NSAIDs do not require the presence of a carboxylic acid to exert their anti-inflammatory effect – why do we keep using it?

Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)

(2010) John L Wallace et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: Synthesis, biological evaluation and nitric oxide release studies

(2009) Khaled R.A. Abdellatif et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemopreventive Efficacy of Naproxen and Nitric Oxide-naproxen in Rodent Models of Colon, Urinary Bladder, and Mammary Cancers

(2009) V. E. Steele et al.   Cancer Prevention Research

Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs

(2009) Neville D. Yeomans et al.   CURRENT MEDICAL RESEARCH AND OPINION

Present status and strategy of NSAIDs-induced small bowel injury

(2009) Kazuhide Higuchi et al.   JOURNAL OF GASTROENTEROLOGY

Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself?

(2008) John L. Wallace   PHYSIOLOGICAL REVIEWS

Design, Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenicity studies of Novel S-Substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of Diclofenac acid as Nonulcerogenic Derivatives

(2007) Shashikant V. Bhandari et al.   BIOORGANIC & MEDICINAL CHEMISTRY