Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy

ELABELA: a novel hormone in cardiac development acting as a new endogenous ligand for the APJ receptor

(2014) Feng Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway

(2014) Feng Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

(2014) You-Tong Wu et al.   Autophagy

Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy

(2014) Tania Zaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Apelin/APJ system: a promising therapy target for hypertension

(2014) Di Wu et al.   MOLECULAR BIOLOGY REPORTS

Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation

(2013) L. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis

(2013) Deguan Lv et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Class IA Phosphatidylinositol 3-Kinase Inhibition Inhibits Cell Growth and Proliferation in Mantle Cell Lymphoma

(2013) Yoko Tabe et al.   ACTA HAEMATOLOGICA

Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2013) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Post-infarct treatment with [Pyr1]-apelin-13 reduces myocardial damage through reduction of oxidative injury and nitric oxide enhancement in the rat model of myocardial infarction

(2013) Yaser Azizi et al.   PEPTIDES

Autophagy, a new target for disease treatment

(2013) Feng Xie et al.   Science China-Life Sciences

Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction

(2012) Lanfang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

APJ acts as a dual receptor in cardiac hypertrophy

(2012) Maria Cecilia Scimia et al.   NATURE

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

(2012) Chinatsu Otomo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Apelin-13 Promotes Monocyte Adhesion to Human Umbilical Vein Endothelial Cell Mediated by Phosphatidylinositol 3-Kinase Signaling Pathway*

(2012) Xiao-Huan MAO et al.   PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion

(2011) Jianping Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy

(2011) Yinan Hua et al.   BASIC RESEARCH IN CARDIOLOGY

Cardioprotective Effect of Apelin-13 on Cardiac Performance and Remodeling in End-Stage Heart Failure

(2011) Wataru Koguchi et al.   CIRCULATION JOURNAL

Identification and Characterization of Apelin Peptides in Bovine Colostrum and Milk by Liquid Chromatography–Mass Spectrometry

(2011) Cédric Mesmin et al.   JOURNAL OF PROTEOME RESEARCH

14-3-3 mediates apelin-13-induced enhancement of adhesion of monocytes to human umbilical vein endothelial cells

(2010) X. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13

(2010) C. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Roles ofPichia pastorisUvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways

(2010) Jean-Claude Farre et al.   Autophagy

MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells

(2010) Antonio Pérez-Pérez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin 1 Negatively Regulates Angiotensin II–Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7

(2010) Yanfei Yang et al.   CIRCULATION RESEARCH

PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis

(2010) Zahra Faghiri et al.   EXPERIMENTAL EYE RESEARCH

Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment?

(2010) Inês Falcão-Pires et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The role of PI3P phosphatases in the regulation of autophagy

(2010) Isabelle Vergne et al.   FEBS LETTERS

Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy

(2010) Camille Foussal et al.   FEBS LETTERS

Signaling responses after exposure to 5α-dihydrotestosterone or 17β-estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes

(2010) Yevgeniya E. Koshman et al.   JOURNAL OF APPLIED PHYSIOLOGY

Inhibition of PI3k Class III–Dependent Autophagy Prevents Apoptosis and Necrosis by Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2010) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection

(2010) Chengqun Huang et al.   Journal of Cardiovascular Translational Research

Effect of human umbilical cord blood cells on Ang-II-induced hypertrophy in mice

(2009) Sravan K. Vanamala et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

[Pyr 1 ]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart

(2009) Janet J. Maguire et al.   HYPERTENSION

Patterns of Structural and Functional Remodeling of the Left Ventricle in Chronic Heart Failure

(2008) William H. Gaasch et al.   AMERICAN JOURNAL OF CARDIOLOGY

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Propofol Depresses Angiotensin II–Induced Cardiomyocyte Hypertrophy In Vitro

(2008) Xiao-Jing Zou et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1

(2008) Feng Li   Frontiers in Bioscience-Landmark