Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury

AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

(2012) Mackenzie Hadi et al.   ARCHIVES OF TOXICOLOGY

Mouse Precision-Cut Liver Slices as an ex Vivo Model To Study Idiosyncratic Drug-Induced Liver Injury

(2012) Mackenzie Hadi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice

(2012) Rachel P. L. van Swelm et al.   PLoS One

Acute Acetaminophen Intoxication Leads to Hepatic Iron Loading by Decreased Hepcidin Synthesis

(2012) Rachel P. L. van Swelm et al.   TOXICOLOGICAL SCIENCES

Involvement of immune-related factors in diclofenac-induced acute liver injury in mice

(2012) Azusa Yano et al.   TOXICOLOGY

Evaluation of fibrosis in precision-cut tissue slices

(2012) I. M. Westra et al.   XENOBIOTICA

Serum hepcidin: reference ranges and biochemical correlates in the general population

(2011) T. E. Galesloot et al.   BLOOD

Drug-induced liver injury: a summary of recent advances

(2011) Jonathan G Stine et al.   Expert Opinion on Drug Metabolism & Toxicology

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

(2011) Lisa Fredriksson et al.   HEPATOLOGY

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products

(2011) Hartmut Jaeschke et al.   LIFE SCIENCES

Regucalcin and cell regulation: role as a suppressor protein in signal transduction

(2011) Masayoshi Yamaguchi   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanisms of drug-induced liver injury: from bedside to bench

(2011) Shannan Tujios et al.   Nature Reviews Gastroenterology & Hepatology

Mass Spectrometry Analysis of Hepcidin Peptides in Experimental Mouse Models

(2011) Harold Tjalsma et al.   PLoS One

Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes

(2011) M.G.L. Elferink et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

(2010) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats

(2009) Kusum K. Kharbanda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity

(2009) Mohamed A. Abdelmegeed et al.   BIOCHEMICAL PHARMACOLOGY

Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 Cells

(2009) Setsuko Handa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines

(2008) Daniela Vullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The interplay between nitric oxide and peroxiredoxins

(2008) Kahina Abbas et al.   IMMUNOBIOLOGY

Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc

(2008) J. Anthony Graves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Urinary proteomics: towards biomarker discovery, diagnostics and prognostics

(2008) Visith Thongboonkerd   Molecular BioSystems

d-Dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride

(2008) Mineyoshi Hiyoshi et al.   TOXICOLOGY

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

(2008) M ELFERINK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver

(2008) M. van de Bovenkamp et al.   TOXICOLOGY IN VITRO

The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury

(2007) Maxwell Afari Gyamfi et al.   BIOCHEMICAL PHARMACOLOGY