Speculative strategies for new antibacterials: all roads should not lead to Rome

Arrested Protein Synthesis Increases Persister-Like Cell Formation

(2013) Brian W. Kwan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

First novel anti-tuberculosis drug in 40 years

(2013) Randy Osborne   NATURE BIOTECHNOLOGY

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

TD-1792 versus Vancomycin for Treatment of Complicated Skin and Skin Structure Infections

(2012) Martin E. Stryjewski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivity of TD-1792, a Multivalent Glycopeptide-Cephalosporin Antibiotic, against 377 Strains of Anaerobic Bacteria and 34 Strains of Corynebacterium Species

(2012) Kerin L. Tyrrell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Heme Oxygenase-1 in Polymyxin B-Induced Nephrotoxicity in Rats

(2012) Cassiane Dezoti Fonseca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of Polymyxin B-Induced Nephrotoxicity: Implications for Dosing Regimen Design

(2012) Kamilia Abdelraouf et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure aided design of chimeric antibiotics

(2012) Tomislav Karoli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Epidemic of Klebsiella pneumoniae ST11 Clone Coproducing KPC-2 and 16S rRNA Methylase RmtB in a Chinese University Hospital

(2012) Jun-Jie Li et al.   BMC INFECTIOUS DISEASES

Chromosomal bacterial type II toxin–antitoxin systems

(2012) Mohammad Adnan Syed et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study

(2012) J. M. Paterson et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis

(2012) Matthew B. Nodwell et al.   CHEMBIOCHEM

S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications

(2012) Anna-Winona Struck et al.   CHEMBIOCHEM

The Antibiotic CJ-15,801 Is an Antimetabolite that Hijacks and Then Inhibits CoA Biosynthesis

(2012) Renier van der Westhuyzen et al.   CHEMISTRY & BIOLOGY

Fluoroquinolones and the Risk of Serious Arrhythmia: A Population-Based Study

(2012) F. Lapi et al.   CLINICAL INFECTIOUS DISEASES

High-Dose, Extended-Interval Colistin Administration in Critically Ill Patients: Is This the Right Dosing Strategy? A Preliminary Study

(2012) L. Dalfino et al.   CLINICAL INFECTIOUS DISEASES

Pharmacokinetics and pharmacodynamics of ‘old’ polymyxins: what is new?

(2012) Phillip J. Bergen et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: An update

(2012) Jun-ichi Wachino et al.   DRUG RESISTANCE UPDATES

The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

(2012) Martti Vaara et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

(2012) Qinglin Du et al.   International Journal of Biological Sciences

Risk factors for development of Clostridium difficile infection due to BI/NAP1/027 strain: a meta-analysis

(2012) Konstantinos Z. Vardakas et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The emerging problem of linezolid-resistant Staphylococcus

(2012) B. Gu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2012 and beyond: potential for the start of a second pre-antibiotic era?

(2012) P. C. Appelbaum   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens

(2012) M. Vaara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Design and Synthesis of Potential Mechanism-Based Inhibitors of the Aminotransferase BioA Involved in Biotin Biosynthesis

(2012) Ce Shi et al.   JOURNAL OF ORGANIC CHEMISTRY

YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli

(2012) Hisako Masuda et al.   MOLECULAR MICROBIOLOGY

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

(2012) Xiaoxue Wang et al.   Nature Chemical Biology

Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells

(2012) Marie-Paule Mingeot-Leclercq et al.   PEPTIDES

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

The toxin-antitoxin systemtisB-istR1

(2012) E. Gerhart H. Wagner et al.   RNA Biology

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

New-found fundamentals of bacterial persistence

(2012) Cyrielle I. Kint et al.   TRENDS IN MICROBIOLOGY

Evaluation of CoA biosynthesis proteins of Mycobacterium tuberculosis as potential drug targets

(2012) Anisha Ambady et al.   TUBERCULOSIS

Biotin Analogues with Antibacterial Activity Are Potent Inhibitors of Biotin Protein Ligase

(2012) Tatiana P. Soares da Costa et al.   ACS Medicinal Chemistry Letters

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

Antistaphylococcal Activity of TD-1792, a Multivalent Glycopeptide-Cephalosporin Antibiotic

(2011) Johanne Blais et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Features ofblaNDM-1-Positive Enterobacteriaceae

(2011) Laurent Poirel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against Gram-Positive Bacteria, in a Neutropenic Murine Thigh Model

(2011) Sharath S. Hegde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The antibiotics roseoflavin and 8-demethyl-8-amino-riboflavin from Streptomyces davawensis are metabolized by human flavokinase and human FAD synthetase

(2011) Danielle B. Pedrolli et al.   BIOCHEMICAL PHARMACOLOGY

Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

(2011) Benjamin P. Duckworth et al.   CHEMISTRY & BIOLOGY

Toxins-antitoxins: diversity, evolution and function

(2011) Finbarr Hayes et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dosing of colistin—back to basic PK/PD

(2011) Phillip J Bergen et al.   CURRENT OPINION IN PHARMACOLOGY

Cardiovascular and metabolic safety profiles of the fluoroquinolones

(2011) Alessandra Pugi et al.   Expert Opinion On Drug Safety

The efficacy and safety of antibiotic combination therapy for infections caused by Gram-positive and Gram-negative organisms

(2011) Mao Hagihara et al.   Expert Opinion On Drug Safety

Flavogenomics - a genomic and structural view of flavin-dependent proteins

(2011) Peter Macheroux et al.   FEBS Journal

Toxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

(2011) Julia J. Williams et al.   FEMS MICROBIOLOGY LETTERS

Emergence and spread ofcfr-mediated multiresistance in staphylococci: an interdisciplinary challenge

(2011) Wolfgang Witte et al.   Future Microbiology

Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates

(2011) Jiyong Yang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Nosocomial outbreak of methicillin- and linezolid-resistant Staphylococcus epidermidis associated with catheter-related infections in intensive care unit patients

(2011) Cristina Seral et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Detection of the staphylococcal multiresistance gene cfr in Proteus vulgaris of food animal origin

(2011) Y. Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Complex Lipoate Utilization Pathway inListeria monocytogenes

(2011) Quin H. Christensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling of the structure and interactions of the B. anthracis antitoxin, MoxX: deletion mutant studies highlight its modular structure and repressor function

(2011) Nikita Chopra et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development

(2011) Hannes Mutschler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activity of Polymyxin B and the Novel Polymyxin Analogue CB-182,804 Against Contemporary Gram-Negative Pathogens in New York City

(2011) John Quale et al.   Microbial Drug Resistance

Regulation of growth and death in Escherichia coli by toxin–antitoxin systems

(2011) Yoshihiro Yamaguchi et al.   NATURE REVIEWS MICROBIOLOGY

Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

(2011) Raphaël Leplae et al.   NUCLEIC ACIDS RESEARCH

Identification of Inhibitors against Mycobacterium tuberculosis Thiamin Phosphate Synthase, an Important Target for the Development of Anti-TB Drugs

(2011) Garima Khare et al.   PLoS One

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Riboflavin analog Roseoflavin targets an FMN-riboswitch and blocksListeria monocytogenes growth, but also stimulates virulence gene-expression and infection

(2011) Mikael Mansjö et al.   RNA Biology

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression

(2011) Sae Woong Park et al.   PLoS Pathogens

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: Novel antibacterial agents against Mycobacterium tuberculosis

(2010) Xiaokai Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus

(2010) Gracia Morales et al.   CLINICAL INFECTIOUS DISEASES

The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020

(2010)   CLINICAL INFECTIOUS DISEASES

Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides

(2010) Y. Zhou et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

(2010) Varvara Pokrovskaya et al.   Expert Opinion on Drug Discovery

RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms

(2010) Jun-Ichi Wachino et al.   FEMS MICROBIOLOGY LETTERS

Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice

(2010) C. Vingsbo Lundberg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates

(2010) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In Vitro Evaluation of Antibiotic Synergy for Polymyxin B-Resistant Carbapenemase-Producing Klebsiella pneumoniae

(2010) A. Elemam et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Lipoic Acid Metabolism in Microbial Pathogens

(2010) M. D. Spalding et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Abundance of type I toxin–antitoxin systems in bacteria: searches for new candidates and discovery of novel families

(2010) Elizabeth M. Fozo et al.   NUCLEIC ACIDS RESEARCH

Characterization of the Interaction and Cross-Regulation of Three Mycobacterium tuberculosis RelBE Modules

(2010) Min Yang et al.   PLoS One

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the structures of several antibiotics bound to the bacterial ribosome

(2010) D. Bulkley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

(2010) V. L. Arcus et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression

(2010) Elaine R. Lee et al.   RNA Biology

Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

(2010) Tobias Dörr et al.   PLOS BIOLOGY

Novel heterodimer antibiotics: a review of recent patent literature

(2009) Daniel D Long et al.   Future Medicinal Chemistry

Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers

(2009) Daniel D Long et al.   JOURNAL OF ANTIBIOTICS

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

(2009) F. E. A. Ali et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics

(2009) Varvara Pokrovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of the Covalent Hydrates of Trifluoromethylated Pyrazoles as Riboflavin Synthase Inhibitors with Antibiotic Activity AgainstMycobacterium tuberculosis

(2009) Yujie Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Scintillation proximity assay for measurement of RNA methylation

(2009) M. R. Baker et al.   NUCLEIC ACIDS RESEARCH

A toxin–antitoxin module as a target for antimicrobial development

(2009) Virginia S. Lioy et al.   PLASMID

Coin hoards speak of population declines in Ancient Rome

(2009) P. Turchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus

(2008) G. T. Robertson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors

(2008) L. K. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

(2008) Xuequan Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chromosomal Toxin-Antitoxin Systems May Act as Antiaddiction Modules

(2008) M. Saavedra De Bast et al.   JOURNAL OF BACTERIOLOGY

Molecular Control of Bacterial Death and Lysis

(2008) K. C. Rice et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli

(2008) Cecilia Unoson et al.   MOLECULAR MICROBIOLOGY

Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA

(2008) Keith Connolly et al.   MOLECULAR MICROBIOLOGY

Virtual Screening and Experimental Verification to Identify Potential Inhibitors of the ErmC Methyltransferase Responsible for Bacterial Resistance against Macrolide Antibiotics

(2007) Marcin Feder et al.   ChemMedChem