Gambogic acid induces apoptosis and inhibits colorectal tumor growthviamitochondrial pathways

Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1, p62 and NBR1) in human bladder cancer cells

(2014) Mohammad Ishaq et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells

(2014) Lamya M Saeed et al.   JOURNAL OF APPLIED TOXICOLOGY

Gambogic acid induces growth inhibition and differentiation via upregulation of p21waf1/cip1 expression in acute myeloid leukemia cells

(2014) Yan Chen et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Blockade of Fas Signaling in Breast Cancer Cells Suppresses Tumor Growth and Metastasis via Disruption of Fas Signaling-initiated Cancer-related Inflammation

(2014) Qiuyan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells

(2014) Qi Qi et al.   MOLECULAR CARCINOGENESIS

ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

(2014) Haiyuan Zhang et al.   PLoS One

Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling

(2013) L-H Wang et al.   BRITISH JOURNAL OF CANCER

Cytotoxic effect of gambogic acid on SH-SY5Y neuroblastoma cells is mediated by intrinsic caspase-dependent signaling pathway

(2013) Md. Ataur Rahman et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Viability inhibition effect of gambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway

(2013) Wei Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Antiproliferative activity of gambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells

(2013) PARRY NGAN HON LEE et al.   ONCOLOGY REPORTS

Silencing of Pokemon Enhances Caspase-Dependent Apoptosis via Fas- and Mitochondria-Mediated Pathways in Hepatocellular Carcinoma Cells

(2013) Yu-Qin Zhang et al.   PLoS One

Epstein-Barr Virus_Encoded LMP1 Upregulates MicroRNA-21 to Promote the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin-Induced Apoptosis by Suppressing PDCD4 and Fas-L

(2013) Guang-Da Yang et al.   PLoS One

The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells

(2012) Hiu-Yee Kwan et al.   JOURNAL OF GASTROENTEROLOGY

Studies on chemical modification and biology of a natural product, gambogic acid (III): Determination of the essential pharmacophore for biological activity

(2011) Xiaojian Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles

(2011) Baoan Chen et al.   International Journal of Nanomedicine

Effects of α-mangostin on apoptosis induction of human colon cancer

(2011) Ramida Watanapokasin   WORLD JOURNAL OF GASTROENTEROLOGY

Steroid Receptor Coactivator-3 Expression in Lung Cancer and Its Role in the Regulation of Cancer Cell Survival and Proliferation

(2010) D. Cai et al.   CANCER RESEARCH

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

(2009) Di He et al.   BMC CANCER

Gambogic acid down-regulates MDM2 oncogene and induces p21Waf1/CIP1 expression independent of p53

(2009) Jing-Jing Rong et al.   CANCER LETTERS

Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells

(2009) Hongyan Gu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells

(2009) Feifei Nie et al.   TOXICOLOGY

Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells

(2009) Rui Li et al.   TOXICOLOGY

Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

(2009) Fatima Haggar et al.   Clinics in Colon and Rectal Surgery

Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis

(2008) Hyo-Jung Lee et al.   CANCER LETTERS

Targeting the extrinsic apoptosis pathway in cancer

(2008) Avi Ashkenazi   CYTOKINE & GROWTH FACTOR REVIEWS

Inhibition of α4 integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with Gambogic acid

(2008) Jie Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis

(2008) Qi Qi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma

(2008) Jun Wang et al.   TOXICOLOGY

Inhibition of glioblastoma growth and angiogenesis by gambogic acid: An in vitro and in vivo study

(2007) Lei Qiang et al.   BIOCHEMICAL PHARMACOLOGY