Apelin/APJ system: a promising therapy target for hypertension

Unanticipated role of apelin: regulation of miRNA generation

(2013) D. Lv et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation

(2013) L. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis

(2013) Deguan Lv et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Fasting insulin concentrations and incidence of hypertension, stroke, and coronary heart disease: a meta-analysis of prospective cohort studies

(2013) Pengcheng Xun et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3

(2013) Heng Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Plasma apelin levels, blood pressure and cardiovascular risk factors in a coastal Chinese population

(2013) Pengli Zhu et al.   ANNALS OF MEDICINE

Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1

(2013) Qi-Feng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repeated electroacupuncture attenuating of apelin expression and function in the rostral ventrolateral medulla in stress-induced hypertensive rats

(2013) Cheng-Rong Zhang et al.   BRAIN RESEARCH BULLETIN

Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by ADMA

(2013) Xue Han et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Apelin Effects on Blood Pressure and RAS in DOCA-Salt-Induced Hypertensive Rats

(2013) Raziye Akcılar et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Insulin Resistance-Induced Hypertension and a Role of Perivascular CGRPergic Nerves

(2013) Shingo Takatori et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Redox Signaling Is an Early Event in the Pathogenesis of Renovascular Hypertension

(2013) Stella Hartono et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Masked Hypertension and Atherogenesis: The Impact of Apelin and Relaxin Plasma Levels

(2013) Dimitris P. Papadopoulos et al.   Journal of Clinical Hypertension

Apelin is a positive regulator of ACE2 in failing hearts

(2013) Teruki Sato et al.   JOURNAL OF CLINICAL INVESTIGATION

GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice

(2013) Pamela J. Davern et al.   JOURNAL OF HYPERTENSION

Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2013) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway

(2013) Qin Gu et al.   NEUROCHEMISTRY INTERNATIONAL

Apelin-13 Inhibits Large-Conductance Ca2+-Activated K+ Channels in Cerebral Artery Smooth Muscle Cells via a PI3-Kinase Dependent Mechanism

(2013) Amit Modgil et al.   PLoS One

Serum Uric Acid and Chronic Kidney Disease: The Role of Hypertension

(2013) Sanaz Sedaghat et al.   PLoS One

Role of insulin resistance in endothelial dysfunction

(2013) Ranganath Muniyappa et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Autophagy, a new target for disease treatment

(2013) Feng Xie et al.   Science China-Life Sciences

Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity

(2013) Kyungsoo Shin et al.   FEBS Open Bio

Polymorphisms of ACE2 are Associated with Blood Pressure Response to Cold Pressor Test: The GenSalt Study

(2012) Jianfeng Huang et al.   AMERICAN JOURNAL OF HYPERTENSION

Apelin–APJ induces ICAM-1, VCAM-1 and MCP-1 expression via NF-κB/JNK signal pathway in human umbilical vein endothelial cells

(2012) Ying Lu et al.   AMINO ACIDS

Hypertension and longitudinal changes in cerebral blood flow: The SMART-MR study

(2012) Majon Muller et al.   ANNALS OF NEUROLOGY

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor

(2012) Patrick R. Maloney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biology of the apelin-APJ axis in vascular formation

(2012) H. Kidoya et al.   JOURNAL OF BIOCHEMISTRY

Age-dependent regulation of renal vasopressin V1A and V2 receptors in rats with genetic hypertension: implications for the treatment of hypertension

(2012) Louise M. Burrell et al.   Journal of the American Society of Hypertension

Interactive Association of Five Candidate Polymorphisms in Apelin/APJ Pathway with Coronary Artery Disease among Chinese Hypertensive Patients

(2012) Wei Jin et al.   PLoS One

The Progress of Autophagy Involved in Heart Disease*

(2012) Feng XIE et al.   PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

14-3-3 Is Involved in ERK1/2 Signaling Pathway of Rat Vascular Smooth Muscle Cells Proliferation Induced by Apelin-13*

(2012) Wei-Nan PAN et al.   PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension

(2011) Yoshitaka Hirooka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice

(2011) Thibaut Duparc et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of a Competitive Apelin Receptor (APJ) Antagonist

(2011) N. J. Maximilian Macaluso et al.   ChemMedChem

Role of ACE2 in diastolic and systolic heart failure

(2011) Wang Wang et al.   HEART FAILURE REVIEWS

Angiotensin II receptor activation in youth triggers persistent insulin resistance and hypertension—a legacy effect?

(2011) Nobuhiko Togashi et al.   HYPERTENSION RESEARCH

Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes

(2011) Shunming Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Neuroendocrine Changes and Natriuresis in Response to Social Stress in Rats

(2011) A. Niebylski et al.   STRESS AND HEALTH

14-3-3 mediates apelin-13-induced enhancement of adhesion of monocytes to human umbilical vein endothelial cells

(2010) X. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13

(2010) C. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Evaluation of Renal Oxidative Stress in the Development of DOCA-Salt Induced Hypertension and Its Renal Damage

(2010) Behjat Seifi et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Plasma Apelin and ADMA Levels in Patients with Essential Hypertension

(2010) Alper Sonmez et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Effects of Olmesartan on Apelin/APJ and Akt/Endothelial Nitric Oxide Synthase Pathway in Dahl Rats With End-stage Heart Failure

(2010) Hiromichi Fukushima et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Apelin is necessary for the maintenance of insulin sensitivity

(2009) Patrick Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Apelin Gene Transfer Into the Rostral Ventrolateral Medulla Induces Chronic Blood Pressure Elevation in Normotensive Rats

(2009) Qi Zhang et al.   CIRCULATION RESEARCH

Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist

(2009) Xavier Iturrioz et al.   FASEB JOURNAL

Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese

(2009) Wei-Wei Li et al.   JOURNAL OF HYPERTENSION

Salt, Na+,K+-ATPase and hypertension

(2009) Ariel Jaitovich et al.   LIFE SCIENCES

Visfatin and apelin, new adipocytokines, and their relation to endothelial function in patients with chronic renal failure

(2008) J Malyszko et al.   Advances in Medical Sciences

Neurohormonal regulation of the sympathetic nervous system: New insights into central mechanisms of action

(2008) Scott H. Carlson et al.   CURRENT HYPERTENSION REPORTS

Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1

(2008) Feng Li   Frontiers in Bioscience-Landmark

Role of Inflammation in the Development of Renal Damage and Dysfunction in Angiotensin II–Induced Hypertension

(2008) Tang-Dong Liao et al.   HYPERTENSION

Jacques Benoit Lecture: The Neuroendocrine View of the Angiotensin and Apelin Systems

(2008) C. Llorens-Cortes et al.   JOURNAL OF NEUROENDOCRINOLOGY

Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli

(2008) M. Azizi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY