β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte

Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated β3 -adrenergic receptor activation in high-fat diet-induced obese mice

(2017) Yimin Jia et al.   EXPERIMENTAL PHYSIOLOGY

The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1

(2017) Sabrina Chriett et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes

(2017) Ha-Eun Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

(2017) Matthew J. Emmett et al.   NATURE

Histone deacetylases inhibitors (HDACis) as novel therapeutic application in various clinical diseases

(2017) Xiaoyan Qiu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

(2017) Alessandra Ferrari et al.   Nature Communications

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

(2016) Niek G.J. Leus et al.   BIOCHEMICAL PHARMACOLOGY

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

(2016) Niek GJ Leus et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Are epigenetic drugs for diabetes and obesity at our door step?

(2016) Andrix O. Arguelles et al.   DRUG DISCOVERY TODAY

Inside HDACs with more selective HDAC inhibitors

(2016) Joëlle Roche et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases

(2016) Alokta Chakrabarti et al.   Future Medicinal Chemistry

Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases

(2016) A Ferrari et al.   INTERNATIONAL JOURNAL OF OBESITY

Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation

(2016) Fenfen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetes

(2016) Sorabh Sharma et al.   PHARMACOLOGICAL RESEARCH

Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice

(2016) Jian Hong et al.   Oncotarget

Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

(2016) Chandrakumar Sathishkumar et al.   Clinical Epigenetics

Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning

(2015) Tara M Henagan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

(2015) Madhusoodanan Mottamal et al.   MOLECULES

HDAC8: a multifaceted target for therapeutic interventions

(2015) Alokta Chakrabarti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity

(2015) Xiao-Rong Peng et al.   Frontiers in Endocrinology

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

(2014) Emilio P. Mottillo et al.   JOURNAL OF LIPID RESEARCH

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes

(2014) John M. Rumberger et al.   PeerJ

Improving Insulin Sensitivity With HDAC Inhibitor

(2013) J. Ye   DIABETES

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Synergism between cAMP and PPARγSignalling in the Initiation of UCP1 Gene Expression in HIB1B Brown Adipocytes

(2013) H. Y. Chen et al.   PPAR Research

HDAC8 substrates: Histones and beyond

(2012) Noah A. Wolfson et al.   BIOPOLYMERS

Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

(2012) A. Galmozzi et al.   DIABETES

Ephedrine activates brown adipose tissue in lean but not obese humans

(2012) A. L. Carey et al.   DIABETOLOGIA

Metabolic reprogramming by class I and II histone deacetylases

(2012) Maria M. Mihaylova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

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(2011) Dan Christensen et al.   MOLECULAR MEDICINE

HDAC Inhibition Attenuates Inflammatory, Hypertrophic, and Hypertensive Responses in Spontaneously Hypertensive Rats

(2010) Jeffrey P. Cardinale et al.   HYPERTENSION

Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks

(2010) S Collins et al.   INTERNATIONAL JOURNAL OF OBESITY

Regulating the Regulators: The Post-Translational Code of Class I HDAC1 and HDAC2

(2010) Chiara V. Segré et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates

(2010) Ya-Li Yao et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylases: salesmen and customers in the post-translational modification market

(2009) André Brandl et al.   BIOLOGY OF THE CELL

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages

(2009) Shizuka Hirai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation

(2008) Min-Sook Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS