Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker Design

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

Paratumoral gene expression profiles: promising markers of malignancy in melanocytic lesions

(2011) S.J. Diaz-Cano   BRITISH JOURNAL OF DERMATOLOGY

Noninvasive genomic detection of melanoma

(2011) W. Wachsman et al.   BRITISH JOURNAL OF DERMATOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Medusa structure of the gene regulatory network: dominance of transcription factors in cancer subtype classification

(2011) Yuchun Guo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Intratumor Heterogeneity in Evolutionary Models of Tumor Progression

(2011) Rick Durrett et al.   GENETICS

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

(2011) Hasan Korkaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneity in breast cancer

(2011) Kornelia Polyak   JOURNAL OF CLINICAL INVESTIGATION

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneous topographic profiles of kinetic and cell cycle regulator microsatellites in atypical (dysplastic) melanocytic nevi

(2011) Ehab A Husain et al.   MODERN PATHOLOGY

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

(2011) Héctor Peinado et al.   SEMINARS IN CANCER BIOLOGY

Molecular morphometric analysis shows relative intra-tumoural homogeneity for KRAS mutations in colorectal cancer

(2011) Liora Farber et al.   VIRCHOWS ARCHIV

Oncogenic microRNAs (OncomiRs) as a new class of cancer biomarkers

(2010) Vladimir A. Krutovskikh et al.   BIOESSAYS

Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis

(2010) J.-H. Lee et al.   BRITISH JOURNAL OF DERMATOLOGY

The Origins and Implications of Intratumor Heterogeneity

(2010) F. Michor et al.   Cancer Prevention Research

An Ex(o)citing Machinery for Invasive Tumor Growth

(2010) A. Hendrix et al.   CANCER RESEARCH

Intracellular and Extracellular MicroRNAs in Breast Cancer

(2010) C. Corcoran et al.   CLINICAL CHEMISTRY

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

(2010) So Yeon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Tracing the origins of metastasis

(2010) Don X Nguyen   JOURNAL OF PATHOLOGY

Genetic changes in tumour microenvironments

(2010) Ian Campbell et al.   JOURNAL OF PATHOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Microenvironmental Independence Associated with Tumor Progression

(2009) A. R.A. Anderson et al.   CANCER RESEARCH

Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors

(2009) A. Marusyk et al.   CANCER RESEARCH

Adaptive Therapy

(2009) R. A. Gatenby et al.   CANCER RESEARCH

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

(2009) Yuri Kim et al.   CURRENT MOLECULAR MEDICINE

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

(2009) Alberto Mantovani et al.   HUMAN IMMUNOLOGY

Coexistent intraurothelial carcinoma and muscle-invasive urothelial carcinoma of the bladder: clonality and somatic down-regulation of DNA mismatch repair

(2009) Alfredo Blanes et al.   HUMAN PATHOLOGY

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

(2009) Sohrab P. Shah et al.   NATURE

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

(2009) Wennuan Liu et al.   NATURE MEDICINE

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

(2009) K. D. Siegmund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral Heterogeneity for Expression of Tyrosine Kinase Growth Factor Receptors in Human Colon Cancer Surgical Specimens and Orthotopic Tumors

(2008) Toshio Kuwai et al.   AMERICAN JOURNAL OF PATHOLOGY

Liver Repopulation and Carcinogenesis: Two Sides of the Same Coin?

(2008) Fabio Marongiu et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Pathobiology of Gastrointestinal Stromal Sarcomas

(2008) Christopher L. Corless et al.   Annual Review of Pathology-Mechanisms of Disease

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer

(2008) S Maeda et al.   BRITISH JOURNAL OF CANCER

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer

(2008) Nikolas H. Stoecklein et al.   CANCER CELL

Hypoxia-induced secretion of macrophage migration-inhibitory factor from MCF-7 breast cancer cells is regulated in a hypoxia-inducible factor-independent manner

(2008) Mona Larsen et al.   CANCER LETTERS

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

(2008) Sean J. Morrison et al.   CELL

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

(2008) Sandra S. McAllister et al.   CELL

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

A microRNA component of the hypoxic response

(2008) R Kulshreshtha et al.   CELL DEATH AND DIFFERENTIATION

Recent advances in cancer stem cells

(2008) Robert W Cho et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Impact of cyclic hypoxia on HIF-1α regulation in endothelial cells - new insights for anti-tumor treatments

(2008) Philippe Martinive et al.   FEBS Journal

Design and analysis issues in genome-wide somatic mutation studies of cancer

(2008) Giovanni Parmigiani et al.   GENOMICS

General morphological and biological features of neoplasms: integration of molecular findings

(2008) S J Diaz-Cano   HISTOPATHOLOGY

Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration

(2008) Maria Carla Bosco et al.   IMMUNOBIOLOGY

Cancer stem cells: implications for the progression and treatment of metastatic disease

(2008) A.K Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Skewing the Th cell phenotype toward Th1 alters the maturation of tumor-infiltrating mononuclear phagocytes

(2008) Kenichi Nonaka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics

(2008) Naoki Umemura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microenvironment driven invasion: a multiscale multimodel investigation

(2008) Alexander R. A. Anderson et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Endothelial cells and normal breast epithelial cells enhance invasion of breast carcinoma cells by CXCR-4-dependent up-regulation of urokinase-type plasminogen activator receptor (uPAR, CD87) expression

(2008) S Serratì et al.   JOURNAL OF PATHOLOGY

New insights on the role of CXCR4 in cancer metastasis

(2008) A Zlotnik   JOURNAL OF PATHOLOGY

Human tumour clonality assessment-flawed but necessary

(2008) SJ Leedham et al.   JOURNAL OF PATHOLOGY

Resistance to therapy caused by intragenic deletion in BRCA2

(2008) Stacey L. Edwards et al.   NATURE

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

Coevolution in the tumor microenvironment

(2008) Robert A Weinberg   NATURE GENETICS

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

(2008) P. J. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CANCER BIOLOGY: All in the Stroma: Cancer's Cosa Nostra

(2008) J. Marx   SCIENCE

Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung

(2008) K. Podsypanina et al.   SCIENCE

CANCER IMMUNOLOGY: Cancer's Bulwark Against Immune Attack: MDS Cells

(2008) J. Marx   SCIENCE

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Cancer development at tissue level

(2008) Ezio Laconi et al.   SEMINARS IN CANCER BIOLOGY

The microenvironments of multistage carcinogenesis

(2008) Ezio Laconi et al.   SEMINARS IN CANCER BIOLOGY

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY

The Cancer Stem Cell–Vascular Niche Complex in Brain Tumor Formation

(2008) Anand Veeravagu et al.   STEM CELLS AND DEVELOPMENT

Co-evolution of tumor cells and their microenvironment

(2008) Kornelia Polyak et al.   TRENDS IN GENETICS

The correlation of regression with the grade of dysplasia (atypia) in melanocytic naevi

(2007) L Pozo et al.   HISTOPATHOLOGY