Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

Safety and Tolerability of Atopaxar in the Treatment of Patients With Acute Coronary Syndromes

(2011) Michelle L. O'Donoghue et al.   CIRCULATION

G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis

(2011) Georgina G.J. Hazell et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example

(2011) Peter J. Little et al.   TheScientificWorldJOURNAL

Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow?

(2011) Nigel J. Pyne et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Signal transduction by protease-activated receptors

(2010) Unice JK Soh et al.   BRITISH JOURNAL OF PHARMACOLOGY

TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2

(2010) Micah L. Burch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor

(2010) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelin-1 Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle is Mediated by Endothelin Receptor Transactivation of the Transforming Growth Factor-β Type I Receptor

(2010) Peter J Little et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

(2010) Michael P. Bokoch et al.   NATURE

Lysophosphatidic Acid Induces αvβ6 Integrin-Mediated TGF-β Activation via the LPA2 Receptor and the Small G Protein Gαq

(2009) Ming Yan Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

G protein-coupled receptors: the inside story

(2009) Kees Jalink et al.   BIOESSAYS

IGF-1 receptor transactivation mediates Src-dependent cortactin phosphorylation in response to angiotensin IIThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.

(2009) Peter Zahradka et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The rapid activation of N-Ras by α-thrombin in fibroblasts is mediated by the specific G-protein Gαi2–Gβ1–Gγ5 and occurs in lipid rafts

(2009) Nathan H. Lents et al.   CELLULAR SIGNALLING

TGF  family signaling: novel insights in development and disease

(2009) K. Wharton et al.   DEVELOPMENT

Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells

(2009) Yinglin Liu et al.   FASEB JOURNAL

Pharmacology of emerging novel platelet inhibitors

(2008) Dominick J. Angiolillo et al.   AMERICAN HEART JOURNAL

Effect of Angiotensin Receptor Blockers on Cardiovascular Events in Patients Undergoing Hemodialysis: An Open-Label Randomized Controlled Trial

(2008) Hiromichi Suzuki et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

(2008) Irwin M Liu et al.   EMBO JOURNAL

Smad and p38 MAP Kinase-mediated Signaling of Proteoglycan Synthesis in Vascular Smooth Muscle

(2008) Harsha Dadlani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways

(2008) Melanie E. Ivey et al.   THROMBOSIS RESEARCH