Design strategies for bioorthogonal smart probes

Bioorthogonal Reactions for Labeling Proteins

(2014) Kathrin Lang et al.   ACS Chemical Biology

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging

(2014) Labros G. Meimetis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Chelating Azides for Efficient Click Conjugation Reactions in Complex Media

(2014) Valentina Bevilacqua et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ Synthesis of Alkenyl Tetrazines for Highly Fluorogenic Bioorthogonal Live-Cell Imaging Probes

(2014) Haoxing Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts

(2014) András Herner et al.   BIOCONJUGATE CHEMISTRY

A genetically encoded aldehyde for rapid protein labelling

(2014) Alfred Tuley et al.   CHEMICAL COMMUNICATIONS

A highly efficient oxidative condensation reaction for selective protein conjugation

(2014) Ao Ji et al.   CHEMICAL COMMUNICATIONS

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

Rapid, Hydrolytically Stable Modification of Aldehyde-Terminated Proteins and Phage Libraries

(2014) Pavel I. Kitov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation

(2014) Jiun-Jie Shie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of Spiro[2.3]hex-1-ene, a Genetically Encodable Double-Strained Alkene for Superfast Photoclick Chemistry

(2014) Zhipeng Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amplification by nucleic acid-templated reactions

(2014) Julia Michaelis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rigid tetrazine fluorophore conjugates with fluorogenic properties in the inverse electron demand Diels–Alder reaction

(2014) Achim Wieczorek et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes

(2014) P. Shieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switchable fluorescence by click reaction of a novel azidocarbazole dye

(2014) Anna Hörner et al.   RSC Advances

A Genetically Encoded Acrylamide Functionality

(2013) Yan-Jiun Lee et al.   ACS Chemical Biology

BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes

(2013) Jonathan C. T. Carlson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Imaging Cell Surface Glycosylation in Vivo Using “Double Click” Chemistry

(2013) André A. Neves et al.   BIOCONJUGATE CHEMISTRY

Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

(2013) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Template-Directed Fluorogenic Oligonucleotide Ligation Using “Click” Chemistry: Detection of Single Nucleotide Polymorphism in the Human p53 Tumor Suppressor Gene

(2013) Huabing Sun et al.   BIOCONJUGATE CHEMISTRY

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

A coumarin derivative as a fluorogenic glycoproteomic probe for biological imaging

(2013) Lei Rong et al.   CHEMICAL COMMUNICATIONS

The nitrilimine–alkene cycloaddition is an ultra rapid click reaction

(2013) Xiaoshan Shayna Wang et al.   CHEMICAL COMMUNICATIONS

Water-Soluble Organocatalysts for Hydrazone and Oxime Formation

(2013) Pete Crisalli et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorogenic, Two-Photon-Triggered Photoclick Chemistry in Live Mammalian Cells

(2013) Zhipeng Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid oligonucleotide-templated fluorogenic tetrazine ligations

(2013) Jolita Šečkutė et al.   NUCLEIC ACIDS RESEARCH

A new family of bioorthogonally applicable fluorogenic labels

(2013) András Herner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

(2013) Marjoke F. Debets et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design and Synthesis of Laser-Activatable Tetrazoles for a Fast and Fluorogenic Red-Emitting 1,3-Dipolar Cycloaddition Reaction

(2013) Peng An et al.   ORGANIC LETTERS

MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes

(2013) Jun Cheng Er et al.   Chemical Science

Biomolecular patterning of glass surfaces via strain-promoted cycloaddition of azides and cyclooctynes

(2013) M. A. Wijdeven et al.   RSC Advances

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiacycloalkynes for Copper-Free Click Chemistry

(2012) Gabriela de Almeida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Imaging of Aurora Kinase A in Live Cells

(2012) Katherine S. Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells

(2012) Zhipeng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

(2012) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction

(2012) Emine Kaya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Cellular Sialic Acid Content Using Nitrobenzoxadiazole Carbonyl-Reactive Chromophores

(2012) Jessie A. Key et al.   BIOCONJUGATE CHEMISTRY

Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide–Alkyne Cycloaddition

(2012) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Genetically Encoded Tetrazine Amino Acid Directs Rapid Site-Specific in Vivo Bioorthogonal Ligation with trans-Cyclooctenes

(2012) Jason L. Seitchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Fluorogenic Probe for the Catalyst-Free Detection of Azide-Tagged Molecules

(2012) Frédéric Friscourt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorogenic Azidofluoresceins for Biological Imaging

(2012) Peyton Shieh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

(2012) Kathrin Lang et al.   Nature Chemistry

A Pictet-Spengler ligation for protein chemical modification

(2012) P. Agarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Group 14 Rhodamines as Platforms for Near-Infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer

(2011) Yuichiro Koide et al.   ACS Chemical Biology

Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

(2011) Christen Besanceney-Webler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developing Visible Fluorogenic ‘Click-On’ Dyes for Cellular Imaging

