding and Increased Sensitivity to Human Tetherin following Mouse Adaptation

(2014) A. R. Feagins et al.   JOURNAL OF VIROLOGY

Molecular Basis for Ebolavirus VP35 Suppression of Human Dendritic Cell Maturation

(2014) B. Yen et al.   JOURNAL OF VIROLOGY

Emergence of Zaire Ebola Virus Disease in Guinea

(2014) Sylvain Baize et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

(2014) S. K. Gire et al.   SCIENCE

Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection

(2014) Sven Moller-Tank et al.   VIROLOGY

Deep Sequencing Identifies Noncanonical Editing of Ebola and Marburg Virus RNAs in Infected Cells

(2014) Reed S. Shabman et al.   mBio

Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1

(2014) Audrey Page et al.   Cell Reports

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

(2014) Megan R. Edwards et al.   Cell Reports

Interferon-stimulated genes: roles in viral pathogenesis

(2014) John W Schoggins   Current Opinion in Virology

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

Ebola Virus Exploits a Monocyte Differentiation Program To Promote Its Entry

(2013) O. Martinez et al.   JOURNAL OF VIROLOGY

Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

(2013) S. Bale et al.   JOURNAL OF VIROLOGY

The Lack of Maturation of Ebola Virus-Infected Dendritic Cells Results from the Cooperative Effect of at Least Two Viral Domains

(2013) N. M. Lubaki et al.   JOURNAL OF VIROLOGY

An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication

(2013) Reed S. Shabman et al.   PLoS Pathogens

Anti-Tetherin Activities of HIV-1 Vpu and Ebola Virus Glycoprotein Do Not Involve Removal of Tetherin from Lipid Rafts

(2012) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

Virological and Serological Findings in Rousettus aegyptiacus Experimentally Inoculated with Vero Cells-Adapted Hogan Strain of Marburg Virus

(2012) Janusz T. Paweska et al.   PLoS One

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms

(2012) P. Ramanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus

(2012) Gopi S. Mohan et al.   PLoS Pathogens

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

(2012) Shridhar Bale et al.   PLoS Pathogens

Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection

(2012) Brian R. Amman et al.   PLoS Pathogens

The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

(2012) Adrianna P. P. Zhang et al.   PLoS Pathogens

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells

(2011) Lawrence W Leung et al.   IMMUNOLOGY AND CELL BIOLOGY

Reston ebolavirus in Humans and Animals in the Philippines: A Review

(2011) Mary Elizabeth G. Miranda et al.   JOURNAL OF INFECTIOUS DISEASES

Ebola Virus Enters Host Cells by Macropinocytosis and Clathrin-Mediated Endocytosis

(2011) Paulina Aleksandrowicz et al.   JOURNAL OF INFECTIOUS DISEASES

The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin

(2011) Annika Kühl et al.   JOURNAL OF INFECTIOUS DISEASES

The Ebola Virus VP24 Protein Prevents hnRNP C1/C2 Binding to Karyopherin α1 and Partially Alters its Nuclear Import

(2011) Reed S. Shabman et al.   JOURNAL OF INFECTIOUS DISEASES

VP24 Is a Molecular Determinant of Ebola Virus Virulence in Guinea Pigs

(2011) Mathieu Mateo et al.   JOURNAL OF INFECTIOUS DISEASES

Host Response Dynamics Following Lethal Infection of Rhesus Macaques With Zaire ebolavirus

(2011) Hideki Ebihara et al.   JOURNAL OF INFECTIOUS DISEASES

Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process

(2011) L. L. Lofts et al.   JOURNAL OF VIROLOGY

A New Ebola Virus Nonstructural Glycoprotein Expressed through RNA Editing

(2011) M. Mehedi et al.   JOURNAL OF VIROLOGY

Marburg Virus VP40 Antagonizes Interferon Signaling in a Species-Specific Manner

(2011) C. Valmas et al.   JOURNAL OF VIROLOGY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Ebola Virion Attachment and Entry into Human Macrophages Profoundly Effects Early Cellular Gene Expression

(2011) Victoria Wahl-Jensen et al.   PLoS Neglected Tropical Diseases

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

Discovery of an Ebolavirus-Like Filovirus in Europe

(2011) Ana Negredo et al.   PLoS Pathogens

Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain

(2010) Daisy W. Leung et al.   JOURNAL OF MOLECULAR BIOLOGY

Ebola Virus Glycoprotein Counteracts BST-2/Tetherin Restriction in a Sequence-Independent Manner That Does Not Require Tetherin Surface Removal

(2010) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

(2010) K. C. Prins et al.   JOURNAL OF VIROLOGY

Basic Residues within the Ebolavirus VP35 Protein Are Required for Its Viral Polymerase Cofactor Function

(2010) Kathleen C. Prins et al.   JOURNAL OF VIROLOGY

Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin

(2010) Sheli R. Radoshitzky et al.   JOURNAL OF VIROLOGY

The Tyro3 Receptor Kinase Axl Enhances Macropinocytosis of Zaire Ebolavirus

(2010) C. L. Hunt et al.   JOURNAL OF VIROLOGY

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

(2010) Daisy W Leung et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte Apoptosis

(2010) Nadia Wauquier et al.   PLoS Neglected Tropical Diseases

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus

(2010) Charalampos Valmas et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide

(2009) H. Jin et al.   JOURNAL OF GENERAL VIROLOGY

Mechanisms and Consequences of Ebolavirus-Induced Lymphocyte Apoptosis

(2009) Steven B. Bradfute et al.   JOURNAL OF IMMUNOLOGY

Evasion of Interferon Responses by Ebola and Marburg Viruses

(2009) Christopher F. Basler et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Ebola Virus VP35 Antagonizes PKR Activity through Its C-Terminal Interferon Inhibitory Domain

(2009) M. Schumann et al.   JOURNAL OF VIROLOGY

Development and Characterization of a Mouse Model for Marburg Hemorrhagic Fever

(2009) K. L. Warfield et al.   JOURNAL OF VIROLOGY

Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKK  and TBK-1

(2009) K. C. Prins et al.   JOURNAL OF VIROLOGY

Nitric Oxide Induces Cell Death by Regulating Anti-Apoptotic BCL-2 Family Members

(2009) Colleen M. Snyder et al.   PLoS One

Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression

(2009) C. R. Kimberlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 5 1-Integrin controls ebolavirus entry by regulating endosomal cathepsins

(2009) K. L. Schornberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Ebola VP35 interferon inhibitory domain

(2009) D. W. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein

(2009) Rachel L. Kaletsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIG-I activation inhibits ebolavirus replication

(2009) Christina F. Spiropoulou et al.   VIROLOGY

Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery

(2009) Tsung-Hsien Chang et al.   PLoS Pathogens

Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats

(2009) Jonathan S. Towner et al.   PLoS Pathogens

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression

(2008) Toru Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Adhesion Promotes Ebola Virus Envelope Glycoprotein-Mediated Binding and Infection

(2008) D. Dube et al.   JOURNAL OF VIROLOGY

Inhibition of IRF-3 Activation by VP35 Is Critical for the High Level of Virulence of Ebola Virus

(2008) A. L. Hartman et al.   JOURNAL OF VIROLOGY

Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by Tetherin

(2008) N. Jouvenet et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

(2008) A. Okumura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway

(2008) J. E. Strong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA