Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Chun Kwon, Seong-Ho Ok, Seung Hyun Ahn, Sung Il Bae, Ji-Yoon Kim, Yeran Hwang, Kyeong-Eon Park, Mingu Kim, Ju-Tae Sohn
Summary: In this study, the researchers investigated the involvement of aortic contraction induced by dexmedetomidine in the transactivation of EGFR in endothelium-denuded rat aortas. They found that the activation of alpha-2 adrenoceptor, Src kinase, and matrix metalloproteinase mediated the contraction and subsequent JNK phosphorylation and increased calcium levels. These findings provide insights into the cellular mechanisms underlying dexmedetomidine-induced effects on aortic contraction and EGFR transactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Michael Gekle, Virginie Dubourg, Gerald Schwerdt, Ralf A. Benndorf, Barbara Schreier
Summary: EGFR plays a critical role in the regulation of vascular function and pathogenesis of cardiovascular diseases through the interplay with AT1R.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Danielle Kamato, Mai Gabr, Hirushi Kumarapperuma, Zheng J. Chia, Wenhua Zheng, Suowen Xu, Narin Osman, Peter J. Little
Summary: This study aimed to investigate the role of proximal G proteins in PAR-1 transactivation-dependent signaling. The findings showed that G alpha q is involved in PAR-1-mediated proteoglycan modification, while G alpha 11 has no effect. These findings are significant for the study of other GPCRs involved in vascular pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Cell Biology
Yan Zou, Le Pan, Yi Shen, Xiang Wang, Chenxing Huang, Hao Wang, Xuejuan Jin, Chao Yin, Ying Wang, Jianguo Jia, Juying Qian, Yunzeng Zou, Hui Gong, Junbo Ge
Summary: Progressive cardiac fibrosis is accelerated by elevated serum levels of Wnt5a and Wnt11 in hypertension patients, leading to diastolic dysfunction. Pressure overload increases the secretion of Wnt5a and Wnt11 from cardiomyocytes and cardiac fibroblasts, promoting cardiac fibrosis through the activation of FZD5 and EGFR crosstalk.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Joanne L. Peterson, Brian P. Ceresa
Summary: Maintaining proper structure and function of the cornea is essential for clear vision. The epidermal growth factor receptor (EGFR) plays a crucial role in maintaining and restoring the corneal epithelium. Recent advances in understanding EGFR signaling and trafficking offer new strategies to overcome receptor desensitization and optimize receptor signaling for corneal health.
Article
Gastroenterology & Hepatology
Juhoon So, Minwook Kim, Seung-Hoon Lee, Sungjin Ko, Daniel A. Lee, Hyewon Park, Mizuki Azuma, Michael J. Parsons, David Prober, Donghun Shin
Summary: The differentiation of liver progenitor cells (LPCs) into hepatocytes is crucial for reducing inflammation and fibrosis in chronic liver diseases. Inhibition of the epidermal growth factor receptor (EGFR) signaling pathway promotes LPC-to-hepatocyte differentiation and may serve as a proregenerative therapeutic approach for patients with advanced liver disease. This study provides insights into the mechanisms underlying LPC-mediated liver regeneration and suggests the potential of EGFR inhibitors as a treatment option.
Article
Biochemistry & Molecular Biology
Rizwana Afroz, Hirushi Kumarapperuma, Quang V. N. Nguyen, Raafat Mohamed, Peter J. Little, Danielle Kamato
Summary: This study investigates the dependency of TGFBR1-mediated Smad2 carboxy terminal phosphorylation on the activation of TGFBR1 via TLR4. The results show that LPS-mediated Smad2 phosphorylation is inhibited by the presence of GM6001 inhibitor, but not affected by Y27632 and DPI inhibitors. Additionally, LPS stimulates the expression of PAI-1 mRNA through the activation of TGFBR1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Xiang Tao, Can Chen, Yingxiang Chen, Luoying Zhang, Jiong Hu, Hongjun Yu, Minglu Liang, Qin Fu, Kai Huang
Summary: This study reveals that beta(2)-adrenergic receptor (beta(2)AR) plays a critical role in liver regeneration by interacting with c-met and activating ERK signaling, leading to increased hepatocyte proliferation.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Ikbal Esen Aydingoz, Gulsen Tukenmez Demirci, Deniz Agirbasli, Devrim Oz-Arslan, Guven Yenmis
