Development of Bioorthogonal Reactions and Their Applications in Bioconjugation

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Alkene-Tetrazine Ligation for Imaging Cellular DNA

(2014) Ulrike Rieder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

“Photoclick” Postsynthetic Modification of DNA

(2014) Stefanie Arndt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing the Anticancer Mechanism of (−)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation

(2014) Chao Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

“Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates

(2014) Wen Tang et al.   CHEMICAL SOCIETY REVIEWS

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

(2014) Craig S. McKay et al.   CHEMISTRY & BIOLOGY

“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling

(2014) Zhengqiu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycan Imaging in Intact Rat Hearts and Glycoproteomic Analysis Reveal the Upregulation of Sialylation during Cardiac Hypertrophy

(2014) Jie Rong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

(2014) Jie Li et al.   Nature Chemical Biology

Design strategies for bioorthogonal smart probes

(2014) Peyton Shieh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli

(2014) Maiyun Yang et al.   Nature Communications

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

(2013) Zhengqiu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening

(2013) Sergii Kolodych et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus

(2013) Shixian Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells

(2013) Peng An et al.   CHEMICAL COMMUNICATIONS

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Cell-selective metabolic labeling of biomolecules with bioorthogonal functionalities

(2013) Ran Xie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fluorogenic, Two-Photon-Triggered Photoclick Chemistry in Live Mammalian Cells

(2013) Zhipeng Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Free Palladium-Mediated Site-Specific Protein Labeling Inside Gram-Negative Bacterial Pathogens

(2013) Jie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Bioorthogonal Ligation Enabled by Click Cycloaddition of o-Quinolinone Quinone Methide and Vinyl Thioether

(2013) Qiang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

(2013) Marjoke F. Debets et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells

(2012) Zhipeng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

(2012) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetically Encoded Tetrazine Amino Acid Directs Rapid Site-Specific in Vivo Bioorthogonal Ligation with trans-Cyclooctenes

(2012) Jason L. Seitchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes

(2012) Ran Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

(2012) Kathrin Lang et al.   Nature Chemistry

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

5-Ethynyl-2′-deoxycytidine as a new agent for DNA labeling: Detection of proliferating cells

(2011) Dezhong Qu et al.   ANALYTICAL BIOCHEMISTRY

A Bioorthogonal Quadricyclane Ligation

(2011) Ellen M. Sletten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid, Photoactivatable Turn-On Fluorescent Probes Based on an Intramolecular Photoclick Reaction

(2011) Zhipeng Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Free Sonogashira Cross-Coupling for Functionalization of Alkyne-Encoded Proteins in Aqueous Medium and in Bacterial Cells

(2011) Nan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Incorporation of Photo-Cross-Linker and Bioorthogonal Amino Acids into Enteric Bacterial Pathogens

(2011) Shixian Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides

(2011) A. B. Neef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Modification by Strain-Promoted Alkyne-Nitrone Cycloaddition

(2010) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

(2010) Jan Dommerholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells

(2010) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

A Biosynthetic Route to Photoclick Chemistry on Proteins

(2010) Jiangyun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Chemical Reporters for Monitoring Protein Acetylation

(2010) Yu-Ying Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Visualization and Large-Scale Profiling of Bacterial Lipoproteins with Chemical Reporters

(2010) Kavita J. Rangan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Probes That Target Functional Subclasses of Phospholipases in Proteomes

(2010) Sarah E. Tully et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors

(2010) Pamela V. Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Progression from a stem cell-like state to early differentiation in the C. elegans germ line

(2010) O. Cinquin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast Alkene Functionalization In Vivo by Photoclick Chemistry: HOMO Lifting of Nitrile Imine Dipoles

(2009) Yizhong Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Fluorescence Labeling of Lipids in Living Cells

(2009) Anne B. Neef et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Photocrosslinking and Click Chemistry Enable the Specific Detection of Proteins Interacting with Phospholipids at the Membrane Interface

(2009) Jacob Gubbens et al.   CHEMISTRY & BIOLOGY

Advances in Bioconjugation

(2009) Jeet Kalia et al.   CURRENT ORGANIC CHEMISTRY

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic labeling and direct imaging of choline phospholipids in vivo

(2009) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Photoinducible 1,3-Dipolar Cycloaddition Reaction for Rapid, Selective Modification of Tetrazole-Containing Proteins

(2008) Wenjiao Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Selective Functionalization of a Genetically Encoded Alkene-Containing Protein via “Photoclick Chemistry” in Bacterial Cells

(2008) Wenjiao Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

(2008) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging the glycome

(2008) S. T. Laughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE