Cancer biomarker discovery: Current status and future perspectives

Abstract 2897: Discovery and characterization of driver MAPK and PI3K pathway mutations in tumors and association with drug response in cell lines.

(2014) Mark Tomilo et al.   CANCER RESEARCH

Hypoxia as a biomarker for radioresistant cancer stem cells

(2014) Claudia Peitzsch et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Cancer stem cell characteristics of circulating tumor cells

(2014) Ingeborg Tinhofer et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Phosphoprotein analysis reveals MEK inhibition as a way to target non-small cell lung cancer tumor initiating cells

(2014) Lovisa Lundholm et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

CXCR4 as biomarker for radioresistant cancer stem cells

(2014) Franziska Trautmann et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Molecular PET imaging for biology-guided adaptive radiotherapy of head and neck cancer

(2013) Bianca A. W. Hoeben et al.   ACTA ONCOLOGICA

Understanding and targeting cancer stem cells: therapeutic implications and challenges

(2013) Ke Chen et al.   ACTA PHARMACOLOGICA SINICA

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

(2013) Peter H Cashin et al.   BMC CANCER

Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair

(2013) B Groselj et al.   BRITISH JOURNAL OF CANCER

Individualised proteome profiling of human endometrial tumours improves detection of new prognostic markers

(2013) S Attarha et al.   BRITISH JOURNAL OF CANCER

Personalized radiation therapy and biomarker-driven treatment strategies: a systematic review

(2013) Jean-Emmanuel Bibault et al.   CANCER AND METASTASIS REVIEWS

Tumor Cell Dissemination: Emerging Biological Insights from Animal Models and Cancer Patients

(2013) Yibin Kang et al.   CANCER CELL

HER2 and Breast Cancer Stem Cells: More than Meets the Eye

(2013) H. Korkaya et al.   CANCER RESEARCH

Real-time Liquid Biopsy in Cancer Patients: Fact or Fiction?

(2013) K. Pantel et al.   CANCER RESEARCH

Breast cancer classification by proteomic technologies: Current state of knowledge

(2013) S.W. Lam et al.   CANCER TREATMENT REVIEWS

SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells

(2013) Adrian P. Rybak et al.   CELLULAR SIGNALLING

Chemotherapy and Radiotherapy Downregulate the Activity and Expression of DNA Methyltransferase and Enhance Bcl-2/E1B-19-kDa Interacting Protein-3-Induced Apoptosis in Human Colorectal Cancer Cells

(2013) Qian Deng et al.   CHEMOTHERAPY

Combined array CGH plus SNP genome analyses in a single assay for optimized clinical testing

(2013) Joanna Wiszniewska et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The role of high-throughput technologies in clinical cancer genomics

(2013) Saad F Idris et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma

(2013) Lei Ma et al.   FEBS Journal

Proteomics of cancer stem cells

(2013) Sergej Skvortsov et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Evaluation of High Ipsilateral Subventricular Zone Radiation Therapy Dose in Glioblastoma: A Pooled Analysis

(2013) Percy Lee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation-induced microRNA: Discovery, functional analysis, and cancer radiotherapy

(2013) M. Ahmad Chaudhry   JOURNAL OF CELLULAR BIOCHEMISTRY

Metabolomics in cancer biomarker discovery: Current trends and future perspectives

(2013) Emily G. Armitage et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics

(2013) Rashmi Kanagal-Shamanna et al.   MODERN PATHOLOGY

Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients

(2013) Helen Schneck et al.   Molecular Oncology

Translating next generation sequencing to practice: Opportunities and necessary steps

(2013) Sitharthan Kamalakaran et al.   Molecular Oncology

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

SDF-1 Promotes Endochondral Bone Repair during Fracture Healing at the Traumatic Brain Injury Condition

(2013) Xiaoqi Liu et al.   PLoS One

A Role of TGFß1 Dependent 14-3-3σ Phosphorylation at Ser69 and Ser74 in the Regulation of Gene Transcription, Stemness and Radioresistance

(2013) Olena Zakharchenko et al.   PLoS One

Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy

(2013) Marina Ferrarini et al.   PLoS One

Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

(2013) E. L. S. Fong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

(2013) S. Bea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of the cancer stem cell related determinants of radioresistance

(2013) Claudia Peitzsch et al.   RADIOTHERAPY AND ONCOLOGY

Clinical perspectives of cancer stem cell research in radiation oncology

(2013) Rebecca Bütof et al.   RADIOTHERAPY AND ONCOLOGY

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines

(2013) S Grosso et al.   Cell Death & Disease

The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem?

(2012) Eleftherios P Diamandis   BMC Medicine

Prognostic value of biologic subtype and the 21-gene recurrence score relative to local recurrence after breast conservation treatment with radiation for early stage breast carcinoma: results from the Eastern Cooperative Oncology Group E2197 study

(2012) Lawrence J. Solin et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumorigenic Cells Are Common in Mouse MPNSTs but Their Frequency Depends upon Tumor Genotype and Assay Conditions

(2012) Johanna Buchstaller et al.   CANCER CELL

High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2α

(2012) Ran-Ju Kim et al.   CANCER LETTERS

Novel Genetic Markers of Breast Cancer Survival Identified by a Genome-Wide Association Study

(2012) X. O. Shu et al.   CANCER RESEARCH

Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell Organization

(2012) A. Sottoriva et al.   CANCER RESEARCH

Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in Blood Using Error-Suppressed Multiplexed Deep Sequencing

(2012) A. Narayan et al.   CANCER RESEARCH

Cancer stem cells: In the line of fire

(2012) Malcolm R. Alison et al.   CANCER TREATMENT REVIEWS

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

(2012) Eleftherios Sachlos et al.   CELL

MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN

(2012) Changju Qu et al.   CELL CYCLE

Linking Glycogen and Senescence in Cancer Cells

(2012) Susana Ros et al.   Cell Metabolism

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

BEAMing Up Personalized Medicine: Mutation Detection in Blood

(2012) A. L. Richardson et al.   CLINICAL CANCER RESEARCH

Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

(2012) M. J. Higgins et al.   CLINICAL CANCER RESEARCH

Biomarker Discovery in Non-Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation

(2012) J. Botling et al.   CLINICAL CANCER RESEARCH

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Personalized medicine: hope or hype?

(2012) K. Salari et al.   EUROPEAN HEART JOURNAL

Detection of copy number alterations in acute myeloid leukemia and myelodysplastic syndromes

(2012) Meagan A Jacoby et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization

(2012) Virginia Tirino et al.   FASEB JOURNAL

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker Design

(2012) Salvador J. Diaz-Cano   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The evolving concept of cancer and metastasis stem cells

(2012) Irène Baccelli et al.   JOURNAL OF CELL BIOLOGY

Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma?

(2012) Tejpal Gupta et al.   JOURNAL OF NEURO-ONCOLOGY

Phosphorylated AKT and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecan-cetuximab

(2012) Mario Scartozzi et al.   Journal of Translational Medicine

EGFR mutations in circulating tumour DNA

(2012) Rafael Rosell et al.   LANCET ONCOLOGY

Individualization of cancer treatment from radiotherapy perspective

(2012) Ala Yaromina et al.   Molecular Oncology

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner

(2012) Christine W. Duarte et al.   PLoS One

High Accordance in Prognosis Prediction of Colorectal Cancer across Independent Datasets by Multi-Gene Module Expression Profiles

(2012) Wenting Li et al.   PLoS One

EGFR Kinase Promotes Acquisition of Stem Cell-Like Properties: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma Stem Cells

(2012) Eric L. Abhold et al.   PLoS One

γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers

(2012) Shibo Fu et al.   PLoS One

MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

(2012) Marek Svoboda et al.   Radiation Oncology

Plerixafor, a CXCR4 Antagonist, Mitigates Skin Radiation-Induced Injury in Mice

(2012) Jae Ho Kim et al.   RADIATION RESEARCH

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Cancer Stem Cells as a Predictive Factor in Radiotherapy