Summary: The study revealed a significant increase in the amount of EGF in acne patients, indicating a potential role of EGF in the pathogenesis of acne.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Oncology
Daichi Fujimoto, Hiroaki Akamatsu, Takeshi Morimoto, Kazushige Wakuda, Yuki Sato, Yoshitaka Kawa, Toshihide Yokoyama, Motohiro Tamiya, Ryota Hiraoka, Naoki Shingu, Hideki Ikeda, Akihiro Tamiya, Masaki Kanazu, Eisaku Miyauchi, Satoru Miura, Masaaki Yanai, Makiko Yomota, Ryotaro Morinaga, Takashi Yokoi, Akito Hata, Hidekazu Suzuki, Hirotaka Matsumoto, Shinya Sakata, Naoki Furuya, Yuhei Harutani, Ichiro Nakachi, Ayumu Otsuki, Shinya Uematsu, Satoshi Hara, Keiki Yokoo, Takeya Sugimoto, Nobuyuki Yamamoto
Summary: This study aimed to determine the incidence and clinical course of histologic transformation (HT) in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The study found that approximately 3% of EGFR-mutated patients developed HT after acquiring resistance to EGFR-tyrosine kinase inhibitors (TKIs). There was no significant difference in survival between patients with transformation to high-grade neuroendocrine carcinoma and those with transformation to another subtype of non-small cell lung cancer. Cytotoxic agents were likely to be effective in patients with HT, while the effectiveness of immune checkpoint inhibitors was limited.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Claudio Vinegoni, J. Matthew Dubach, Greg M. Thurber, Miles A. Miller, Ralph Mazitschek, Ralph Weissleder
DRUG DISCOVERY TODAY
(2015)
Article
Biochemical Research Methods
Ee Xien Ng, Miles A. Miller, Tengyang Jing, Doug A. Lauffenburger, Chia-Hung Chen
Article
Cell Biology
Miles A. Miller, Suresh Gadde, Christina Pfirschke, Camilla Engblom, Melissa M. Sprachman, Rainer H. Kohler, Katherine S. Yang, Ashley M. Laughney, Gregory Wojtkiewicz, Nazila Kamaly, Sushma Bhonagiri, Mikael J. Pittet, Omid C. Farokhzad, Ralph Weissleder
SCIENCE TRANSLATIONAL MEDICINE
(2015)
Article
Multidisciplinary Sciences
Uwe Schlomann, Garrit Koller, Catharina Conrad, Taheera Ferdous, Panagiota Golfi, Adolfo Molejon Garcia, Sabrina Hofling, Maddy Parsons, Patricia Costa, Robin Soper, Maud Bossard, Thorsten Hagemann, Rozita Roshani, Norbert Sewald, Randal R. Ketchem, Marcia L. Moss, Fred H. Rasmussen, Miles A. Miller, Douglas A. Lauffenburger, David A. Tuveson, Christopher Nimsky, Jorg W. Bartsch
NATURE COMMUNICATIONS
(2015)
Article
Multidisciplinary Sciences
Miles A. Miller, Marcia L. Moss, Gary Powell, Robert Petrovich, Lori Edwards, Aaron S. Meyer, Linda G. Griffith, Douglas A. Lauffenburger
SCIENTIFIC REPORTS
(2015)
Article
Biochemical Research Methods
Marcia L. Moss, Miles A. Miller, Nikola Vujanovic, Toshie Yoneyama, Fred H. Rasmussen
ANALYTICAL BIOCHEMISTRY
(2016)
Article
Biophysics
Ee Xien Ng, Miles A. Miller, Tengyang Jing, Chia-Hung Chen
BIOSENSORS & BIOELECTRONICS
(2016)
Article
Oncology
Miles A. Miller, Ryan J. Sullivan, Douglas A. Lauffenburger
CLINICAL CANCER RESEARCH
(2017)
Article
Cell Biology
Madeleine J. Oudin, Miles A. Miller, Joelle A. Z. Klazen, Tatsiana Kosciuk, Alisha Lussiez, Shannon K. Hughes, Jenny Tadros, James E. Bear, Douglas A. Lauffenburger, Frank B. Gertler
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Oncology
Madeleine J. Oudin, Lucie Barbier, Claudia Schafer, Tatsiana Kosciuk, Miles A. Miller, Sangyoon Han, Oliver Jonas, Douglas A. Lauffenburger, Frank B. Gertler
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Oncology
Miles A. Miller, Madeleine J. Oudin, Ryan J. Sullivan, Stephanie J. Wang, Aaron S. Meyer, Hyungsoon Im, Dennie T. Frederick, Jenny Tadros, Linda G. Griffith, Hakho Lee, Ralph Weissleder, Keith T. Flaherty, Frank B. Gertler, Douglas A. Lauffenburger
Meeting Abstract
Oncology
Miles A. Miller, Mikael Pittet, Ralph Weissleder
CANCER IMMUNOLOGY RESEARCH
(2016)
Article
Multidisciplinary Sciences
Michael F. Cuccarese, J. Matthew Dubach, Christina Pfirschke, Camilla Engblom, Christopher Garris, Miles A. Miller, Mikael J. Pittet, Ralph Weissleder
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Anna Turetsky, Eunha Kim, Rainer H. Kohler, Miles A. Miller, Ralph Weissleder
SCIENTIFIC REPORTS
(2014)
Review
Pharmacology & Pharmacy
Miles A. Miller, Ralph Weissleder
ADVANCED DRUG DELIVERY REVIEWS
(2017)