(2011) Jianjun Qi et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation

(2011) Mark R. Karver et al.   BIOCONJUGATE CHEMISTRY

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

(2011) Weixuan Chen et al.   CHEMICAL COMMUNICATIONS

Installation/Modulation of the Emission Response via Click Reaction

(2011) Subhendu Sekhar Bag et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid, Photoactivatable Turn-On Fluorescent Probes Based on an Intramolecular Photoclick Reaction

(2011) Zhipeng Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycoprotein Labeling Using Engineered Variants of Galactose Oxidase Obtained by Directed Evolution

(2011) Julie B. Rannes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine–trans-Cyclooctene Ligation

(2011) Michael T. Taylor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels–Alder Cycloaddition for Fluorophore Targeting to Specific Proteins inside Living Cells

(2011) Daniel S. Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a Fluorogenic Cyclooctyne Activated by Cu-Free Click Chemistry

(2011) John C. Jewett et al.   ORGANIC LETTERS

Tuning the optical properties of BODIPY dye through Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC) reaction

(2011) Chao Wang et al.   Science China-Chemistry

Site-Specific Orthogonal Labeling of the Carboxy Terminus of α-Tubulin

(2010) Abhijit Banerjee et al.   ACS Chemical Biology

A Metabolic Alkene Reporter for Spatiotemporally Controlled Imaging of Newly Synthesized Proteins in Mammalian Cells

(2010) Wenjiao Song et al.   ACS Chemical Biology

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

(2010) Jan Dommerholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells

(2010) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

Development of benzothiazole ‘click-on’ fluorogenic dyes

(2010) Jianjun Qi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of fluorogenic and quenched benzoxadiazole reactive chromophores

(2010) Jessie A. Key et al.   DYES AND PIGMENTS

BODIPY-Tetrazine Multichromophoric Derivatives

(2010) Cécile Dumas-Verdes et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Spectroscopic Characterization of Fluorescent Boron Dipyrromethene-Derived Hydrazones

(2010) Ozlem Dilek et al.   JOURNAL OF FLUORESCENCE

Real-Time Bioluminescence Imaging of Glycans on Live Cells

(2010) Allison S. Cohen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailored Ligand Acceleration of the Cu-Catalyzed Azide−Alkyne Cycloaddition Reaction: Practical and Mechanistic Implications

(2010) Stanislav I. Presolski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monitoring Protein−Polymer Conjugation by a Fluorogenic Cu(I)-Catalyzed Azide−Alkyne 1,3-Dipolar Cycloaddition

(2009) A. (Ton) J. Dirks et al.   BIOCONJUGATE CHEMISTRY

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Fluorogenic click reaction

(2009) Céline Le Droumaguet et al.   CHEMICAL SOCIETY REVIEWS

Photophysical characterization of triazole-substituted coumarin fluorophores

(2009) Jessie A. Key et al.   DYES AND PIGMENTS

Selective Labeling of Living Cells by a Photo-Triggered Click Reaction

(2009) Andrei A. Poloukhtine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-efficiency labeling of sialylated glycoproteins on living cells

(2009) Ying Zeng et al.   NATURE METHODS

Rapid Synthesis, Screening, and Identification of Xanthone- and Xanthene-Based Fluorophores Using Click Chemistry

(2009) Junqi Li et al.   ORGANIC LETTERS

A Photoinducible 1,3-Dipolar Cycloaddition Reaction for Rapid, Selective Modification of Tetrazole-Containing Proteins

(2008) Wenjiao Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A FRET-Based Fluorogenic Phosphine for Live-Cell Imaging with the Staudinger Ligation

(2008) Matthew J. Hangauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrolytic Stability of Hydrazones and Oximes

(2008) Jeet Kalia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

1,3-Dipolar cycloaddition of alkynes to azides. Construction of operationally functional metal responsive fluorophores

(2008) David Schweinfurth et al.   CHEMICAL COMMUNICATIONS

“Click-fluors”:  Modular Fluorescent Saccharide Sensors Based on a 1,2,3-Triazole Ring

(2008) David K. Scrafton et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective Functionalization of a Genetically Encoded Alkene-Containing Protein via “Photoclick Chemistry” in Bacterial Cells

(2008) Wenjiao Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Long-Wavelength Photoactivatable Diaryltetrazoles for Bioorthogonal 1,3-Dipolar Cycloaddition Reactions

(2008) Yizhong Wang et al.   ORGANIC LETTERS

1,2,3-Triazoles as Conjugative π-Linkers in Push−Pull Chromophores: Importance of Substituent Positioning on Intramolecular Charge-Transfer

(2008) Peter D. Jarowski et al.   ORGANIC LETTERS

A fluorogenic ‘click’ reaction of azidoanthracene derivatives

(2008) Fang Xie et al.   TETRAHEDRON

Synthesis of boron dipyrromethene fluorescent probes for bioorthogonal labeling

(2008) Özlem Dilek et al.   TETRAHEDRON LETTERS