SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer

Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3

(2017) Chen Qi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

(2016) E. Van Cutsem et al.   ANNALS OF ONCOLOGY

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

(2016) B M Richine et al.   LEUKEMIA

CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer

(2016) Piero Dalerba et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endoplasmic reticulum ribosome-binding protein 1, RRBP1, promotes progression of colorectal cancer and predicts an unfavourable prognosis

(2015) Y Pan et al.   BRITISH JOURNAL OF CANCER

Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium

(2014) Hironori Yamashita et al.   PLoS One

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

(2014) Julian Heuberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma

(2013) Wenjun Chang et al.   GUT

Growth arrest and DNA damage 45G down-regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma

(2013) Li Zhang et al.   HEPATOLOGY

Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

(2013) G. Coulombe et al.   MOLECULAR AND CELLULAR BIOLOGY

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

(2012) S C Nabinger et al.   LEUKEMIA

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

STAT3 Expression, Molecular Features, Inflammation Patterns, and Prognosis in a Database of 724 Colorectal Cancers

(2011) Teppei Morikawa et al.   CLINICAL CANCER RESEARCH

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

(2011) Cihangir Duy et al.   NATURE

STAT3 Implicated in the Development of Colon Cancer: A Step Closer for Targeted Therapy?

(2010) George K.K. Lau et al.   GASTROENTEROLOGY

Colorectal cancer

(2010) David Cunningham et al.   LANCET

Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer

(2010) S Danese et al.   ONCOGENE

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2

(2009) Boris R. A. Blechacz et al.   HEPATOLOGY

Polymorphisms of PTPN11 Coding SHP-2 as Biomarkers for Ulcerative Colitis Susceptibility in the Japanese Population

(2009) Yukiko Narumi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

(2009) Mustafa Benekli et al.   JOURNAL OF CLINICAL ONCOLOGY

STAT3 as a target for inducing apoptosis in solid and hematological tumors

(2008) Khandaker Al Zaid Siddiquee et al.   CELL RESEARCH

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA