MicroRNA Signatures as Biomarkers and Therapeutic Target for CNS Embryonal Tumors: The Pros and the Cons

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Frequent Overexpression ofHMGA2in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation withlet-7a3/let-7bmiRNA

(2014) Keqiang Zhang et al.   CLINICAL CANCER RESEARCH

miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164

(2014) JIA-ANG SHI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Significance and Therapeutic Value of miRNAs in Embryonal Neural Tumors

(2014) Tarek Shalaby et al.   MOLECULES

The roles of microRNAs in neuroblastoma

(2014) Hong Mei et al.   World Journal of Pediatrics

A Plasma MicroRNA Panel for Detection of Colorectal Adenomas

(2013) Ziad Kanaan et al.   ANNALS OF SURGERY

Prognostic value of microRNA expression pattern in upper tract urothelial carcinoma

(2013) Laura Izquierdo et al.   BJU INTERNATIONAL

Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma

(2013) G Fiaschetti et al.   BRITISH JOURNAL OF CANCER

Silencing of the miR-17 92 Cluster Family Inhibits Medulloblastoma Progression

(2013) B. L. Murphy et al.   CANCER RESEARCH

Circulating MicroRNAs: A Novel Class of Potential Biomarkers for Diagnosing and Prognosing Central Nervous System Diseases

(2013) Xue-Feng Jin et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases

(2013) Zhen Zhao et al.   CLINICAL BIOCHEMISTRY

MicroRNAs in the ionizing radiation response and in radiotherapy

(2013) Chanatip Metheetrairut et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Medulloblastoma molecular dissection

(2013) Marc Remke et al.   CURRENT OPINION IN ONCOLOGY

Diagnostic and prognostic value of circulating miR-21 for cancer: A systematic review and meta-analysis

(2013) Yang Wang et al.   GENE

Real-time PCR assay based on the differential expression of microRNAs and protein-coding genes for molecular classification of formalin-fixed paraffin embedded medulloblastomas

(2013) Ratika Kunder et al.   NEURO-ONCOLOGY

The Role of microRNAs in Medulloblastoma

(2013) Daniel Onofre Vidal et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

(2013) Andrej Besse et al.   TUMOR BIOLOGY

MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex

(2013) Shan Bian et al.   Cell Reports

Role of MYC in Medulloblastoma

(2013) M. F. Roussel et al.   Cold Spring Harbor Perspectives in Medicine

MicroRNAs as biomarkers for CNS disease

(2013) Pooja Rao et al.   Frontiers in Molecular Neuroscience

Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma

(2012) Shyamal Dilhan Weeraratne et al.   ACTA NEUROPATHOLOGICA

Developing MicroRNA Therapeutics

(2012) Eva van Rooij et al.   CIRCULATION RESEARCH

Clinical Applications for microRNAs in Cancer

(2012) S P Nana-Sinkam et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The hunting of targets: challenge in miRNA research

(2012) F Akbari Moqadam et al.   LEUKEMIA

MicroRNA profiling: approaches and considerations

(2012) Colin C. Pritchard et al.   NATURE REVIEWS GENETICS

MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity

(2012) N. M. Teplyuk et al.   NEURO-ONCOLOGY

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

(2011) Alfa H. C. Bai et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Analytical aspects of microRNA in diagnostics: A review

(2011) Mariàngels de Planell-Saguer et al.   ANALYTICA CHIMICA ACTA

Normal and oncogenic roles for microRNAs in the developing brain

(2011) Africa Fernandez-L et al.   CELL CYCLE

The Art of MicroRNA Research

(2011) Eva van Rooij   CIRCULATION RESEARCH

MicroRNA-21 suppression impedes medulloblastoma cell migration

(2011) Eveline Grunder et al.   EUROPEAN JOURNAL OF CANCER

MicroRNAs as new therapeutic targets and tools in cancer

(2011) Paolo Gandellini et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Developing therapeutic microRNAs for cancer

(2011) A G Bader et al.   GENE THERAPY

Comparison of Effect Sizes Associated With Biomarkers Reported in Highly Cited Individual Articles and in Subsequent Meta-analyses

(2011) John P. A. Ioannidis   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Up-regulation ofmiR-21Mediates Resistance to Trastuzumab Therapy for Breast Cancer

(2011) Chang Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway

(2011) NeelamVishwanath Shirsat et al.   Journal of Cancer Research and Therapeutics

FSTL5Is a Marker of Poor Prognosis in Non-WNT/Non-SHH Medulloblastoma

(2011) Marc Remke et al.   JOURNAL OF CLINICAL ONCOLOGY

miRNA Profiling for Clear Cell Renal Cell Carcinoma: Biomarker Discovery and Identification of Potential Controls and Consequences of miRNA Dysregulation

(2011) Nicole M.A. White et al.   JOURNAL OF UROLOGY

Extracellular microRNA: A new source of biomarkers

(2011) Alton Etheridge et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma

(2011) A. Baraniskin et al.   NEURO-ONCOLOGY

MicroRNAs as biomarkers for CNS cancer and other disorders

(2010) Enrico De Smaele et al.   BRAIN RESEARCH

MicroRNA in lung cancer

(2010) P-Y Lin et al.   BRITISH JOURNAL OF CANCER

hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion and side populations

(2010) F Wang et al.   BRITISH JOURNAL OF CANCER

Strengths and Limitations of Laboratory Procedures for MicroRNA Detection

(2010) J. Koshiol et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Self-renewal mechanisms in neural cancer stem cells

(2010) Theo Mantamadiotis   Frontiers in Bioscience-Landmark

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

The clinical potential of microRNAs

(2010) Anuradha Budhu et al.   Journal of Hematology & Oncology

mRNA and microRNA Expression Profiles of the NCI-60 Integrated with Drug Activities

(2010) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

(2010) Konstantinos J. Mavrakis et al.   NATURE CELL BIOLOGY

Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment

(2010) Mariàngels de Planell-Saguer et al.   Nature Protocols

Metastamirs: a stepping stone towards improved cancer management

(2010) Nicole M. A. White et al.   Nature Reviews Clinical Oncology

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of microRNAs in brain tumor biology

(2010) Jay D. Turner et al.   Neurosurgical Focus

A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing

(2010) Eulàlia Martí et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma

(2010) Johannes H. Schulte et al.   NUCLEIC ACIDS RESEARCH

Systemic miRNA-195 Differentiates Breast Cancer from Other Malignancies and Is a Potential Biomarker for Detecting Noninvasive and Early Stage Disease

(2010) H. M. Heneghan et al.   ONCOLOGIST

Survey of MicroRNA expression in pediatric brain tumors

(2010) Diane K. Birks et al.   PEDIATRIC BLOOD & CANCER

MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence

(2010) Sujatha Venkataraman et al.   PLoS One

What is a biomarker? Research investments and lack of clinical integration necessitate a review of biomarker terminology and validation schema

(2010) Adam S. Ptolemy et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications

(2009) Jeffrey T. DeSano et al.   AAPS Journal

Oncogenic role of microRNAs in brain tumors

(2009) Jesse Chung-sean Pang et al.   ACTA NEUROPATHOLOGICA

MicroRNA detection by microarray

(2009) Wei Li et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors

(2009) Meihua Li et al.   CANCER CELL

MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood-Based Biomarkers of Disease

(2009) J. Wang et al.   Cancer Prevention Research

The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog-Treated Cerebellar Neural Precursors

(2009) P. A. Northcott et al.   CANCER RESEARCH

MicroRNAs and Cancer: Short RNAs Go a Long Way

(2009) Andrea Ventura et al.   CELL

Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targets

(2009) Simone Treiger Sredni et al.   CHILDS NERVOUS SYSTEM

microRNA Profiling Identifies Cancer-Specific and Prognostic Signatures in Pediatric Malignancies

(2009) J. S. Wei et al.   CLINICAL CANCER RESEARCH

In Vivo Cellular Imaging for Translational Medical Research

(2009) Ali Arbab et al.   Current Medical Imaging Reviews

MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types

(2009) Richard Hummel et al.   EUROPEAN JOURNAL OF CANCER

Basic and translational research: from molecule, to mouse, to man

(2009) Volker Adams et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Challenges in cancer research and multifaceted approaches for cancer biomarker quest

(2009) Jirina Martinkova et al.   FEBS LETTERS

miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1

(2009) Kay Ka Wai Li et al.   HUMAN PATHOLOGY

From bench to bedside: current and future applications of molecular profiling in renal cell carcinoma

(2009) Androu Arsanious et al.   Molecular Cancer

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

(2009) Andrew S. Yoo et al.   NATURE

Repeatability of published microarray gene expression analyses

(2009) John P A Ioannidis et al.   NATURE GENETICS

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Limitations and possibilities of small RNA digital gene expression profiling

(2009) Sam E V Linsen et al.   NATURE METHODS

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

Translational informatics: enabling high-throughput research paradigms

(2009) Philip R. O. Payne et al.   PHYSIOLOGICAL GENOMICS

MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma

(2009) Livia Garzia et al.   PLoS One

Amplification and Overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in Medulloblastoma

(2009) Yuan Lu et al.   PLoS One

ThemiR-17∼92cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

(2009) Tamar Uziel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Planning for translational research in genomics

(2009) Naomi Hawkins et al.   Genome Medicine

Bridging the gap between systems biology and medicine

(2009) Gilles Clermont et al.   Genome Medicine

MicroRNAs as biomarkers and therapeutic drugs in human cancer

(2008) M. Osaki et al.   BIOMARKERS

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

(2008) Joachim Silber et al.   BMC Medicine

MiR-92b and miR-9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors

(2008) Dvora Nass et al.   BRAIN PATHOLOGY

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

(2008) Zeng-Jie Yang et al.   CANCER CELL

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Validation of Analytic Methods for Biomarkers Used in Drug Development

(2008) C. H. Chau et al.   CLINICAL CANCER RESEARCH

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

(2008) Elisabetta Ferretti et al.   EMBO JOURNAL

MicroRNA profiling in human medulloblastoma

(2008) Elisabetta Ferretti et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma

(2008) Aaron J. Schetter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer

(2008) Mohd W. Nasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Medulloblastoma Stem Cells

(2008) Xing Fan et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma

(2008) Jessica Pierson et al.   JOURNAL OF NEURO-ONCOLOGY

MicroRNAs modulate the chemosensitivity of tumor cells

(2008) P. E. Blower et al.   MOLECULAR CANCER THERAPEUTICS

Report on EU-USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008)

(2008) Ruedi Aebersold et al.   Molecular Oncology

MicroRNAs accurately identify cancer tissue origin

(2008) Nitzan Rosenfeld et al.   NATURE BIOTECHNOLOGY

Gewebebank des Nationalen Zentrums für Tumorerkrankungen

(2008) E. Herpel et al.   PATHOLOGE

The Genomic Analysis of Erythrocyte microRNA Expression in Sickle Cell Diseases

(2008) Shao-Yin Chen et al.   PLoS One

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state

(2008) S.-L. Lin et al.   RNA

MicroRNA Discovery and Profiling in Human Embryonic Stem Cells by Deep Sequencing of Small RNA Libraries

(2008) Merav Bar et al.   STEM CELLS

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY

Micromanagers of malignancy: role of microRNAs in regulating metastasis

(2008) Li Ma et al.   TRENDS IN GENETICS