Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity

(2010) Terry John Evans et al.   DNA REPAIR

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes

(2010) Danyel G.J. Jennen et al.   DRUG DISCOVERY TODAY

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

(2010) L. Guo et al.   DRUG METABOLISM AND DISPOSITION

Analysis of published data for top concentration considerations in mammalian cell genotoxicity testing

(2010) James M. Parry et al.   MUTAGENESIS

Use of transcriptomics in understanding mechanisms of drug-induced toxicity

(2010) Yuxia Cui et al.   PHARMACOGENOMICS

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis

(2010) Stefan Pfuhler et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1and Survivin Expression through Wnt/β-Catenin Signaling Pathway

(2009) Bao-En Shan et al.   CANCER INVESTIGATION

DNA Structure and Integrity Checkpoints during the Cell Cycle and Their Role in Drug Targeting and Sensitivity of Tumor Cells to Anticancer Treatment

(2009) Andrzej Skladanowski et al.   CHEMICAL REVIEWS

Regulation of Survivin and Bcl-2 in HepG2 Cell Apoptosis Induced by Quercetin

(2009) Jun Tan et al.   CHEMISTRY & BIODIVERSITY

H2AX: functional roles and potential applications

(2009) Jennifer S. Dickey et al.   CHROMOSOMA

Aryl Hydrocarbon Receptor Regulates Cell Cycle Progression in Human Breast Cancer Cells via a Functional Interaction with Cyclin-Dependent Kinase 4

(2009) M. A. Barhoover et al.   MOLECULAR PHARMACOLOGY

Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development

(2009) Walter M.A. Westerink et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

H2AX phosphorylation as a genotoxicity endpoint

(2009) Gary Peter Watters et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development

(2009) Walter M.A. Westerink et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

GADD45a-GFP GreenScreen HC assay results for the ECVAM recommended lists of genotoxic and non-genotoxic chemicals for assessment of new genotoxicity tests

(2009) Louise Birrell et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Interlaboratory and Interplatform Comparison of Microarray Gene Expression Analysis of HepG2 Cells Exposed to Benzo(a)pyrene

(2009) Sarah L. Hockley et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat

(2009) C. Gupta et al.   PHYTOTHERAPY RESEARCH

Discrimination for Genotoxic and Nongenotoxic Carcinogens by Gene Expression Profiling in Primary Mouse Hepatocytes Improves with Exposure Time

(2009) Karen Mathijs et al.   TOXICOLOGICAL SCIENCES

Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis

(2009) Qiang Zhang et al.   TOXICOLOGY IN VITRO

Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes

(2009) Zdeněk Dvořák et al.   TOXICOLOGY IN VITRO

Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells

(2008) Eun Jeong Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Genistein Induction of Human Sulfotransferases in HepG2 and Caco-2 Cells

(2008) Yue Chen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Stabilization of p53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG2 Cells

(2008) Shunsuke TANIGAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology

(2008) Sarah C Shuck et al.   CELL RESEARCH

Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites

(2008) Satoko Iwahori et al.   CELLULAR SIGNALLING

Quercetin: potentials in the prevention and therapy of disease

(2008) Stephan C Bischoff   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis

(2008) Koji Kawata et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

NuGO contributions to GenePattern

(2008) P. J. De Groot et al.   Genes and Nutrition

Catecholestrogens induce oxidative stress and malignant transformation in human endometrial glandular cells: Protective effect of catechol‐O‐methyltransferase

(2008) Salama A. Salama et al.   INTERNATIONAL JOURNAL OF CANCER

ECVAM retrospective validation of in vitro micronucleus test (MNT)

(2008) R. Corvi et al.   MUTAGENESIS

Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay

(2008) Heike K. Winter et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Development of a highthroughput yeast-based assay for detection of metabolically activated genotoxins

(2008) Xuemei Liu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: Evaluation by the comet assay

(2008) A.A. Ramos et al.   TOXICOLOGY LETTERS

Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity

(2008) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGY LETTERS