Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling

Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells

(2018) Yena Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3

(2017) Chen Qi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells

(2017) Zhuqing Liu et al.   Oncotarget

Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development

(2017) Hyunseung Lee et al.   Scientific Reports

TC-PTP regulates the IL-7 transcriptional response during murine early T cell development

(2017) K. A. Pike et al.   Scientific Reports

SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer

(2017) Yan Huang et al.   Scientific Reports

The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A

(2016) Dongmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis

(2016) Yiqing Zhao et al.   Oncotarget

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System

(2016) Xueting Luo et al.   Cell Reports

Receptor-type tyrosine-protein phosphatase   directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma

(2015) Y.-W. Chen et al.   BLOOD

Functions of Shp2 in cancer

(2015) Jie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Notch and TGF-β pathways cooperatively regulate receptor protein tyrosine phosphatase-κ (PTPRK) gene expression in human primary keratinocytes

(2015) Yiru Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer

(2015) N D Peyser et al.   ONCOGENE

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

(2015) Noah D. Peyser et al.   PLoS One

Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma

(2015) Christos Demosthenous et al.   Oncotarget

Mutational and Functional Analysis of the Tumor-Suppressor PTPRD in Human Melanoma

(2014) Vijay Walia et al.   HUMAN MUTATION

Activation of T-cell Protein-tyrosine Phosphatase Suppresses Keratinocyte Survival and Proliferation following UVB Irradiation

(2014) Hyunseung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β1,6 GlcNAc Branches-Modified PTPRT Attenuates Its Activity and Promotes Cell Migration by STAT3 Pathway

(2014) Jingjing Qi et al.   PLoS One

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

(2014) B. Ortiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

(2014) V. W. Y. Lui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

(2014) Tomoaki Ando et al.   Cell Reports

SHP2 Is Overexpressed and Inhibits pSTAT1-Mediated APM Component Expression, T-cell Attracting Chemokine Secretion, and CTL Recognition in Head and Neck Cancer Cells

(2013) M. S. Leibowitz et al.   CLINICAL CANCER RESEARCH

p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth

(2013) Mercedes Tkach et al.   ENDOCRINE-RELATED CANCER

Receptor-like protein tyrosine phosphatase κ negatively regulates the apoptosis of prostate cancer cells via the JNK pathway

(2013) PING-HUI SUN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer

(2013) Ping-Hui Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Shp1 regulates T cell homeostasis by limiting IL-4 signals

(2013) Dylan J. Johnson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evidence against a Role for β-Arrestin1 in STAT1 Dephosphorylation and the Inhibition of Interferon-γ Signaling

(2013) Christin Pelzel et al.   MOLECULAR CELL

Tumor Derived Mutations of Protein Tyrosine Phosphatase Receptor Type K Affect Its Function and Alter Sensitivity to Chemotherapeutics in Glioma

(2013) Supreet Agarwal et al.   PLoS One

Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells

(2012) Qin Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity

(2012) Kuen-Feng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

(2012) Prasad Tammineni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers

(2012) Benjamin J. Shields et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumour suppressor function of protein tyrosine phosphatase receptor-T

(2011) Anthony Scott et al.   BIOSCIENCE REPORTS

A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells

(2011) L. Li et al.   BLOOD

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

The protein tyrosine phosphatase receptor D, a broadly inactivated tumor suppressor regulating STAT function

(2011) Timothy A. Chan et al.   CELL CYCLE

Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma

(2011) M. Kleppe et al.   HAEMATOLOGICA

Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation

(2011) Wei Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1-Mediated Inhibition of STAT3

(2011) W.-T. Tai et al.   MOLECULAR CANCER THERAPEUTICS

Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44

(2011) KOSUKE FUNATO et al.   Experimental and Therapeutic Medicine

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

(2011) Eleonora A. M. Festen et al.   PLoS Genetics

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

(2010) Wendell A. Lim et al.   CELL

Cancer-Derived Mutations in the Fibronectin III Repeats of PTPRT/PTPρ Inhibit Cell-Cell Aggregation

(2010) Peng Zhang et al.   CELL COMMUNICATION AND ADHESION

Characterization of the Adhesive Properties of the Type IIb Subfamily Receptor Protein Tyrosine Phosphatases

(2010) Scott Becka et al.   CELL COMMUNICATION AND ADHESION

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

(2010) Atsushi Fukushima et al.   DIABETES

Neutrophils Require SHP1 To Regulate IL-1  Production and Prevent Inflammatory Skin Disease

(2010) B. A. Croker et al.   JOURNAL OF IMMUNOLOGY

5-Hydroxy-2-Methyl-1,4-Naphthoquinone, a Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization

(2010) S. K. Sandur et al.   MOLECULAR CANCER RESEARCH

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation

(2010) Dae Joon Kim et al.   PLoS One

Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T

(2010) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGF-mediated migration signaling activated by N-acetylglucosaminyltransferase-V via receptor protein tyrosine phosphatase kappa

(2009) Can Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tumor Suppression by Phospholipase C-β3 via SHP-1-Mediated Dephosphorylation of Stat5

(2009) Wenbin Xiao et al.   CANCER CELL

Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

(2009) D. J. Kim et al.   CANCER RESEARCH

Tyrosine phosphorylation: thirty years and counting

(2009) Tony Hunter   CURRENT OPINION IN CELL BIOLOGY

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn

(2009) So-Hee Lim et al.   EMBO JOURNAL

Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis

(2009) D J Kim et al.   ONCOGENE

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

(2009) T. K. Starr et al.   SCIENCE

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1

(2008) K. S. Ahn et al.   CANCER RESEARCH

Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis

(2008) K. Kataoka et al.   CARCINOGENESIS

Tumor-Derived Extracellular Mutations of PTPRT/PTP  Are Defective in Cell Adhesion

(2008) J. Yu et al.   MOLECULAR CANCER RESEARCH

Nuclear β-Arrestin1 Functions as a Scaffold for the Dephosphorylation of STAT1 and Moderates the Antiviral Activity of IFN-γ

(2008) Wei Mo et al.   MOLECULAR CELL