(2012) Thomas B. Brunner et al.   SEMINARS IN RADIATION ONCOLOGY

Effective Elimination of Cancer Stem Cells By a Novel Drug Combination Strategy

(2012) Shuqiang Yuan et al.   STEM CELLS

Predicting the response to preoperative radiation or chemoradiation by a microarray analysis of the gene expression profiles in rectal cancer

(2012) Takashi Akiyoshi et al.   SURGERY TODAY

PET imaging of CXCR4 using copper-64 labeled peptide antagonist

(2012) Orit Jacobson et al.   Theranostics

Chapter 11: Genome-Wide Association Studies

(2012) William S. Bush et al.   PLoS Computational Biology

Novel diagnostic biomarkers for prostate cancer

(2012) Chikezie O. Madu et al.   Journal of Cancer

Biomarkers: An Overview for Oncology Nurses

(2012) Ellen S. Richmond et al.   Seminars in Oncology Nursing

Circulating Tumors Cells as Biomarkers

(2011) Daniel C. Danila et al.   CANCER JOURNAL

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

Novel potential markers of nasopharyngeal carcinoma for diagnosis and therapy

(2011) Faqing Tang et al.   CLINICAL BIOCHEMISTRY

Cancer biomarker discovery: Opportunities and pitfalls in analytical methods

(2011) Haleem J. Issaq et al.   ELECTROPHORESIS

Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

(2011) A. J. Armstrong et al.   MOLECULAR CANCER RESEARCH

Polymorphisms inGSTM1andXPDgenes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy

(2011) Manoj B. Mahimkar et al.   MOLECULAR CARCINOGENESIS

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Practical implications of gene-expression-based assays for breast oncologists

(2011) Aleix Prat et al.   Nature Reviews Clinical Oncology

Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme

(2011) Marju Kase et al.   RADIOTHERAPY AND ONCOLOGY

Radiobiology goes 3D: How ECM and cell morphology impact on cell survival after irradiation

(2011) Iris Eke et al.   RADIOTHERAPY AND ONCOLOGY

DNA methylation changes in cells regrowing after fractioned ionizing radiation

(2011) Christine Kuhmann et al.   RADIOTHERAPY AND ONCOLOGY

Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours

(2011) Apostolos Menegakis et al.   RADIOTHERAPY AND ONCOLOGY

From RNAi Screens to Molecular Function in Embryonic Stem Cells

(2011) Li Ding et al.   Stem Cell Reviews and Reports

High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

(2011) David Sims et al.   GENOME BIOLOGY

Genomic Screening with RNAi: Results and Challenges

(2010) Stephanie Mohr et al.   Annual Review of Biochemistry

Identifying cancer driver genes in tumor genome sequencing studies

(2010) Ahrim Youn et al.   BIOINFORMATICS

Array comparative genomic hybridization analysis revealed four genomic prognostic biomarkers for primary gastric cancers

(2010) Nobumoto Tomioka et al.   CANCER GENETICS AND CYTOGENETICS

Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling

(2010) J. P. Sullivan et al.   CANCER RESEARCH

High Aldehyde Dehydrogenase Activity Identifies Tumor-Initiating and Metastasis-Initiating Cells in Human Prostate Cancer

(2010) Christel van den Hoogen et al.   CANCER RESEARCH

AACR-FDA-NCI Cancer Biomarkers Collaborative Consensus Report: Advancing the Use of Biomarkers in Cancer Drug Development

(2010) S. N. Khleif et al.   CLINICAL CANCER RESEARCH

Circulating tumor cells: a window into cancer biology and metastasis

(2010) Shyamala Maheswaran et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Current and emerging biomarkers in breast cancer: prognosis and prediction

(2010) Marion T Weigel et al.   ENDOCRINE-RELATED CANCER

Clinical Relevance of KRAS in Human Cancers

(2010) Sylwia Jančík et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mass spectrometry–based proteomics in cell biology

