Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells

In Vitro Genotoxicity of Fipronil Sister Chromatid Exchange, Cytokinesis Block Micronucleus Test, and Comet Assay

(2014) Ayla Çelik et al.   DNA AND CELL BIOLOGY

Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

(2014) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Performance of Comet and Micronucleus Assays in Metabolic Competent HepaRG Cells to Predict In Vivo Genotoxicity

(2014) Ludovic Le Hégarat et al.   TOXICOLOGICAL SCIENCES

Nicotine, cotinine, and β-nicotyrine inhibit NNK-induced DNA-strand break in the hepatic cell line HepaRG

(2014) Patricia Ordonez et al.   TOXICOLOGY IN VITRO

Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells

(2013) Laure Khoury et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG

(2013) A. Azqueta et al.   MUTAGENESIS

Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells

(2013) Marc Le Vee et al.   TOXICOLOGY IN VITRO

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes

(2013) M.J.A. Jetten et al.   TOXICOLOGY IN VITRO

Genotoxicity of pesticide mixtures present in the diet of the French population

(2012) Vanessa Graillot et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Evidence of the in vitro genotoxicity of methyl-pyrazole pesticides in human cells

(2012) Vanessa Graillot et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons

(2012) M. Audebert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of the γH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines

(2011) Marc Audebert et al.   ARCHIVES OF TOXICOLOGY

An adaptation of the human HepaRG cells to the in vitro micronucleus assay

(2011) R. Josse et al.   MUTAGENESIS

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells

(2011) C. Magkoufopoulou et al.   MUTAGENESIS

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

(2011) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Follow-up actions from positive results of in vitro genetic toxicity testing

(2010) Kerry L. Dearfield et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Accumulation and DNA damage in fathead minnows (Pimephales promelas) exposed to 2 brominated flame-retardant mixtures, Firemaster® 550 and Firemaster® BZ-54

(2010) Jonathan S. Bearr et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays

(2010) L. Le Hegarat et al.   MUTAGENESIS

Identification of toxicological biomarkers of di(2-ethylhexyl) phthalate in proteins secreted by HepG2 cells using proteomic analysis

(2010) Seonyoung Choi et al.   PROTEOMICS

Advantages of Human Hepatocyte-Derived Transformants Expressing a Series of Human Cytochrome P450 Isoforms for Genotoxicity Examination

(2010) Tsuneo Hashizume et al.   TOXICOLOGICAL SCIENCES

Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines

(2010) Julie Dumont et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium

(2010) Pinar Erkekoglu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines

(2010) M. Audebert et al.   TOXICOLOGY LETTERS

Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression

(2009) Claire Legendre et al.   EUROPEAN JOURNAL OF CANCER

Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies

(2008) R. Josse et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

Evolving concepts in liver tissue modeling and implications forin vitrotoxicology

(2008) André Guillouzo et al.   Expert Opinion on Drug Metabolism & Toxicology