(2010) Tobias C. Walther et al.   JOURNAL OF CELL BIOLOGY

Targeting Breast Cancer Stem Cells

(2010) Suling Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Advances in understanding cancer genomes through second-generation sequencing

(2010) Matthew Meyerson et al.   NATURE REVIEWS GENETICS

Aldehyde dehydrogenase 1 positive glioblastoma cells show brain tumor stem cell capacity

(2010) M. Rasper et al.   NEURO-ONCOLOGY

Molecular Biomarker Analyses Using Circulating Tumor Cells

(2010) Elizabeth A. Punnoose et al.   PLoS One

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation

(2010) Dan Yan et al.   PLoS One

Non-Invasive In Vivo Imaging of Tumor-Associated CD133/Prominin

(2010) Chizuko Tsurumi et al.   PLoS One

Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate

(2010) Francesca Pistollato et al.   STEM CELLS

The Use of FDG-PET to Target Tumors by Radiotherapy

(2010) Guido Lammering et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Using Functional Genetics to Understand Breast Cancer Biology

(2010) A. Ashworth et al.   Cold Spring Harbor Perspectives in Biology

Cancer Biomarkers: Are We Ready for the Prime Time?

(2010) Alok Mishra et al.   Cancers

Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies

(2009) A Diaz Miqueli et al.   BRITISH JOURNAL OF CANCER

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Changes in Gene Expression Predicting Local Control in Cervical Cancer: Results from Radiation Therapy Oncology Group 0128

(2009) J. B. Weidhaas et al.   CLINICAL CANCER RESEARCH

Detection of KRAS Oncogene in Peripheral Blood as a Predictor of the Response to Cetuximab Plus Chemotherapy in Patients with Metastatic Colorectal Cancer

(2009) L.-C. Yen et al.   CLINICAL CANCER RESEARCH

Basic Concepts of Microarrays and Potential Applications in Clinical Microbiology

(2009) M. B. Miller et al.   CLINICAL MICROBIOLOGY REVIEWS

Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by γH2AX staining

(2009) Apostolos Menegakis et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Acute Normal Tissue Reactions in Head-and-Neck Cancer Patients Treated With IMRT: Influence of Dose and Association With Genetic Polymorphisms in DNA DSB Repair Genes

(2009) Joke Werbrouck et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances

(2009) T. LaFramboise   NUCLEIC ACIDS RESEARCH

Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell Markers

(2009) Wendy W. Hwang-Verslues et al.   PLoS One

Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy 18Fluorodeoxyglucose-PET-CT scan

(2009) Hugo J.W.L. Aerts et al.   RADIOTHERAPY AND ONCOLOGY

Is pre-therapeutical FDG-PET/CT capable to detect high risk tumor subvolumes responsible for local failure in non-small cell lung cancer?

(2009) Andrij Abramyuk et al.   RADIOTHERAPY AND ONCOLOGY

Glycolytic metabolism and tumour response to fractionated irradiation

(2009) Ulrike G.A. Sattler et al.   RADIOTHERAPY AND ONCOLOGY

Therapeutic Implications of the Cancer Stem Cell Hypothesis

(2009) Maximilian Diehn et al.   SEMINARS IN RADIATION ONCOLOGY

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Identification of CDK10 as an Important Determinant of Resistance to Endocrine Therapy for Breast Cancer

(2008) Elizabeth Iorns et al.   CANCER CELL

Growth Inhibition and Radiosensitization of Glioblastoma and Lung Cancer Cells by Small Interfering RNA Silencing of Tumor Necrosis Factor Receptor-Associated Factor 2

(2008) M. Zheng et al.   CANCER RESEARCH

Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235

(2008) P. J.A. Eichhorn et al.   CANCER RESEARCH

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE

Grading of brain glioma with 1-11C-acetate PET: comparison with 18F-FDG PET

(2008) Tatsuro Tsuchida et al.   NUCLEAR MEDICINE AND BIOLOGY

The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations

(2008) A. Dubrovska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells

(2008) Ira Skvortsova et al.   PROTEOMICS